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doc14404 AcetoUpdate3.pdf

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Page 1

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            "text": "Principal Investigator of Horticulture/ Kentucky State University\nA djunct A assistant Professor of Horticulture/ Univ. of Kentucky"
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Page 5

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            "text": "Inhibitor of complex I of the mitochondrial respiratory chain. Present in young paw paw twig and other tissues\nBullaticin"
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            "text": "Present in young paw paw twig and other tissues"
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            "text": "A simicin",
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Page 8

26 item(s) JSON
caption (1) footer (1) footnote (1) formula (6) heading (1) table (1) table_cell (15)
Page 8
1 · HEADING
2 · CAPTION
3 · TABLE
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19 · FORMULA
20 · FORMULA
21 · FORMULA
22 · FORMULA
23 · FORMULA
24 · FORMULA
25 · FOOTNOTE
26 · FOOTER
Page 8 JSON
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                    "text": "1.59 × 10⁻³",
                    "attrs": {
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                        "rowspan": 1,
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                {
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                        "col": 2,
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                    "text": "1.76 × 10⁻²",
                    "attrs": {
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            "order": 19,
            "type": "formula",
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                "l": 21.84,
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            "text": "\\mathrm{Adriamycin} \\textcircled{R}=\\mathrm{standard~anticarcinoma~drug}",
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                "latex": "\\mathrm{Adriamycin} \\textcircled{R}=\\mathrm{standard~anticarcinoma~drug}",
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            "type": "formula",
            "bbox": {
                "l": 22.32,
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            "text": "\\mathrm{ED}_{50}=\\mathrm{effective~dose~resulting~in~50\\%~cell~death}",
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                "block_label": "display_formula",
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            "text": "A-549 = human hung carcinorma",
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            "order": 24,
            "type": "formula",
            "bbox": {
                "l": 21.12,
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            "text": "\\mathrm{LC}_{50}=\\mathrm{lethal~concentration~resulting~in~}50\\%\\mathrm{~deaths}",
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            "text": "BST = brine shrimp lethality test",
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        {
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            "text": "Bullatacin inhibits mammalian solid tumor cells at concentrations often a billion times lower than A driamycin., as shown in Table 1 (Zhao, et al. 1994b).",
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Page 9

7 item(s) JSON
heading (1) text (6)
Page 9
1 · HEADING
2 · TEXT
3 · TEXT
4 · TEXT
5 · TEXT
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                "r": 682.08,
                "b": 224.16
            },
            "text": "Caparros-L efebvre and Elbaz (1999) reported in Guadeloupe, atypical parkinsonism was abnormally frequent, and represented 75% of progressive parkinsonism while Parkinson's disease accounted for only 25% of the cases."
        },
        {
            "id": "p12.3",
            "order": 3,
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                "l": 77.52,
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            "text": "inversed percentage in comparison with patients living in Europe and North America."
        },
        {
            "id": "p12.4",
            "order": 4,
            "type": "text",
            "bbox": {
                "l": 34.32,
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                "r": 711.6,
                "b": 15.36
            },
            "text": "A higher proportion of patients with atypical parkinsonism (consumed soursop fruit 97%; consumed herbal tea 83%) than patients with Parkinson's disease (fruit 59%; herbal tea 18%) or control with no Parkinson symptoms (fruit 60%; herbal tea 43%)."
        }
    ],
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Page 13

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            "text": "Consumption of an A cetogen Compound-A nonacin",
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            "type": "text",
            "bbox": {
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                "r": 692.64,
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            "text": "Champy et al. (2005) determined the concentrations of annonacin, the major acetogenin in soursop."
        },
        {
            "id": "p13.3",
            "order": 3,
            "type": "text",
            "bbox": {
                "l": 113.52,
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                "r": 659.76,
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            "text": "An average fruit contains about 15 mg of annonacin."
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            "text": "When directly injecting rats for one month with the estimated amounts of annonacin ingested in a year by eating one fruit daily, this induced neurodegeneration in the basal ganglia and mesencephalon (Champy et al., 2004)."
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            "bbox": {
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            "text": "Purified extract and bioavailability upon digestion not examined."
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Page 14

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            "text": "Consumption of Annona fruit and tea-A Link to Parkinsonism?",
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            "text": "The prevalence of Parkinson's disease is roughly 150 per 100,000 inhabitants in the United States or Europe (Schrag et al., 1999)."
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            "text": "Caparros-L efebvre et al. (2005) calculated that the number of PD cases in Guadeloupe would be approximately 640 (out of 420,000 people)"
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            "text": "Y ounger people who had symptoms and stopped\nconsuming Annona products reversed their symptoms"
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Page 15

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            "text": "A typical Parkinsonism in Guadeloupe",
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            "text": "Sensitivity to acetogenin compounds may be limited to those with a specific genetic predisposition in Guadeloupe"
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            "text": "The H2 allele has been reported to carry variants that are protective PSP and is rare (5% vs. 20%) in the Guadeloupian population"
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            "text": "may contribute, in association with unidentified genetic or environmental risk factors, to disease susceptibility (Camuzat et al., 2008)."
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Page 16

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            "text": "Ratnayake, S., J.K. Rupprecht, W.M. Potter, and J.L. M cL aughlin. 1993.",
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Page 17

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            "text": "To determine if extracts of ripe pawpaw fruit pulp display acetogenin activity."
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            "text": "Artemia saline or Sea M onkeys"
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            "text": "A bout nine grams of paw paw pulp was extracted with ethanol and concentrated through a series of methanol and chloroform extractions as described by Ratnayake et al., (1993)."
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Page 23

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            "text": "K entucky State University asked the U.S. Food and Drug Administration (FDA) for an opinion on this topic, and their conclusion was that pawpaw has a long history of food use and the FDA does not currently have any evidence that pawpaw is unsafe to eat."
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Page 24

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Page 25

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1 · TEXT
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