studies will be taking place outside of acute Trusts, which is expected to increase demand for OUH to provide services to these studies.

Table 4. Summary of activity in 2025-26

Participants recruitedStudies open to recruitmentNew studies approved to recruit
Commercial856 (6%)209 (22%)110 (35%)
Non-Commercial12683 (94%)753 (78%)203 (65%)
Interventional5133 (38%)434 (45%)172 (55%)
Non-interventional8406 (62%)528 (55%)141 (45%)
NIHR portfolio10103 (75%)751 (78%)254 (81%)
Non-portfolio3436 (25%)211 (22%)59 (19%)
Totals13539962313

4. Clinical Research Performance

Background

4.1. The government's target was to reduce to less than 150 days the time it takes to set up a clinical trial, by March 2026. The 150-day target applies to all clinical trials, with a focus on commercial interventional clinical trials, at study level. It comprises three stages:

  • Medicines & Healthcare products Regulatory Agency and Research Ethics Committee combined review decision - target is 60 days.
  • Combined review decision to study opening - target is 60 days.
  • Study opening to first participant recruited - target is 30 days.

4.2. In April 2026 the DHSC announced that average set-up time for commercial clinical trials in the UK reduced to 122 days, down from 169 the previous year, surpassing the 150-day target, which is now regarded as a milestone rather than an endpoint, at a study level. This has been attributed to a combination of reduced bureaucracy, standardised processes and investment (~£137m) in research infrastructure, with 99% of studies now receiving regulatory approvals within the 60-day target.

4.3. There is an accompanying expectation that all participating trial sites (like OUH) must complete their set-up activities within 90 days, comprising two stages:

  • Regulatory approval (Health Research Authority) or Date Site Selected, whichever comes later, to site confirmed (i.e. contract signed) - target is 60 days. During this time the Site has to confirm feasibility (clinically and operationally); agree the budget (NCVR);