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SiteRisk
All sites\\dagger1 in 2
Prostate1 in 6
Lung and bronchus1 in 13
Colon and rectum1 in 19
Urinary bladder\\ddagger1 in 26
Melanoma\\S1 in 37
Non-Hodgkin lymphoma1 in 43
Kidney1 in 53
Leukemia1 in 66
Oral Cavity1 in 71
Stomach1 in 91
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SiteRisk
All sites\\dagger1 in 3
Breast1 in 8
Lung & bronchus1 in 16
Colon & rectum1 in 20
Uterine corpus1 in 39
Non-Hodgkin lymphoma1 in 52
Urinary bladder\\ddagger1 in 87
Melanoma\\S1 in 55
Ovary1 in 72
Pancreas1 in 71
Uterine cervix1 in 147
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147", "html_text": "1 in 147", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" } ], "n_rows": 12, "n_cols": 2, "ref": "#/tables/0", "reading_order": 1 }, { "page": 5, "type": "TEXT", "location": { "l": 109.68, "t": 86.4, "r": 413.76, "b": 74.4 }, "text": "* For those free of cancer at beginning of age interval.", "reading_order": 2 }, { "page": 5, "type": "TEXT", "location": { "l": 109.92, "t": 76.56, "r": 669.36, "b": 63.84 }, "text": "† All Sites exclude basal and squamous cell skin cancers and in situ cancers except urinary bladder.", "reading_order": 3 }, { "page": 5, "type": "TEXT", "location": { "l": 111.12, "t": 63.12, "r": 361.92, "b": 50.88 }, "text": "\\ddagger Includes invasive and in situ cancer cases", "reading_order": 4 }, { "page": 5, "type": "TEXT", "location": { "l": 111.6, "t": 50.64, "r": 270.72, "b": 39.36 }, "text": "§ Statistic for white 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"location": { "l": 385.92, "t": 327.6, "r": 746.88, "b": 294 }, "text": "Professor of pharmacognosy", "reading_order": 3 }, { "page": 6, "type": "TEXT", "location": { "l": 340.08, "t": 284.88, "r": 736.56, "b": 59.04 }, "text": "Extracts of pawpaw were are among the most potent of the 3500 species of higher plants screened for bioactive compounds in his laboratories", "reading_order": 4 } ] }, { "page": 7, "items": [ { "page": 7, "type": "TITLE", "location": { "l": 47.52, "t": 457.68, "r": 694.08, "b": 405.6 }, "text": "Paw paw A cetogenin Compounds", "reading_order": 0, "level": 3 }, { "page": 7, "type": "TEXT", "location": { "l": 29.28, "t": 388.08, "r": 446.64, "b": 350.16 }, "text": "A nnonaceous acetogenins", "reading_order": 1 }, { "page": 7, "type": "TEXT", "location": { "l": 72.48, "t": 341.04, "r": 491.28, "b": 308.16 }, "text": "Long unbranched fatty acid chain", "reading_order": 2 }, { "page": 7, "type": "TEXT", "location": { "l": 72.96, "t": 298.56, "r": 435.36, "b": 235.2 }, "text": "over 50 unique annonaceous acetogenins", "reading_order": 3 }, { "page": 7, "type": "DISPLAY_FORMULA", "location": { "l": 516, "t": 393.36, "r": 755.04, "b": 285.6 }, "text": "", "alt": "Skeletal structure of a bis-tetrahydrofuran annonaceous acetogenin with threo and trans labels, butenolide ring, and hydroxy…", "description_source": "claude-haiku-5-5", "reading_order": 4 }, { "page": 7, "type": "TEXT", "location": { "l": 587.28, "t": 271.44, "r": 680.16, "b": 244.8 }, "text": "A simicin", "reading_order": 5 }, { "page": 7, "type": "TEXT", "location": { "l": 30, "t": 223.2, "r": 530.88, "b": 140.16 }, "text": "Inhibitor of complex I of the mitochondrial respiratory chain. Present in young paw paw twig and other tissues\nBullaticin", "reading_order": 6 }, { "page": 7, "type": "TEXT", "location": { "l": 29.76, "t": 127.44, "r": 511.2, "b": 45.84 }, "text": "Present in young paw paw twig and other tissues", "reading_order": 7 }, { "page": 7, "type": "DISPLAY_FORMULA", "location": { "l": 499.44, "t": 125.04, "r": 755.04, "b": 37.44 }, "text": "", "alt": "Skeletal structure of bullatacin, an annonaceous acetogenin with two trans-tetrahydrofuran rings, hydroxyl groups and a bute…", "description_source": "claude-haiku-5-5", "reading_order": 8 }, { "page": 7, "type": "TEXT", "location": { "l": 581.28, "t": 114.96, "r": 680.88, "b": 88.8 }, "text": "Bullaticin", "reading_order": 9 } ] }, { "page": 8, "items": [ { "page": 8, "type": "TITLE", "location": { "l": 65.52, "t": 472.08, "r": 424.8, "b": 424.32 }, "text": "A nti-tumor A ctivity", "reading_order": 0, "level": 3 }, { "page": 8, "type": "TEXT", "location": { "l": 20.4, "t": 389.76, "r": 739.44, "b": 364.32 }, "text": "Table 1. The bioactivities of bullatacin in the brine shrimp test and human solid tumor cell lines.", "reading_order": 1 }, { "page": 8, "type": "TABLE", "location": { "l": 23.76, "t": 342.72, "r": 698.4, "b": 233.52 }, "text": "
CompoundBST LC50 (μ g/ml)ED50 (μ g/ml)MCF-7 ED50 (μ g/ml)HT-29 ED50 (μ g/ml)
Bullatacin1.59 × 10-31.25 × 10-13>101.0 × 10-12
Adriamycin2.57 × 10-11.04 × 10-41.76 × 10-21.53 × 10-4
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"cell_header_index": 3, "rowspan": 1, "colspan": 1, "column_header": true, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 563.472, 306.32, 698.4, 342.72 ], "text": "HT-29 ED50 (μ g/ml)", "html_text": "HT-29 ED50 (μ g/ml)", "links": [], "cell_header_index": 4, "rowspan": 1, "colspan": 1, "column_header": true, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 1, "location": [ 23.76, 269.92, 698.4, 306.32 ], "cells": [ { "location": [ 23.76, 269.92, 158.688, 306.32 ], "text": "Bullatacin", "html_text": "Bullatacin", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 158.688, 269.92, 293.616, 306.32 ], "text": "1.59 × 10-3", "html_text": "1.59 × 10-3", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 293.616, 269.92, 428.544, 306.32 ], "text": "1.25 × 10-13", "html_text": "1.25 × 10-13", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 428.544, 269.92, 563.472, 306.32 ], "text": ">10", "html_text": ">10", "links": [], "cell_header_index": 3, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 563.472, 269.92, 698.4, 306.32 ], "text": "1.0 × 10-12", "html_text": "1.0 × 10-12", "links": [], "cell_header_index": 4, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 2, "location": [ 23.76, 233.52, 698.4, 269.92 ], "cells": [ { "location": [ 23.76, 233.52, 158.688, 269.92 ], "text": "Adriamycin", "html_text": "Adriamycin", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 158.688, 233.52, 293.616, 269.92 ], "text": "2.57 × 10-1", "html_text": "2.57 × 10-1", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 293.616, 233.52, 428.544, 269.92 ], "text": "1.04 × 10-4", "html_text": "1.04 × 10-4", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 428.544, 233.52, 563.472, 269.92 ], "text": "1.76 × 10-2", "html_text": "1.76 × 10-2", "links": [], "cell_header_index": 3, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 563.472, 233.52, 698.4, 269.92 ], "text": "1.53 × 10-4", "html_text": "1.53 × 10-4", "links": [], "cell_header_index": 4, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" } ], "n_rows": 3, "n_cols": 5, "ref": "#/tables/0", "reading_order": 2 }, { "page": 8, "type": "TEXT", "location": { "l": 22.8, "t": 227.76, "r": 273.12, "b": 204.24 }, "text": "BST = brine shrimp lethality test", "reading_order": 3 }, { "page": 8, "type": "DISPLAY_FORMULA", "location": { "l": 21.84, "t": 200.16, "r": 368.16, "b": 176.16 }, "text": "Adriamycin textcircled R = standard anticarcinoma drug", "latex": "\\mathrm{Adriamycin} \\textcircled{R}=\\mathrm{standard~anticarcinoma~drug}", "reading_order": 4 }, { "page": 8, "type": "DISPLAY_FORMULA", "location": { "l": 22.32, "t": 173.04, "r": 398.88, "b": 145.68 }, "text": "ED 50 = effective dose resulting in 50% cell death", "latex": "\\mathrm{E D}_{50}=\\mathrm{e f f e c t i v e~d o s e~r e s u l t i n g~i n~50\\%~c e l l~d e a t h}", "reading_order": 5 }, { "page": 8, "type": "DISPLAY_FORMULA", "location": { "l": 412.56, "t": 227.28, "r": 662.16, "b": 204.24 }, "text": "A -549 = human hung carcinorma", "latex": "\\mathrm{A}-549=\\mathrm{h u m a n~h u n g~c a r c i n o r m a}", "reading_order": 6 }, { "page": 8, "type": "DISPLAY_FORMULA", "location": { "l": 412.56, "t": 200.4, "r": 686.88, "b": 176.4 }, "text": "MCF -7 = human breast carcinoma", "latex": "\\mathrm{MCF}-7=\\mathrm{h u m a n~b r e a s t~c a r c i n o m a}", "reading_order": 7 }, { "page": 8, "type": "DISPLAY_FORMULA", "location": { "l": 413.04, "t": 169.92, "r": 674.16, "b": 145.2 }, "text": "HT-29 = human colon carcinoma", "latex": "\\mathrm{HT-29}=\\mathrm{human~colon~carcinoma}", "reading_order": 8 }, { "page": 8, "type": "DISPLAY_FORMULA", "location": { "l": 21.12, "t": 139.68, "r": 415.92, "b": 110.4 }, "text": "LC 50 = lethal concentration resulting in 50% deaths", "latex": "\\mathrm{L C}_{50}=\\mathrm{l e t h a l~c o n c e n t r a t i o n~r e s u l t i n g~i n~}50\\%\\mathrm{~d e a t h s}", "reading_order": 9 }, { "page": 8, "type": "TEXT", "location": { "l": 81.12, "t": 57.6, "r": 687.12, "b": 17.04 }, "text": "Bullatacin inhibits mammalian solid tumor cells at concentrations often a billion times lower than A driamycin., as shown in Table 1 (Zhao, et al. 1994b).", "reading_order": 10 } ] }, { "page": 9, "items": [ { "page": 9, "type": "TITLE", "location": { "l": 47.76, "t": 474.96, "r": 691.92, "b": 423.84 }, "text": "Paw paw A cetogenin Compounds", "reading_order": 0, "level": 3 }, { "page": 9, "type": "TEXT", "location": { "l": 30, "t": 408.48, "r": 696.48, "b": 309.6 }, "text": "The powerful cytotoxicity, in vivo antitumor, pesticidal, antimalarial, antiviral, and antimicrobial effects indicated a myriad of potentially useful applications.", "reading_order": 1 }, { "page": 9, "type": "TEXT", "location": { "l": 30.48, "t": 300.48, "r": 590.4, "b": 270 }, "text": "Commercial development of these compounds", "reading_order": 2 }, { "page": 9, "type": "TEXT", "location": { "l": 118.08, "t": 262.08, "r": 688.32, "b": 206.64 }, "text": "shampoo, highly effective in treating infestations of head lice, fleas, and ticks.", "reading_order": 3 }, { "page": 9, "type": "TEXT", "location": { "l": 118.32, "t": 198.72, "r": 653.52, "b": 142.8 }, "text": "pesticidal sprays, which protects host plants against a diversity of pests.", "reading_order": 4 }, { "page": 9, "type": "TEXT", "location": { "l": 118.32, "t": 135.36, "r": 654.48, "b": 80.64 }, "text": "an ointment for treatment of oral herpes (HSV-1) and other skin afflictions.", "reading_order": 5 }, { "page": 9, "type": "TEXT", "location": { "l": 118.32, "t": 72.24, "r": 660.96, "b": 14.88 }, "text": "The extract (in capsule form) has been used by certain cancer patients as a botanical supplement product.", "reading_order": 6 } ] }, { "page": 10, "items": [ { "page": 10, "type": "TITLE", "location": { "l": 98.88, "t": 414.48, "r": 347.04, "b": 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"l": 342.24, "t": 257.76, "r": 471.6, "b": 247.2 }, "text": "·Selectively affects specific cells.", "reading_order": 33 }, { "page": 10, "type": "TEXT", "location": { "l": 342, "t": 247.92, "r": 600.48, "b": 225.12 }, "text": "•Modulates the production of ATP in mitochondria of specific cells.\n•May help modulate the growth of blood vessels near specific cells.", "reading_order": 34 }, { "page": 10, "type": "TEXT", "location": { "l": 341.28, "t": 218.16, "r": 712.56, "b": 184.56 }, "text": "Paw Paw Cell-RegTM [Immune]. Because health begins in the body's cells, it is important to support the health of all cells. Paw Paw Cell-Reg is a unique product that selectively targets specific cells to enhance the overall health of the body.", "reading_order": 35 }, { "page": 10, "type": "TEXT", "location": { "l": 341.28, "t": 176.64, "r": 720.96, "b": 124.32 }, "text": "Over 50 active compounds exist in Paw Paw Cell-Reg and these complex chemicals are called acetogenins. Acetogenins affect the production of ATP in the mitochondria (the powerhouse) of the cell. ATP is the major source of cellular energy. By selectively modulating the production of ATP in specific cells, the acetogenins affect the viability of specific cells and the growth of blood vessels that nourish them.", "reading_order": 36 }, { "page": 10, "type": "TEXT", "location": { "l": 341.52, "t": 116.88, "r": 704.4, "b": 90.96 }, "text": "A clinical study with over 100 participants showed that the paw paw extract, containing a Read more...", "reading_order": 37 } ] }, { "page": 11, "items": [ { "page": 11, "type": "FIGURE", "location": { "l": 582, "t": 475.44, "r": 732.48, "b": 374.88 }, "text": "", "reading_order": 0 }, { "page": 11, "type": "TITLE", "location": { "l": 23.52, "t": 465.6, "r": 568.8, "b": 420.72 }, "text": "Botany and Genetic Resources", "reading_order": 1, "level": 3 }, { "page": 11, "type": "TITLE", "location": { "l": 4.56, "t": 377.76, "r": 538.56, "b": 266.64 }, "text": "Asimina triloba is a member of the tropical Custard Apple or Annonaceae family.", "reading_order": 2, "level": 2 }, { "page": 11, "type": "FIGURE", "location": { "l": 551.76, "t": 307.2, "r": 755.04, "b": 177.6 }, "text": "", "reading_order": 3 }, { "page": 11, "type": "TEXT", "location": { "l": 49.44, "t": 257.76, "r": 438.72, "b": 230.64 }, "text": "custard apple (Annona reticulata L.)", "reading_order": 4 }, { "page": 11, "type": "TEXT", "location": { "l": 49.92, "t": 223.68, "r": 392.88, "b": 196.32 }, "text": "cherimoya (A. cherimola Mill.)", "reading_order": 5 }, { "page": 11, "type": "TEXT", "location": { "l": 50.16, "t": 187.92, "r": 490.08, "b": 161.28 }, "text": "sweetsop or sugar apple (A. squamosa L.)", "reading_order": 6 }, { "page": 11, "type": "FIGURE", "location": { "l": 582.48, "t": 173.76, "r": 755.76, "b": 0.48 }, "text": "", "reading_order": 7 }, { "page": 11, "type": "TEXT", "location": { "l": 50.64, "t": 154.08, "r": 465.6, "b": 126.96 }, "text": "atemoya (A. squamosa x A. cherimola)", "reading_order": 8 }, { "page": 11, "type": "TEXT", "location": { "l": 50.88, "t": 119.76, "r": 326.16, "b": 92.16 }, "text": "soursop (A. muricata L.)", "reading_order": 9 } ] }, { "page": 12, "items": [ { "page": 12, "type": "TITLE", "location": { "l": 60, "t": 481.44, "r": 680.16, "b": 390.48 }, "text": "Consumption of Annona fruit and tea-\nA Link to Parkinsonism?", "reading_order": 0, "level": 3 }, { "page": 12, "type": "TEXT", "location": { "l": 34.8, "t": 376.08, "r": 682.08, "b": 224.16 }, "text": "Caparros-L efebvre and Elbaz (1999) reported in Guadeloupe, atypical parkinsonism was abnormally frequent, and represented 75% of progressive parkinsonism while Parkinson's disease accounted for only 25% of the cases.", "reading_order": 1 }, { "page": 12, "type": "TEXT", "location": { "l": 77.52, "t": 220.56, "r": 674.4, "b": 176.16 }, "text": "inversed percentage in comparison with patients living in Europe and North America.", "reading_order": 2 }, { "page": 12, "type": "TEXT", "location": { "l": 34.32, "t": 170.16, "r": 711.6, "b": 15.36 }, "text": "A higher proportion of patients with atypical parkinsonism (consumed soursop fruit 97%; consumed herbal tea 83%) than patients with Parkinson's disease (fruit 59%; herbal tea 18%) or control with no Parkinson symptoms (fruit 60%; herbal tea 43%).", "reading_order": 3 } ] }, { "page": 13, "items": [ { "page": 13, "type": "TITLE", "location": { "l": 66.24, "t": 489.36, "r": 589.92, "b": 390 }, "text": "Consumption of an A cetogen Compound-A nonacin", "reading_order": 0, "level": 2 }, { "page": 13, "type": "TEXT", "location": { "l": 69.36, "t": 365.04, "r": 692.64, "b": 303.6 }, "text": "Champy et al. (2005) determined the concentrations of annonacin, the major acetogenin in soursop.", "reading_order": 1 }, { "page": 13, "type": "TEXT", "location": { "l": 113.52, "t": 299.04, "r": 659.76, "b": 271.68 }, "text": "An average fruit contains about 15 mg of annonacin.", "reading_order": 2 }, { "page": 13, "type": "TEXT", "location": { "l": 69.84, "t": 266.16, "r": 710.64, "b": 114.96 }, "text": "When directly injecting rats for one month with the estimated amounts of annonacin ingested in a year by eating one fruit daily, this induced neurodegeneration in the basal ganglia and mesencephalon (Champy et al., 2004).", "reading_order": 3 }, { "page": 13, "type": "TEXT", "location": { "l": 69.6, "t": 108.24, "r": 716.16, "b": 48 }, "text": "Purified extract and bioavailability upon digestion not examined.", "reading_order": 4 } ] }, { "page": 14, "items": [ { "page": 14, "type": "TITLE", "location": { "l": 60.24, "t": 490.08, "r": 666, "b": 391.44 }, "text": "Consumption of Annona fruit and tea-A Link to Parkinsonism?", "reading_order": 0, "level": 2 }, { "page": 14, "type": "TEXT", "location": { "l": 34.56, "t": 378.24, "r": 727.92, "b": 265.2 }, "text": "The prevalence of Parkinson's disease is roughly 150 per 100,000 inhabitants in the United States or Europe (Schrag et al., 1999).", "reading_order": 1 }, { "page": 14, "type": "TEXT", "location": { "l": 34.32, "t": 255.6, "r": 723.36, "b": 140.64 }, "text": "Caparros-L efebvre et al. (2005) calculated that the number of PD cases in Guadeloupe would be approximately 640 (out of 420,000 people)", "reading_order": 2 }, { "page": 14, "type": "TEXT", "location": { "l": 80.16, "t": 134.64, "r": 304.56, "b": 101.52 }, "text": "152 per 100,000", "reading_order": 3 }, { "page": 14, "type": "TEXT", "location": { "l": 80.16, "t": 93.6, "r": 723.6, "b": 26.16 }, "text": "Y ounger people who had symptoms and stopped\nconsuming Annona products reversed their symptoms", "reading_order": 4 } ] }, { "page": 15, "items": [ { "page": 15, "type": "TITLE", "location": { "l": 44.4, "t": 465.84, "r": 724.8, "b": 417.6 }, "text": "A typical Parkinsonism in Guadeloupe", "reading_order": 0, "level": 3 }, { "page": 15, "type": "TEXT", "location": { "l": 29.52, "t": 396.24, "r": 646.32, "b": 282 }, "text": "Sensitivity to acetogenin compounds may be limited to those with a specific genetic predisposition in Guadeloupe", "reading_order": 1 }, { "page": 15, "type": "TEXT", "location": { "l": 29.52, "t": 273.12, "r": 694.32, "b": 160.8 }, "text": "The H2 allele has been reported to carry variants that are protective PSP and is rare (5% vs. 20%) in the Guadeloupian population", "reading_order": 2 }, { "page": 15, "type": "TEXT", "location": { "l": 72.96, "t": 151.44, "r": 650.64, "b": 51.84 }, "text": "may contribute, in association with unidentified genetic or environmental risk factors, to disease susceptibility (Camuzat et al., 2008).", "reading_order": 3 } ] }, { "page": 16, "items": [ { "page": 16, "type": "TEXT", "location": { "l": 12.96, "t": 487.2, "r": 738.72, "b": 445.2 }, "text": "Table 1. Brine shrimp lethality and percentage yields of F005 (90% aqueous methanol fraction) from various plant parts of Asimina triloba.", "reading_order": 0 }, { "page": 16, "type": "TABLE", "location": { "l": 140.64, "t": 402.96, "r": 637.68, "b": 38.4 }, "text": "
Plant part extractedLC50 (ppm)2Yield of F005 (%)
Twigsy0.042 (0.02-0.09)1.78
Unripe fruitx0.060 (0.03-0.08)5.11
Root woodw0.060 (0.03-0.08)1.27
Seedv0.065 (0.03-0.10)4.03
Stem barkx,u0.077 (0.04-0.12)2.71
Stem barky,u0.102 (0.06-0.15)1.96
Stem barky0.104 (0.03-0.20)2.52
Root barkw0.135 (0.09-0.21)2.72
Whole stem: wood, bark and leavesy0.202 (0.14-0.31)1.60
Stem woody4.86 (0.37-11.93)0.90
Leavesy53.6 (33-82)4.36
", "rows": [ { "row_index": 0, "location": [ 140.64, 372.58, 637.68, 402.96 ], "cells": [ { "location": [ 140.64, 372.58, 306.32, 402.96 ], "text": "Plant part extracted", "html_text": "Plant part extracted", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": true, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 306.32, 372.58, 472, 402.96 ], "text": "LC50 (ppm)2", "html_text": "LC50 (ppm)2", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": true, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 472, 372.58, 637.68, 402.96 ], "text": "Yield of F005 (%)", "html_text": "Yield of F005 (%)", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": true, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 1, "location": [ 140.64, 342.2, 637.68, 372.58 ], "cells": [ { "location": [ 140.64, 342.2, 306.32, 372.58 ], "text": "Twigsy", "html_text": "Twigsy", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": true, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 306.32, 342.2, 472, 372.58 ], "text": "0.042 (0.02-0.09)", "html_text": "0.042 (0.02-0.09)", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 472, 342.2, 637.68, 372.58 ], "text": "1.78", "html_text": "1.78", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 2, "location": [ 140.64, 311.82, 637.68, 342.2 ], "cells": [ { "location": [ 140.64, 311.82, 306.32, 342.2 ], "text": "Unripe fruitx", "html_text": "Unripe fruitx", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": true, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 306.32, 311.82, 472, 342.2 ], "text": "0.060 (0.03-0.08)", "html_text": "0.060 (0.03-0.08)", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 472, 311.82, 637.68, 342.2 ], "text": "5.11", "html_text": "5.11", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 3, "location": [ 140.64, 281.44, 637.68, 311.82 ], "cells": [ { "location": [ 140.64, 281.44, 306.32, 311.82 ], "text": "Root woodw", "html_text": "Root woodw", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": true, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 306.32, 281.44, 472, 311.82 ], "text": "0.060 (0.03-0.08)", "html_text": "0.060 (0.03-0.08)", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 472, 281.44, 637.68, 311.82 ], "text": "1.27", "html_text": "1.27", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 4, "location": [ 140.64, 251.06, 637.68, 281.44 ], "cells": [ { "location": [ 140.64, 251.06, 306.32, 281.44 ], "text": "Seedv", "html_text": "Seedv", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": true, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 306.32, 251.06, 472, 281.44 ], "text": "0.065 (0.03-0.10)", "html_text": "0.065 (0.03-0.10)", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 472, 251.06, 637.68, 281.44 ], "text": "4.03", "html_text": "4.03", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 5, "location": [ 140.64, 220.68, 637.68, 251.06 ], "cells": [ { "location": [ 140.64, 220.68, 306.32, 251.06 ], "text": "Stem barkx,u", "html_text": "Stem barkx,u", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": true, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 306.32, 220.68, 472, 251.06 ], "text": "0.077 (0.04-0.12)", "html_text": "0.077 (0.04-0.12)", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 472, 220.68, 637.68, 251.06 ], "text": "2.71", "html_text": "2.71", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 6, "location": [ 140.64, 190.3, 637.68, 220.68 ], "cells": [ { "location": [ 140.64, 190.3, 306.32, 220.68 ], "text": "Stem barky,u", "html_text": "Stem barky,u", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": true, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 306.32, 190.3, 472, 220.68 ], "text": "0.102 (0.06-0.15)", "html_text": "0.102 (0.06-0.15)", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 472, 190.3, 637.68, 220.68 ], "text": "1.96", "html_text": "1.96", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 7, "location": [ 140.64, 159.92, 637.68, 190.3 ], "cells": [ { "location": [ 140.64, 159.92, 306.32, 190.3 ], "text": "Stem barky", "html_text": "Stem barky", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": true, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 306.32, 159.92, 472, 190.3 ], "text": "0.104 (0.03-0.20)", "html_text": "0.104 (0.03-0.20)", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 472, 159.92, 637.68, 190.3 ], "text": "2.52", "html_text": "2.52", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 8, "location": [ 140.64, 129.54, 637.68, 159.92 ], "cells": [ { "location": [ 140.64, 129.54, 306.32, 159.92 ], "text": "Root barkw", "html_text": "Root barkw", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": true, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 306.32, 129.54, 472, 159.92 ], "text": "0.135 (0.09-0.21)", "html_text": "0.135 (0.09-0.21)", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 472, 129.54, 637.68, 159.92 ], "text": "2.72", "html_text": "2.72", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 9, "location": [ 140.64, 99.16, 637.68, 129.54 ], "cells": [ { "location": [ 140.64, 99.16, 306.32, 129.54 ], "text": "Whole stem: wood, bark and leavesy", "html_text": "Whole stem: wood, bark and leavesy", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": true, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 306.32, 99.16, 472, 129.54 ], "text": "0.202 (0.14-0.31)", "html_text": "0.202 (0.14-0.31)", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 472, 99.16, 637.68, 129.54 ], "text": "1.60", "html_text": "1.60", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 10, "location": [ 140.64, 68.78, 637.68, 99.16 ], "cells": [ { "location": [ 140.64, 68.78, 306.32, 99.16 ], "text": "Stem woody", "html_text": "Stem woody", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": true, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 306.32, 68.78, 472, 99.16 ], "text": "4.86 (0.37-11.93)", "html_text": "4.86 (0.37-11.93)", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 472, 68.78, 637.68, 99.16 ], "text": "0.90", "html_text": "0.90", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 11, "location": [ 140.64, 38.4, 637.68, 68.78 ], "cells": [ { "location": [ 140.64, 38.4, 306.32, 68.78 ], "text": "Leavesy", "html_text": "Leavesy", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": true, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 306.32, 38.4, 472, 68.78 ], "text": "53.6 (33-82)", "html_text": "53.6 (33-82)", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 472, 38.4, 637.68, 68.78 ], "text": "4.36", "html_text": "4.36", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" } ], "n_rows": 12, "n_cols": 3, "ref": "#/tables/0", "reading_order": 1 }, { "page": 16, "type": "TEXT", "location": { "l": 273.84, "t": 24.24, "r": 743.28, "b": 1.92 }, "text": "Ratnayake, S., J.K. Rupprecht, W.M. Potter, and J.L. M cL aughlin. 1993.", "reading_order": 2 } ] }, { "page": 17, "items": [ { "page": 17, "type": "TITLE", "location": { "l": 66.48, "t": 437.52, "r": 245.28, "b": 389.04 }, "text": "Objective", "reading_order": 0, "level": 3 }, { "page": 17, "type": "TEXT", "location": { "l": 97.44, "t": 362.16, "r": 682.8, "b": 282.96 }, "text": "To determine if extracts of ripe pawpaw fruit pulp display acetogenin activity.", "reading_order": 1 } ] }, { "page": 18, "items": [ { "page": 18, "type": "TITLE", "location": { "l": 63.6, "t": 454.56, "r": 714.72, "b": 405.12 }, "text": "Brine Shrimp Lethality Assay (BST)", "reading_order": 0, "level": 3 }, { "page": 18, "type": "TEXT", "location": { "l": 46.08, "t": 384, "r": 492.96, "b": 348.24 }, "text": "Artemia saline or Sea M onkeys", "reading_order": 1 }, { "page": 18, "type": "TEXT", "location": { "l": 46.8, "t": 337.92, "r": 695.04, "b": 262.32 }, "text": "Rapid, in house, and low cost substitute for cytotoxic assays developed by Dr. M cL aughlin", "reading_order": 2 }, { "page": 18, "type": "TEXT", "location": { "l": 45.84, "t": 253.2, "r": 633.6, "b": 140.64 }, "text": "Responsible for the isolation of numerous, chemical and pharmacologically diverse antitumor and pesticidal compounds.", "reading_order": 3 }, { "page": 18, "type": "TEXT", "location": { "l": 44.88, "t": 130.56, "r": 683.52, "b": 16.8 }, "text": "Records the lethal concentration to kill 50% of the shrimp (L C50 value with upper and lower 95% confidence levels)", "reading_order": 4 } ] }, { "page": 19, "items": [ { "page": 19, "type": "TITLE", "location": { "l": 66.72, "t": 432.72, "r": 706.32, "b": 388.8 }, "text": "Brine Shrimp Test-A cetogenin Activity", "reading_order": 0, "level": 3 }, { "page": 19, "type": "TEXT", "location": { "l": 70.32, "t": 368.16, "r": 672, "b": 256.56 }, "text": "A bout nine grams of paw paw pulp was extracted with ethanol and concentrated through a series of methanol and chloroform extractions as described by Ratnayake et al., (1993).", "reading_order": 1 }, { "page": 19, "type": "TEXT", "location": { "l": 70.32, "t": 252.96, "r": 683.28, "b": 143.04 }, "text": "Twenty brine shrimp larvae, taken 48 h after initiation of hatching in artificial sea water were added to each vial (5mL) containing 0, 10, 100 and 1000 ppm concentrations of extract.", "reading_order": 2 }, { "page": 19, "type": "TEXT", "location": { "l": 70.32, "t": 139.44, "r": 676.32, "b": 83.28 }, "text": "A after 24 h, survivors were counted. SD from three extracts.", "reading_order": 3 } ] }, { "page": 20, "items": [ { "page": 20, "type": "FIGURE", "location": { "l": 149.52, "t": 432.48, "r": 624.48, "b": 59.52 }, "text": "", "reading_order": 0 } ] }, { "page": 21, "items": [ { "page": 21, "type": "TEXT", "location": { "l": 31.2, "t": 395.52, "r": 731.52, "b": 306.96 }, "text": "Table 3. Brine Shrimp Mortility (LC50) Values for the Pawpaw Cultivars 'Mitchell', 'NC-1', 'Overleese', 'Zimmerman', 'Wells', and 'Sunflower' from Frozen Pulp of Ripe Fruita", "reading_order": 0 }, { "page": 21, "type": "TABLE", "location": { "l": 30.72, "t": 303.84, "r": 732, "b": 150.96 }, "text": "
pawpaw cultivarLC50 (ppm)pawpaw cultivarLC50 (ppm)
‘Mitchell’0.31 (± 1.02)‘Zimmerman’4.09 (± 0.49)
‘Overleese’0.38 (± 1.48)‘Wells’7.33 (± 1.27)
‘NC-1’0.89 (± 1.41)‘Sunflower’8.60 (± 0.42)
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"rowspan": 1, "colspan": 1, "column_header": true, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 1, "location": [ 30.72, 227.4, 732, 265.62 ], "cells": [ { "location": [ 30.72, 227.4, 206.04, 265.62 ], "text": "‘Mitchell’", "html_text": "‘Mitchell’", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": true, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 206.04, 227.4, 381.36, 265.62 ], "text": "0.31 (± 1.02)", "html_text": "0.31 (± 1.02)", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 381.36, 227.4, 556.68, 265.62 ], "text": "‘Zimmerman’", "html_text": "‘Zimmerman’", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 556.68, 227.4, 732, 265.62 ], "text": "4.09 (± 0.49)", "html_text": "4.09 (± 0.49)", "links": [], "cell_header_index": 3, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 2, "location": [ 30.72, 189.18, 732, 227.4 ], "cells": [ { "location": [ 30.72, 189.18, 206.04, 227.4 ], "text": "‘Overleese’", "html_text": "‘Overleese’", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": true, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 206.04, 189.18, 381.36, 227.4 ], "text": "0.38 (± 1.48)", "html_text": "0.38 (± 1.48)", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 381.36, 189.18, 556.68, 227.4 ], "text": "‘Wells’", "html_text": "‘Wells’", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 556.68, 189.18, 732, 227.4 ], "text": "7.33 (± 1.27)", "html_text": "7.33 (± 1.27)", "links": [], "cell_header_index": 3, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 3, "location": [ 30.72, 150.96, 732, 189.18 ], "cells": [ { "location": [ 30.72, 150.96, 206.04, 189.18 ], "text": "‘NC-1’", "html_text": "‘NC-1’", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": true, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 206.04, 150.96, 381.36, 189.18 ], "text": "0.89 (± 1.41)", "html_text": "0.89 (± 1.41)", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 381.36, 150.96, 556.68, 189.18 ], "text": "‘Sunflower’", "html_text": "‘Sunflower’", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 556.68, 150.96, 732, 189.18 ], "text": "8.60 (± 0.42)", "html_text": "8.60 (± 0.42)", "links": [], "cell_header_index": 3, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" } ], "n_rows": 4, "n_cols": 4, "ref": "#/tables/0", "reading_order": 1 }, { "page": 21, "type": "TEXT", "location": { "l": 57.36, "t": 140.88, "r": 385.92, "b": 112.32 }, "text": "aParentheses enclose standard error.", "reading_order": 2 }, { "page": 21, "type": "TEXT", "location": { "l": 619.44, "t": 23.76, "r": 750, "b": 2.88 }, "text": "Pomper et al., 2009", "reading_order": 3 } ] }, { "page": 22, "items": [ { "page": 22, "type": "TITLE", "location": { "l": 87.6, "t": 491.04, "r": 668.16, "b": 406.56 }, "text": "Confirmation of A cetogenins in ‘NC-1’ Pulp\nSubjected to HPLC S-M ass Spec A analysis", "reading_order": 0, "level": 4 }, { "page": 22, "type": "FIGURE", "location": { "l": 21.6, "t": 402.24, "r": 756, "b": 8.4 }, "text": "", "reading_order": 1 }, { "page": 22, "type": "FIGURE", "location": { "l": 25.44, "t": 398.88, "r": 576.48, "b": 6.72 }, "text": "", "reading_order": 2 }, { "page": 22, "type": "DISPLAY_FORMULA", "location": { "l": 587.04, "t": 402.24, "r": 756, "b": 24.96 }, "text": "", "alt": "Skeletal structure of an annonaceous acetogenin with two bis-tetrahydrofuran rings, threo/trans labels, hydroxyls, and a but…", "description_source": "claude-haiku-5-5", "reading_order": 3 }, { "page": 22, "type": "TEXT", "location": { "l": 619.92, "t": 24.24, "r": 749.04, "b": 2.64 }, "text": "Pomper et al., 2009", "reading_order": 4 } ] }, { "page": 23, "items": [ { "page": 23, "type": "TITLE", "location": { "l": 65.52, "t": 437.52, "r": 435.84, "b": 389.28 }, "text": "W hat the FDA Says:", "reading_order": 0, "level": 3 }, { "page": 23, "type": "TEXT", "location": { "l": 43.68, "t": 366.96, "r": 687.12, "b": 135.6 }, "text": "K entucky State University asked the U.S. Food and Drug Administration (FDA) for an opinion on this topic, and their conclusion was that pawpaw has a long history of food use and the FDA does not currently have any evidence that pawpaw is unsafe to eat.", "reading_order": 1 } ] }, { "page": 24, "items": [ { "page": 24, "type": "TEXT", "location": { "l": 39.84, "t": 431.76, "r": 724.32, "b": 347.04 }, "text": "Table 1. Highest and Lowest Brine Shrimp Test LC50 Values of Extracts from 135 Individual Paw Paw Trees Growing at the WMREC Plantationa,b", "reading_order": 0 }, { "page": 24, "type": "TABLE", "location": { "l": 43.2, "t": 342, "r": 712.56, "b": 149.28 }, "text": "
high producerslow producers
tree sampleBST- LC50 (ppm)tree sampleBST- LC50 (ppm)
4-110.033 \\pm 0.00102-3232 \\pm 12
5-820.053 \\pm 0.0151-1912 \\pm 4.7
4-700.056 \\pm 0.03544-4610 \\pm 0.55
2-880.063 \\pm 0.0205-148.4 \\pm 2.5
", "rows": [ { "row_index": 0, "location": [ 43.2, 309.88, 712.56, 342 ], "cells": [ { "location": [ 43.2, 309.88, 377.88, 342 ], "text": "high producers", "html_text": "high producers", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 2, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 377.88, 309.88, 712.56, 342 ], "text": "low producers", "html_text": "low producers", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 2, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 1, "location": [ 43.2, 277.76, 712.56, 309.88 ], "cells": [ { "location": [ 43.2, 277.76, 210.54, 309.88 ], "text": "tree sample", "html_text": "tree sample", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": true, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 210.54, 277.76, 377.88, 309.88 ], "text": "BST- LC50 (ppm)", "html_text": "BST- LC50 (ppm)", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": true, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 377.88, 277.76, 545.22, 309.88 ], "text": "tree sample", "html_text": "tree sample", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": true, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 545.22, 277.76, 712.56, 309.88 ], "text": "BST- LC50 (ppm)", "html_text": "BST- LC50 (ppm)", "links": [], "cell_header_index": 3, "rowspan": 1, "colspan": 1, "column_header": true, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 2, "location": [ 43.2, 245.64, 712.56, 277.76 ], "cells": [ { "location": [ 43.2, 245.64, 210.54, 277.76 ], "text": "4-11", "html_text": "4-11", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 210.54, 245.64, 377.88, 277.76 ], "text": "0.033 \\pm 0.0010", "html_text": "0.033 \\pm 0.0010", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 377.88, 245.64, 545.22, 277.76 ], "text": "2-32", "html_text": "2-32", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 545.22, 245.64, 712.56, 277.76 ], "text": "32 \\pm 12", "html_text": "32 \\pm 12", "links": [], "cell_header_index": 3, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 3, "location": [ 43.2, 213.52, 712.56, 245.64 ], "cells": [ { "location": [ 43.2, 213.52, 210.54, 245.64 ], "text": "5-82", "html_text": "5-82", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 210.54, 213.52, 377.88, 245.64 ], "text": "0.053 \\pm 0.015", "html_text": "0.053 \\pm 0.015", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 377.88, 213.52, 545.22, 245.64 ], "text": "1-19", "html_text": "1-19", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 545.22, 213.52, 712.56, 245.64 ], "text": "12 \\pm 4.7", "html_text": "12 \\pm 4.7", "links": [], "cell_header_index": 3, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 4, "location": [ 43.2, 181.4, 712.56, 213.52 ], "cells": [ { "location": [ 43.2, 181.4, 210.54, 213.52 ], "text": "4-70", "html_text": "4-70", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 210.54, 181.4, 377.88, 213.52 ], "text": "0.056 \\pm 0.0354", "html_text": "0.056 \\pm 0.0354", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 377.88, 181.4, 545.22, 213.52 ], "text": "4-46", "html_text": "4-46", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 545.22, 181.4, 712.56, 213.52 ], "text": "10 \\pm 0.55", "html_text": "10 \\pm 0.55", "links": [], "cell_header_index": 3, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" }, { "row_index": 5, "location": [ 43.2, 149.28, 712.56, 181.4 ], "cells": [ { "location": [ 43.2, 149.28, 210.54, 181.4 ], "text": "2-88", "html_text": "2-88", "links": [], "cell_header_index": 0, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 210.54, 149.28, 377.88, 181.4 ], "text": "0.063 \\pm 0.020", "html_text": "0.063 \\pm 0.020", "links": [], "cell_header_index": 1, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 377.88, 149.28, 545.22, 181.4 ], "text": "5-14", "html_text": "5-14", "links": [], "cell_header_index": 2, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" }, { "location": [ 545.22, 149.28, 712.56, 181.4 ], "text": "8.4 \\pm 2.5", "html_text": "8.4 \\pm 2.5", "links": [], "cell_header_index": 3, "rowspan": 1, "colspan": 1, "column_header": false, "row_header": false, "placeholder": false, "ref": "#/tables/0" } ], "ref": "#/tables/0" } ], "n_rows": 6, "n_cols": 4, "ref": "#/tables/0", "reading_order": 1 }, { "page": 24, "type": "TEXT", "location": { "l": 38.88, "t": 146.16, "r": 725.52, "b": 68.4 }, "text": "a Grand mean LC 50 value of 1.2 ppm ± 0.30 ppm.b Twig samples were collected, September 26, 1995, from trees planted in the spring of 1984.", "reading_order": 2 }, { "page": 24, "type": "TEXT", "location": { "l": 595.92, "t": 24.72, "r": 720.96, "b": 2.4 }, "text": "M cL aughlin, 2008", "reading_order": 3 } ] }, { "page": 25, "items": [ { "page": 25, "type": "TITLE", "location": { "l": 71.04, "t": 470.88, "r": 245.28, "b": 423.84 }, "text": "Summary", "reading_order": 0, "level": 3 }, { "page": 25, "type": "TEXT", "location": { "l": 69.84, "t": 389.76, "r": 709.44, "b": 315.6 }, "text": "We are screening current paw paw cultivars for acetogenin activity:", "reading_order": 1 }, { "page": 25, "type": "TEXT", "location": { "l": 114, "t": 306.96, "r": 679.68, "b": 241.92 }, "text": "High: NC-1, Overleese, Mitchell, Middletown, Susquehanna,...", "reading_order": 2 }, { "page": 25, "type": "TEXT", "location": { "l": 114, "t": 232.8, "r": 711.36, "b": 169.2 }, "text": "Low: Sunflower, W abash, Potomac, Zimmerman, Wells,...", "reading_order": 3 }, { "page": 25, "type": "TEXT", "location": { "l": 69.84, "t": 156.48, "r": 710.4, "b": 43.44 }, "text": "In the KSU pawpaw breeding program, we are selecting both high and low acetogenin genotypes.", "reading_order": 4 } ] }, { "page": 26, "items": [ { "page": 26, "type": "TEXT", "location": { "l": 237.6, "t": 301.44, "r": 454.32, "b": 246.72 }, "text": "Questions?", "reading_order": 0 } ] } ]