Champy et al. (2005) determined the concentrations of annonacin, the major acetogenin in soursop.
An average fruit contains about 15 mg of annonacin.
When directly injecting rats for one month with the estimated amounts of annonacin ingested in a year by eating one fruit daily, this induced neurodegeneration in the basal ganglia and mesencephalon (Champy et al., 2004).
Purified extract and bioavailability upon digestion not examined.