Table 1. The bioactivities of bullatacin in the brine shrimp test and human solid tumor cell lines.
| Compound | BST LC50 (μ g/ml) | ED50 (μ g/ml) | MCF-7 ED50 (μ g/ml) | HT-29 ED50 (μ g/ml) |
|---|
| Bullatacin | 1.59 × 10-3 | 1.25 × 10-13 | >10 | 1.0 × 10-12 |
| Adriamycin | 2.57 × 10-1 | 1.04 × 10-4 | 1.76 × 10-2 | 1.53 × 10-4 |
Adriamycin textcircled R = standard anticarcinoma drug
ED 50 = effective dose resulting in 50% cell death
A -549 = human hung carcinorma
MCF -7 = human breast carcinoma
HT-29 = human colon carcinoma
LC 50 = lethal concentration resulting in 50% deaths
Bullatacin inhibits mammalian solid tumor cells at concentrations often a billion times lower than A driamycin., as shown in Table 1 (Zhao, et al. 1994b).