What is PrEP: first questions

What is PrEP?

PrEP stands for Pre-Exposure Prophylaxis.

PrEP is taken before sex, so it is pre-exposure. But it also needs to be taken afterwards too. Prophylaxis means to prevent infection. More than 86,000 people in the UK already use PrEP.

PrEP usually contains two HIV drugs in a single pill. This is usually TD (tenofovir disoproxil) plus FTC. A version using TAF (tenofovir alafenamide) instead of TD is used by the NHS if you have kidney or bone issues. Generic TAF/FTC can also be bought cheaply online, see p11.

During 2024, PrEP using a 2-monthly injection of cabotegravir is being assessed for approval in the UK. Studies are also ongoing using a 6-monthly injection of lenacapavir.

Who can take PrEP?

Anyone who is HIV negative and who could benefit from PrEP should now be able to access it.

PrEP is especially important if you have used PEP, had a recent STI, have chemsex or have partners with these risks.

You do NOT need PrEP if you are HIV negative and...

• You are happy and able to always use condoms.
• You only have sex with HIV positive people who are on HIV treatment and who have an undetectable viral load.
• You don't use condoms but your partner is low risk.

February 2024