{
    "document_id": 251,
    "page": 12,
    "width_pt": 595.32,
    "height_pt": 841.92,
    "engine": "paddleocr_vl",
    "source_run_id": 376,
    "item_count": 26,
    "counts_by_type": {
        "caption": 1,
        "footer": 2,
        "header": 2,
        "heading": 2,
        "link": 1,
        "list": 1,
        "list_item": 4,
        "table": 1,
        "table_cell": 8,
        "text": 4
    },
    "build_ms": 4,
    "items": [
        {
            "id": "p12.1",
            "order": 1,
            "type": "header",
            "bbox": {
                "l": 42.2315,
                "t": 800.4,
                "r": 253.149,
                "b": 784.8
            },
            "text": "Oxford University Hospitals NHS FT",
            "attrs": {
                "block_label": "header"
            }
        },
        {
            "id": "p12.2",
            "order": 2,
            "type": "header",
            "bbox": {
                "l": 457.1079,
                "t": 800.16,
                "r": 522.8546,
                "b": 785.52
            },
            "text": "TB2026.67",
            "attrs": {
                "block_label": "header"
            }
        },
        {
            "id": "p12.3",
            "order": 3,
            "type": "text",
            "bbox": {
                "l": 143.731,
                "t": 769.68,
                "r": 517.0958,
                "b": 738.72
            },
            "text": "studies will be taking place outside of acute Trusts, which is expected to increase demand for OUH to provide services to these studies."
        },
        {
            "id": "p12.4",
            "order": 4,
            "type": "caption",
            "bbox": {
                "l": 69.586,
                "t": 710.4,
                "r": 285.5424,
                "b": 695.28
            },
            "text": "Table 4. Summary of activity in 2025-26",
            "attrs": {
                "block_label": "figure_title"
            }
        },
        {
            "id": "p12.5",
            "order": 5,
            "type": "table",
            "bbox": {
                "l": 98.6201,
                "t": 689.28,
                "r": 496.22,
                "b": 555.6
            },
            "text": "",
            "attrs": {
                "block_label": "table",
                "n_rows": 2,
                "n_cols": 4,
                "integrity": {
                    "cells_checked": 7,
                    "cells_flagged": 0
                }
            },
            "children": [
                {
                    "id": "p12.5.1",
                    "order": 6,
                    "type": "table_cell",
                    "bbox": {
                        "l": 98.6201,
                        "t": 689.28,
                        "r": 198.0201,
                        "b": 672.57
                    },
                    "text": "",
                    "attrs": {
                        "row": 0,
                        "col": 0,
                        "rowspan": 1,
                        "colspan": 1,
                        "column_header": true,
                        "header_source": "pdf"
                    }
                },
                {
                    "id": "p12.5.2",
                    "order": 7,
                    "type": "table_cell",
                    "bbox": {
                        "l": 219.24,
                        "t": 685.4159999999999,
                        "r": 281.999724,
                        "b": 660.3599999999999
                    },
                    "text": "Participants recruited",
                    "attrs": {
                        "row": 0,
                        "col": 1,
                        "rowspan": 1,
                        "colspan": 1,
                        "bbox_refit": true,
                        "column_header": true,
                        "header_source": "pdf"
                    }
                },
                {
                    "id": "p12.5.3",
                    "order": 8,
                    "type": "table_cell",
                    "bbox": {
                        "l": 299.04,
                        "t": 685.4159999999999,
                        "r": 372.456082,
                        "b": 660.3599999999999
                    },
                    "text": "Studies open to recruitment",
                    "attrs": {
                        "row": 0,
                        "col": 2,
                        "rowspan": 1,
                        "colspan": 1,
                        "bbox_refit": true,
                        "column_header": true,
                        "header_source": "pdf"
                    }
                },
                {
                    "id": "p12.5.4",
                    "order": 9,
                    "type": "table_cell",
                    "bbox": {
                        "l": 387,
                        "t": 685.4159999999999,
                        "r": 487.17582,
                        "b": 660.3599999999999
                    },
                    "text": "New studies approved to recruit",
                    "attrs": {
                        "row": 0,
                        "col": 3,
                        "rowspan": 1,
                        "colspan": 1,
                        "bbox_refit": true,
                        "column_header": true,
                        "header_source": "pdf"
                    }
                },
                {
                    "id": "p12.5.5",
                    "order": 10,
                    "type": "table_cell",
                    "bbox": {
                        "l": 104.64,
                        "t": 657.336,
                        "r": 202.104098,
                        "b": 556.8
                    },
                    "text": "Commercial\nNon-Commercial\nInterventional\nNon-interventional\nNIHR portfolio\nNon-portfolio\nTotals",
                    "attrs": {
                        "row": 1,
                        "col": 0,
                        "rowspan": 1,
                        "colspan": 1,
                        "bbox_refit": true,
                        "merged_continuation": true
                    }
                },
                {
                    "id": "p12.5.6",
                    "order": 11,
                    "type": "table_cell",
                    "bbox": {
                        "l": 219,
                        "t": 657.336,
                        "r": 287.915595,
                        "b": 556.8
                    },
                    "text": "856 (6%)\n12683 (94%)\n5133 (38%)\n8406 (62%)\n10103 (75%)\n3436 (25%)\n13539",
                    "attrs": {
                        "row": 1,
                        "col": 1,
                        "rowspan": 1,
                        "colspan": 1,
                        "bbox_refit": true,
                        "merged_continuation": true
                    }
                },
                {
                    "id": "p12.5.7",
                    "order": 12,
                    "type": "table_cell",
                    "bbox": {
                        "l": 317.52,
                        "t": 657.336,
                        "r": 372.996089,
                        "b": 556.8
                    },
                    "text": "209 (22%)\n753 (78%)\n434 (45%)\n528 (55%)\n751 (78%)\n211 (22%)\n962",
                    "attrs": {
                        "row": 1,
                        "col": 2,
                        "rowspan": 1,
                        "colspan": 1,
                        "bbox_refit": true,
                        "merged_continuation": true
                    }
                },
                {
                    "id": "p12.5.8",
                    "order": 13,
                    "type": "table_cell",
                    "bbox": {
                        "l": 435.36,
                        "t": 657.336,
                        "r": 490.836059,
                        "b": 556.8
                    },
                    "text": "110 (35%)\n203 (65%)\n172 (55%)\n141 (45%)\n254 (81%)\n59 (19%)\n313",
                    "attrs": {
                        "row": 1,
                        "col": 3,
                        "rowspan": 1,
                        "colspan": 1,
                        "bbox_refit": true,
                        "merged_continuation": true
                    }
                }
            ]
        },
        {
            "id": "p12.6",
            "order": 14,
            "type": "heading",
            "bbox": {
                "l": 69.1061,
                "t": 531.84,
                "r": 282.903,
                "b": 516.24
            },
            "text": "4. Clinical Research Performance",
            "attrs": {
                "block_label": "paragraph_title"
            }
        },
        {
            "id": "p12.7",
            "order": 15,
            "type": "heading",
            "bbox": {
                "l": 70.0659,
                "t": 508.56,
                "r": 144.9308,
                "b": 493.92
            },
            "text": "Background",
            "attrs": {
                "block_label": "paragraph_title"
            }
        },
        {
            "id": "p12.8",
            "order": 16,
            "type": "text",
            "bbox": {
                "l": 110.8577,
                "t": 486.72,
                "r": 519.4953,
                "b": 424.32
            },
            "text": "4.1. The government's target was to reduce to less than 150 days the time it takes to set up a clinical trial, by March 2026. The 150-day target applies to all clinical trials, with a focus on commercial interventional clinical trials, at study level. It comprises three stages:"
        },
        {
            "id": "p12.9",
            "order": 17,
            "type": "list",
            "bbox": {
                "l": 140.3717,
                "t": 417.65989999999994,
                "r": 523.0946,
                "b": 340.08
            },
            "text": "",
            "attrs": {
                "item_count": 3
            },
            "children": [
                {
                    "id": "p12.9.1",
                    "order": 18,
                    "type": "list_item",
                    "bbox": {
                        "l": 141.0916,
                        "t": 417.65989999999994,
                        "r": 523.0946,
                        "b": 385.92
                    },
                    "text": "• Medicines & Healthcare products Regulatory Agency and Research Ethics Committee combined review decision - target is 60 days."
                },
                {
                    "id": "p12.9.2",
                    "order": 19,
                    "type": "list_item",
                    "bbox": {
                        "l": 140.3717,
                        "t": 379.14,
                        "r": 497.6597,
                        "b": 363.12
                    },
                    "text": "• Combined review decision to study opening - target is 60 days."
                },
                {
                    "id": "p12.9.3",
                    "order": 20,
                    "type": "list_item",
                    "bbox": {
                        "l": 141.3315,
                        "t": 356.45989999999995,
                        "r": 487.1018,
                        "b": 340.08
                    },
                    "text": "- Study opening to first participant recruited - target is 30 days."
                }
            ]
        },
        {
            "id": "p12.10",
            "order": 21,
            "type": "text",
            "bbox": {
                "l": 110.8577,
                "t": 333.84,
                "r": 521.1749,
                "b": 207.12
            },
            "text": "4.2. In April 2026 $ the DHSC announced $ that average set-up time for commercial clinical trials in the UK reduced to 122 days, down from 169 the previous year, surpassing the 150-day target, which is now regarded as a milestone rather than an endpoint, at a study level. This has been attributed to a combination of reduced bureaucracy, standardised processes and investment (~£137m) in research infrastructure, with 99% of studies now receiving regulatory approvals within the 60-day target.",
            "children": [
                {
                    "type": "link",
                    "bbox": {
                        "l": 214.32,
                        "t": 311.51,
                        "r": 333.38,
                        "b": 294.67
                    },
                    "text": "the DHSC announced",
                    "attrs": {
                        "source": "ai_vision",
                        "reason": "Hyperlink text rendered in blue underline is not extracted as a link item."
                    },
                    "children": [],
                    "order": 22,
                    "id": "p12.10.1"
                }
            ]
        },
        {
            "id": "p12.11",
            "order": 23,
            "type": "text",
            "bbox": {
                "l": 111.3376,
                "t": 200.88,
                "r": 514.4563,
                "b": 153.6
            },
            "text": "4.3. There is an accompanying expectation that all participating trial sites (like OUH) must complete their set-up activities within 90 days, comprising two stages:"
        },
        {
            "id": "p12.12",
            "order": 24,
            "type": "list_item",
            "bbox": {
                "l": 140.8516,
                "t": 147.18009999999992,
                "r": 515.1762,
                "b": 82.8
            },
            "text": "- Regulatory approval (Health Research Authority) or Date Site Selected, whichever comes later, to site confirmed (i.e. contract signed) - target is 60 days. During this time the Site has to confirm feasibility (clinically and operationally); agree the budget (NCVR);"
        },
        {
            "id": "p12.13",
            "order": 25,
            "type": "footer",
            "bbox": {
                "l": 41.7516,
                "t": 50.4,
                "r": 401.919,
                "b": 36.48
            },
            "text": "Research & Development Governance and Performance Report 2025-26",
            "attrs": {
                "block_label": "footer"
            }
        },
        {
            "id": "p12.14",
            "order": 26,
            "type": "footer",
            "bbox": {
                "l": 451.589,
                "t": 49.92,
                "r": 523.0946,
                "b": 36.24
            },
            "text": "Page 12 of 38",
            "attrs": {
                "block_label": "number"
            }
        }
    ],
    "ai_vision": {
        "model": "claude-opus-5",
        "confidence": 72,
        "added": 1,
        "retyped": 0
    }
}