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            "text": "Reminder: Health →\nA Result of Many Factors + Exposures\nExample Cardiovascular Disease",
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                    "bbox": {
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                    "text": "Genetic predisposition"
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                    "id": "p54.2.2",
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                    "type": "heading",
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                    "text": "Major exposome\nrisk factors",
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                    "id": "p54.2.3",
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                    "text": "Pre-existing cardiovascular disease"
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                    "text": "Increased cardiovascular\nrisk and morbidity",
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                    "level": 3
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                    "id": "p54.2.5",
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                    "text": "Central biochemical pathways",
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                    "id": "p54.2.6",
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                    "text": "Smoking"
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                {
                    "id": "p54.2.7",
                    "order": 9,
                    "type": "text",
                    "bbox": {
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                        "t": 311.76,
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                    "text": "- Circadian clock dysregulation\n- Stress hormone responses\n- Inflammation\n- Oxidative stress"
                },
                {
                    "id": "p54.2.8",
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                    "type": "heading",
                    "bbox": {
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                        "r": 269.52,
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                    "text": "Specific external environment",
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                    "level": 3
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                    "id": "p54.2.9",
                    "order": 11,
                    "type": "text",
                    "bbox": {
                        "l": 331.92,
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                    "text": "• Inflammation"
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                {
                    "id": "p54.2.10",
                    "order": 12,
                    "type": "text",
                    "bbox": {
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                    "text": "Mental health and societal factors"
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                    "id": "p54.2.11",
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                    "type": "text",
                    "bbox": {
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                        "r": 168.48,
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                    "text": "- Diet\n- Consumer products\n- Physical activity\n- Tobacco\n- Water"
                },
                {
                    "id": "p54.2.12",
                    "order": 14,
                    "type": "text",
                    "bbox": {
                        "l": 331.92,
                        "t": 259.92,
                        "r": 412.08,
                        "b": 249.12
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                    "text": "• Oxidative stress"
                },
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                    "id": "p54.2.13",
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                    "type": "text",
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                        "l": 137.04,
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                    "text": "• Consumer products"
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                    "type": "text",
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                    "text": "• Psychosocial stress • Tobacco"
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                    "text": "Lonliness Water"
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                    "id": "p54.2.16",
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                    "type": "heading",
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                        "l": 330.96,
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                    "text": "Internal environment",
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                    "id": "p54.2.17",
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                    "text": "Health effects and risk assessments",
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                    "level": 3
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                {
                    "id": "p54.2.18",
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                    "bbox": {
                        "l": 27.84,
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                    "text": "• Social isolation"
                },
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                    "id": "p54.2.19",
                    "order": 21,
                    "type": "text",
                    "bbox": {
                        "l": 657.12,
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                    "text": "Myocardial infarction"
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                {
                    "id": "p54.2.20",
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                    "type": "text",
                    "bbox": {
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                    "text": "• Transcriptomics\n• Proteomics\n• Metabolomics\n• Proteomics\n• Metabolomics"
                },
                {
                    "id": "p54.2.21",
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                    "type": "heading",
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                    "text": "General external environment",
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                    "text": "• Climate\n• Traffic\n• Urban environment\n• Green spaces\nTraffic"
                },
                {
                    "id": "p54.2.23",
                    "order": 25,
                    "type": "text",
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                    "text": "Chemical pollution"
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                    "text": "• Urban environment"
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                    "text": "• Air\n• Water\n• Soil"
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                    "type": "text",
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                    "text": "Stroke"
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                    "text": "Green spaces\n\n• Green spaces"
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                    "text": "Water"
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                    "id": "p54.2.29",
                    "order": 31,
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                    "bbox": {
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                    "text": "Life course dimension"
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            ]
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                    "text": "Anxiety",
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                    "text": "[F23]",
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                    },
                    "text": "[F8]",
                    "attrs": {
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            ]
        },
        {
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            "text": "Plaque",
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        {
            "id": "p54.6",
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            "id": "p54.7",
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            "text": "(Daiber, et al., 2025)",
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            "text": "54 of 113",
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