{ "document_id": 14408, "page": 35, "width_pt": 612, "height_pt": 792, "rotation": 0, "pipeline_version": "paddleocr-vl-1.6+paul-48", "engine": "paddleocr_vl", "source_run_id": 14519, "item_count": 84, "counts_by_type": { "caption": 1, "figure": 2, "formula": 8, "header": 3, "heading": 1, "table": 1, "table_cell": 18, "text": 50 }, "build_ms": 12, "items": [ { "id": "p35.1", "order": 1, "type": "header", "bbox": { "l": 53.52, "t": 765.6, "r": 70.8, "b": 756.96 }, "text": "538", "attrs": { "block_label": "number" }, "level": 2 }, { "id": "p35.2", "order": 2, "type": "header", "bbox": { "l": 75.6, "t": 766.08, "r": 264.48, "b": 756 }, "text": "Journal of Natural Products, 1999, Vol. 62, No. 3", "attrs": { "block_label": "header" }, "level": 2 }, { "id": "p35.3", "order": 3, "type": "header", "bbox": { "l": 501.12, "t": 766.08, "r": 559.92, "b": 756 }, "text": "Invited Review", "attrs": { "block_label": "header" }, "level": 2 }, { "id": "p35.4", "order": 4, "type": "heading", "bbox": { "l": 53.28, "t": 746.16, "r": 143.04, "b": 736.08 }, "text": "Table 4. (Continued)", "attrs": { "block_label": "paragraph_title" }, "level": 3 }, { "id": "p35.5", "order": 5, "type": "text", "bbox": { "l": 69.6, "t": 734.4, "r": 385.92, "b": 717.36 }, "text": "Non-THF or THP Acetogenins (Continued)\n131. diepomuricanin B[p35.5.1] (C [p35.5.2]H [p35.5.3]O[p35.5.4], MW546)", "children": [ { "id": "p35.5.1", "order": 6, "type": "text", "bbox": { "l": 69.6, "t": 734.4, "r": 385.92, "b": 717.36 }, "text": "¹³²", "attrs": { "inline": true, "text_offset": 60, "text_span": 9, "bbox_estimated": true } }, { "id": "p35.5.2", "order": 7, "type": "text", "bbox": { "l": 69.6, "t": 734.4, "r": 385.92, "b": 717.36 }, "text": "₃₅", "attrs": { "inline": true, "text_offset": 73, "text_span": 9, "bbox_estimated": true } }, { "id": "p35.5.3", "order": 8, "type": "text", "bbox": { "l": 69.6, "t": 734.4, "r": 385.92, "b": 717.36 }, "text": "₆₂", "attrs": { "inline": true, "text_offset": 84, "text_span": 9, "bbox_estimated": true } }, { "id": "p35.5.4", "order": 9, "type": "text", "bbox": { "l": 69.6, "t": 734.4, "r": 385.92, "b": 717.36 }, "text": "₄", "attrs": { "inline": true, "text_offset": 94, "text_span": 9, "bbox_estimated": true } } ] }, { "id": "p35.6", "order": 10, "type": "formula", "bbox": { "l": 153.12, "t": 717.6, "r": 457.44, "b": 627.36 }, "text": "", "attrs": { "block_label": "image", "alt": "Skeletal structure of an annonaceous acetogenin with a butenolide ring, two epoxides on a long chain, and numbered carbons 1…", "source": "vision" } }, { "id": "p35.7", "order": 11, "type": "text", "bbox": { "l": 70.32, "t": 628.08, "r": 540.48, "b": 600.96 }, "text": "White wax. [α]D: +10° (c 0.75, CHCl₃). UV (λmax, MeOH, nm): 208 IR (νmax, film, cm⁻¹): 3400, 2910, 2845, 1745. MS: EIMS m/z 323, 293, 279, 97. NMR: ¹H NMR (200 MHz, CDCl₃), ¹³C NMR (50 MHz, CDCl₃). Source: Rollinia membranacea, seeds. 132. tonkinelin¹³³ (C₃₇H₇₀O₄, MW 578)" }, { "id": "p35.8", "order": 12, "type": "formula", "bbox": { "l": 149.52, "t": 600.96, "r": 459.84, "b": 513.12 }, "text": "", "attrs": { "block_label": "image", "alt": "Skeletal structure of an annonaceous acetogenin: butenolide ring with a long chain bearing threo 17,18-diol", "source": "vision" } }, { "id": "p35.9", "order": 13, "type": "formula", "bbox": { "l": 153.6, "t": 521.76, "r": 248.88, "b": 512.4 }, "text": "\\mathrm{}^{13}\\mathrm{C}~(\\delta)~\\quad74.53\\quad74.53", "attrs": { "block_label": "display_formula", "latex": "\\mathrm{}^{13}\\mathrm{C}~(\\delta)~\\quad74.53\\quad74.53", "notation": "latex", "alt": "to the power of 13 C of delta 74.53 74.53", "mathml": "13C (δ) 74.5374.53" } }, { "id": "p35.10", "order": 14, "type": "text", "bbox": { "l": 72.48, "t": 512.64, "r": 528.96, "b": 474.72 }, "text": "White amorphous powder. Mp: 64–66°C. [α]D: +14.5° (c O,07, CHCl₃). IR (νmax, film, cm⁻¹): 3341, 2915, 2848, 1742, 1469. MS: EIMS m/z 579, 561, 543, 335, 323, 209, 195, 181, 167, 153, 139, 125, 111, 97. NMR: ¹H NMR (500MHz, CDCl₃), ¹³C NMR (125MHz, CDCl₃). Derivatives: acetonide (¹H NMR), TMS (EIMS). Biological activities (μg/mL): HL-60IC₅₀\n1,0, HCT-8IC₅₀, 6,7, KB IC₅₀ > 10, A2780IC₅₀ > 10. Source: Uvaria tonkinesis, root bark." }, { "id": "p35.11", "order": 15, "type": "text", "bbox": { "l": 69.12, "t": 477.36, "r": 205.92, "b": 468.24 }, "text": "133. annoijahnin[p35.11.1] (C [p35.11.2]H [p35.11.3]O[p35.11.4], MW", "children": [ { "id": "p35.11.1", "order": 16, "type": "formula", "bbox": { "l": 69.12, "t": 477.36, "r": 205.92, "b": 468.24 }, "text": "¹²", "attrs": { "latex": "^{12}", "inline": true, "text_offset": 16, "text_span": 10, "bbox_estimated": true, "alt": "to the power of 12", "mathml": "12" } }, { "id": "p35.11.2", "order": 17, "type": "text", "bbox": { "l": 69.12, "t": 477.36, "r": 205.92, "b": 468.24 }, "text": "₃₅", "attrs": { "inline": true, "text_offset": 30, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.11.3", "order": 18, "type": "text", "bbox": { "l": 69.12, "t": 477.36, "r": 205.92, "b": 468.24 }, "text": "₆₆", "attrs": { "inline": true, "text_offset": 42, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.11.4", "order": 19, "type": "text", "bbox": { "l": 69.12, "t": 477.36, "r": 205.92, "b": 468.24 }, "text": "₅", "attrs": { "inline": true, "text_offset": 53, "text_span": 10, "bbox_estimated": true } } ] }, { "id": "p35.12", "order": 20, "type": "figure", "bbox": { "l": 151.68, "t": 469.68, "r": 457.68, "b": 378.96 }, "text": "", "attrs": { "block_label": "image" }, "children": [ { "id": "p35.12.1", "order": 21, "type": "text", "bbox": { "l": 155.04, "t": 413.76, "r": 353.04, "b": 402.48 }, "text": "Position 10 17 18 21 22" } ] }, { "id": "p35.13", "order": 22, "type": "text", "bbox": { "l": 71.04, "t": 378.96, "r": 532.8, "b": 330.48 }, "text": "Waxy solid. Mp: 70–72°C. [α]D: +15.0° (c 0.008, MeOH). UV (λmax, MeOH, nm): 220 (log ε 3.53). IR (νmax, film, cm⁻¹): 3360, 2918, 2897, 1737, 1703, 1648, 1467, 1282, 1199, 669. MS: EIMS m/z 367, 337, 319, 307, 283, 265, 253, 235, 223, 125, 97. NMR: ¹H NMR (500 MHz, CDCl₃), ¹³C NMR (125 MHz, CDCl₃). Derivatives: acetonide (¹H NMR), per-MTPA esters (¹H NMR). Biological activities (μg/mL): BST LC₅₀ 1.1 × 10¹, A-549 ED₅₀ 1.5, MCF-7 ED₅₀ 2.8, HT-29 ED₅₀ 5.9 × 10⁻², A-498 ED₅₀ 4.9, PC-3 ED₅₀ 1.6 × 10⁻², PACA-2 ED₅₀ 2.3 × 10⁻². Source: Annona jahnii, twigs." }, { "id": "p35.14", "order": 23, "type": "caption", "bbox": { "l": 257.04, "t": 329.52, "r": 354.48, "b": 320.64 }, "text": "Nonclassical Acetogenins", "attrs": { "block_label": "figure_title" } }, { "id": "p35.15", "order": 24, "type": "figure", "bbox": { "l": 153.36, "t": 313.68, "r": 457.2, "b": 220.08 }, "text": "", "attrs": { "block_label": "image" }, "children": [ { "id": "p35.15.1", "order": 25, "type": "text", "bbox": { "l": 155.04, "t": 255.84, "r": 389.52, "b": 240.72 }, "text": "Position 12 13 17 18 21 22" }, { "id": "p35.15.2", "order": 26, "type": "text", "bbox": { "l": 154.8, "t": 239.52, "r": 389.52, "b": 219.84 }, "text": "[p35.15.2.1]H (δ) 3.43 m 3.16 m 3.31 m 3.90 m 3.80 m 3.38 m\n [p35.15.2.2]C (δ) 74.2 80.9 80.0 81.2 82.8 74.1", "children": [ { "id": "p35.15.2.1", "order": 27, "type": "formula", "bbox": { "l": 154.8, "t": 239.52, "r": 389.52, "b": 219.84 }, "text": "¹", "attrs": { "latex": "^{1}", "inline": true, "text_offset": 0, "text_span": 12, "bbox_estimated": true, "alt": "to the power of 1", "mathml": "1" } }, { "id": "p35.15.2.2", "order": 28, "type": "formula", "bbox": { "l": 154.8, "t": 239.52, "r": 389.52, "b": 219.84 }, "text": "¹³", "attrs": { "latex": "^{13}", "inline": true, "text_offset": 61, "text_span": 12, "bbox_estimated": true, "alt": "to the power of 13", "mathml": "13" } } ] } ] }, { "id": "p35.16", "order": 29, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "White wax. MS: EIMS m/z 405, 387, 353, 335, 317, 269, 141. NMR: [p35.16.1]H NMR (500 MHz, CDCl[p35.16.2]), [p35.16.3]C NMR (125 MHz, CDCl[p35.16.4]). Derivatives: per-MTPA esters ( [p35.16.5]H NMR), TMS (EIMS). Biological activities ( [p35.16.6]g/mL): A-549 ED[p35.16.7] 4.5 × 10[p35.16.8], MCF-7 ED[p35.16.9] 2.4 × 10[p35.16.10], HT-29 ED[p35.16.11] 3.9 × 10[p35.16.12], A-498 ED[p35.16.13] 1.8 × 10[p35.16.14], PC-3 ED[p35.16.15] 5.8 × 10[p35.16.16], PAC-2 ED[p35.16.17] 5.4 × 10[p35.16.18]. Source: Rollinia mucosa leaves.\n135. pyranicin[p35.16.19] ([p35.16.20], MW596)", "children": [ { "id": "p35.16.1", "order": 30, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "¹", "attrs": { "inline": true, "text_offset": 64, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.16.2", "order": 31, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "₃", "attrs": { "inline": true, "text_offset": 94, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.16.3", "order": 32, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "¹³", "attrs": { "inline": true, "text_offset": 107, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.16.4", "order": 33, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "₃", "attrs": { "inline": true, "text_offset": 137, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.16.5", "order": 34, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "¹", "attrs": { "inline": true, "text_offset": 181, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.16.6", "order": 35, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "μ", "attrs": { "inline": true, "text_offset": 235, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.16.7", "order": 36, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 260, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.16.8", "order": 37, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "⁻³", "attrs": { "inline": true, "text_offset": 279, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.16.9", "order": 38, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 299, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.16.10", "order": 39, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "⁻⁴", "attrs": { "inline": true, "text_offset": 318, "text_span": 11, "bbox_estimated": true } }, { "id": "p35.16.11", "order": 40, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 339, "text_span": 11, "bbox_estimated": true } }, { "id": "p35.16.12", "order": 41, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "⁻¹", "attrs": { "inline": true, "text_offset": 359, "text_span": 11, "bbox_estimated": true } }, { "id": "p35.16.13", "order": 42, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 380, "text_span": 11, "bbox_estimated": true } }, { "id": "p35.16.14", "order": 43, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "⁻¹", "attrs": { "inline": true, "text_offset": 400, "text_span": 11, "bbox_estimated": true } }, { "id": "p35.16.15", "order": 44, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 420, "text_span": 11, "bbox_estimated": true } }, { "id": "p35.16.16", "order": 45, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "⁻¹", "attrs": { "inline": true, "text_offset": 440, "text_span": 11, "bbox_estimated": true } }, { "id": "p35.16.17", "order": 46, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 461, "text_span": 11, "bbox_estimated": true } }, { "id": "p35.16.18", "order": 47, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "⁻⁴", "attrs": { "inline": true, "text_offset": 481, "text_span": 11, "bbox_estimated": true } }, { "id": "p35.16.19", "order": 48, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "¹⁰", "attrs": { "inline": true, "text_offset": 540, "text_span": 11, "bbox_estimated": true } }, { "id": "p35.16.20", "order": 49, "type": "text", "bbox": { "l": 71.76, "t": 220.32, "r": 535.2, "b": 186 }, "text": "C₃₅H₆₄O₇", "attrs": { "inline": true, "text_offset": 553, "text_span": 11, "bbox_estimated": true } } ] }, { "id": "p35.17", "order": 50, "type": "formula", "bbox": { "l": 163.68, "t": 175.44, "r": 448.32, "b": 127.44 }, "text": "", "attrs": { "block_label": "image", "alt": "Skeletal structure of an annonaceous acetogenin-type butenolide with hydroxyls at C4, C10, C15, C19 and a THF ether at C15-C…", "source": "vision" } }, { "id": "p35.18", "order": 51, "type": "table", "bbox": { "l": 162.72, "t": 118.08, "r": 366.48, "b": 80.16 }, "text": "", "attrs": { "block_label": "table", "n_rows": 3, "n_cols": 6, "integrity": { "skipped": "no_text_layer" } }, "children": [ { "id": "p35.18.1", "order": 52, "type": "table_cell", "bbox": { "l": 162.72, "t": 118.08, "r": 196.68, "b": 105.44 }, "text": "Position", "attrs": { "row": 0, "col": 0, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p35.18.2", "order": 53, "type": "table_cell", "bbox": { "l": 196.68, "t": 118.08, "r": 230.64, "b": 105.44 }, "text": "10", "attrs": { "row": 0, "col": 1, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p35.18.3", "order": 54, "type": "table_cell", "bbox": { "l": 230.64, "t": 118.08, "r": 264.6, "b": 105.44 }, "text": "15", "attrs": { "row": 0, "col": 2, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p35.18.4", "order": 55, "type": "table_cell", "bbox": { "l": 264.6, "t": 118.08, "r": 298.56, "b": 105.44 }, "text": "16", "attrs": { "row": 0, "col": 3, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p35.18.5", "order": 56, "type": "table_cell", "bbox": { "l": 298.56, "t": 118.08, "r": 332.52, "b": 105.44 }, "text": "19", "attrs": { "row": 0, "col": 4, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p35.18.6", "order": 57, "type": "table_cell", "bbox": { "l": 332.52, "t": 118.08, "r": 366.48, "b": 105.44 }, "text": "20", "attrs": { "row": 0, "col": 5, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p35.18.7", "order": 58, "type": "table_cell", "bbox": { "l": 162.72, "t": 105.44, "r": 196.68, "b": 92.8 }, "text": "¹H ( δ)", "attrs": { "row": 1, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p35.18.8", "order": 59, "type": "table_cell", "bbox": { "l": 196.68, "t": 105.44, "r": 230.64, "b": 92.8 }, "text": "3.60 m", "attrs": { "row": 1, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p35.18.9", "order": 60, "type": "table_cell", "bbox": { "l": 230.64, "t": 105.44, "r": 264.6, "b": 92.8 }, "text": "3.46 dt", "attrs": { "row": 1, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p35.18.10", "order": 61, "type": "table_cell", "bbox": { "l": 264.6, "t": 105.44, "r": 298.56, "b": 92.8 }, "text": "3.19 ddd", "attrs": { "row": 1, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p35.18.11", "order": 62, "type": "table_cell", "bbox": { "l": 298.56, "t": 105.44, "r": 332.52, "b": 92.8 }, "text": "3.61 m", "attrs": { "row": 1, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p35.18.12", "order": 63, "type": "table_cell", "bbox": { "l": 332.52, "t": 105.44, "r": 366.48, "b": 92.8 }, "text": "3.34 ddd", "attrs": { "row": 1, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p35.18.13", "order": 64, "type": "table_cell", "bbox": { "l": 162.72, "t": 92.8, "r": 196.68, "b": 80.16 }, "text": "¹³C ( δ)", "attrs": { "row": 2, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p35.18.14", "order": 65, "type": "table_cell", "bbox": { "l": 196.68, "t": 92.8, "r": 230.64, "b": 80.16 }, "text": "71.7", "attrs": { "row": 2, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p35.18.15", "order": 66, "type": "table_cell", "bbox": { "l": 230.64, "t": 92.8, "r": 264.6, "b": 80.16 }, "text": "73.9", "attrs": { "row": 2, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p35.18.16", "order": 67, "type": "table_cell", "bbox": { "l": 264.6, "t": 92.8, "r": 298.56, "b": 80.16 }, "text": "81.1", "attrs": { "row": 2, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p35.18.17", "order": 68, "type": "table_cell", "bbox": { "l": 298.56, "t": 92.8, "r": 332.52, "b": 80.16 }, "text": "66.1", "attrs": { "row": 2, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p35.18.18", "order": 69, "type": "table_cell", "bbox": { "l": 332.52, "t": 92.8, "r": 366.48, "b": 80.16 }, "text": "80.0", "attrs": { "row": 2, "col": 5, "rowspan": 1, "colspan": 1 } } ] }, { "id": "p35.19", "order": 70, "type": "text", "bbox": { "l": 71.04, "t": 81.12, "r": 531.84, "b": 35.76 }, "text": "White amorphous wax.[p35.19.1]: -9.7° (c 0.008, CHCl_{3}). UV ([p35.19.2], MeOH, nm): 216 ([p35.19.3] 3.32). IR ([p35.19.4], film, cm^{-1}): 3418, 2928, 2854, 1748, 1456, 1319, 1086. MS: EIMS m/z 426, 309, 291, 273, 269, 251, 241, 223, 205, 141. NMR: [p35.19.5]H NMR (500 MHz, CDCl_{3}), [p35.19.6]C NMR (125 MHz, CDCl_{3}). Derivatives: per-MTPA esters ( [p35.19.7]H NMR). Biological activities ( [p35.19.8]g/mL): BST LC_{50} 3[p35.19.9] 10^{-1}, A-549 ED_{50} 2.8[p35.19.10] 10^{-1}, MCF-7 ED_{50} 3.9[p35.19.11] 10^{-1}, HT-29 ED_{50} 1.2, A-498 ED_{50} 1.8[p35.19.12] 10^{-1}, PC-3 ED_{50} 4.1[p35.19.13] 10^{-1}, PACA-2 ED_{50} 1.3[p35.19.14] 10^{-3}. Source: Goniothalamus giganteus, stem bark.", "children": [ { "id": "p35.19.1", "order": 71, "type": "formula", "bbox": { "l": 71.04, "t": 81.12, "r": 531.84, "b": 35.76 }, "text": "\\text{White amorphous wax. } [\\alpha]_{D}: -9.7^\\circ (c\\ 0.008, \\text{CHCl}_3). \\text{UV } (\\lambda_{\\max}, \\text{MeOH, nm}): 216 (\\log \\epsilon\\ 3.32). \\text{IR } (\\nu_{\\max}, \\text{film, cm}^{-1}): 3418, 2928, 2854, 1748, 1456, 1319, 1086. \\text{MS: EIMS } m/z\\ 426, 309, 291, 273, 269, 251, 241, 223, 205, 141. \\text{NMR: } {}^{1}\\text{H NMR (500 MHz, CDCl}_3), {}^{13}\\text{C NMR (125 MHz, CDCl}_3). \\text{Derivatives: per-MTPA esters } ({}^{1}\\text{H NMR}). \\text{Biological activities } (\\mu\\text{g/mL}): \\text{BST } LC_{50}\\ 3 \\times 10^{-1}, \\text{A-549 } ED_{50}\\ 2.8 \\times 10^{-1}, \\text{MCF-7 } ED_{50}\\ 3.9 \\times 10^{-1}, \\text{HT-29 } ED_{50}\\ 1.2, \\text{A-498 } ED_{50}\\ 1.8 \\times 10^{-1}, \\text{PC-3 } ED_{50}\\ 4.1 \\times 10^{-1}, \\text{PACA-2 } ED_{50}\\ 1.3 \\times 10^{-3}. \\text{Source: } \\textit{Goniothalamus giganteus}\\text{, stem bark.}", "attrs": { "latex": "\\text{White amorphous wax. } [\\alpha]_{D}: -9.7^\\circ (c\\ 0.008, \\text{CHCl}_3). \\text{UV } (\\lambda_{\\max}, \\text{MeOH, nm}): 216 (\\log \\epsilon\\ 3.32). \\text{IR } (\\nu_{\\max}, \\text{film, cm}^{-1}): 3418, 2928, 2854, 1748, 1456, 1319, 1086. \\text{MS: EIMS } m/z\\ 426, 309, 291, 273, 269, 251, 241, 223, 205, 141. \\text{NMR: } {}^{1}\\text{H NMR (500 MHz, CDCl}_3), {}^{13}\\text{C NMR (125 MHz, CDCl}_3). \\text{Derivatives: per-MTPA esters } ({}^{1}\\text{H NMR}). \\text{Biological activities } (\\mu\\text{g/mL}): \\text{BST } LC_{50}\\ 3 \\times 10^{-1}, \\text{A-549 } ED_{50}\\ 2.8 \\times 10^{-1}, \\text{MCF-7 } ED_{50}\\ 3.9 \\times 10^{-1}, \\text{HT-29 } ED_{50}\\ 1.2, \\text{A-498 } ED_{50}\\ 1.8 \\times 10^{-1}, \\text{PC-3 } ED_{50}\\ 4.1 \\times 10^{-1}, \\text{PACA-2 } ED_{50}\\ 1.3 \\times 10^{-3}. \\text{Source: } \\textit{Goniothalamus giganteus}\\text{, stem bark.}", "inline": true, "text_offset": 20, "text_span": 10, "bbox_estimated": true, "notation": "latex", "alt": "White amorphous wax. alpha sub D : minus 9.7 to the power of circ of c 0.008, CHCl sub 3 . UV of lambda sub max, MeOH, nm : 216 times log epsilon 3.32 . IR of nu sub max, film, cm to the power of minus 1 : 3418, 2928, 2854, 1748, 1456, 1319, 1086. MS: EIMS m over z 426, 309, 291, 273, 269, 251, 241, 223, 205, 141. NMR: to the power of 1 H NMR of 500 MHz, CDCl sub 3, to the power of 13 C NMR of 125 MHz, CDCl sub 3 . Derivatives: per minus MTPA esters of to the power of 1 H NMR . Biological activities of mu g over mL : BST LC sub 50 3 times 10 to the power of minus 1, A minus 549 ED sub 50 2.8 times 10 to the power of minus 1, MCF minus 7 ED sub 50 3.9 times 10 to the power of minus 1, HT minus 29 ED sub 50 1.2, A minus 498 ED sub 50 1.8 times 10 to the power of minus 1, PC minus 3 ED sub 50 4.1 times 10 to the power of minus 1, PACA minus 2 ED sub 50 1.3 times 10 to the power of minus 3 . Source: textit Goniothalamus giganteus, stem bark.", "mathml": "White amorphous wax. [α]D:−9.7∘(c 0.008,CHCl3).UV (λmax,MeOH, nm):216(logϵ 3.32).IR (νmax,film, cm−1):3418,2928,2854,1748,1456,1319,1086.MS: EIMS m/z 426,309,291,273,269,251,241,223,205,141.NMR: 1H NMR (500 MHz, CDCl3),13C NMR (125 MHz, CDCl3).Derivatives: per-MTPA esters (1H NMR).Biological activities (μg/mL):BST LC50 3×10−1,A-549 ED50 2.8×10−1,MCF-7 ED50 3.9×10−1,HT-29 ED50 1.2,A-498 ED50 1.8×10−1,PC-3 ED50 4.1×10−1,PACA-2 ED50 1.3×10−3.Source: Goniothalamus giganteus, stem bark." } }, { "id": "p35.19.2", "order": 72, "type": "text", "bbox": { "l": 71.04, "t": 81.12, "r": 531.84, "b": 35.76 }, "text": "\\lambda_{max}", "attrs": { "inline": true, "text_offset": 63, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.19.3", "order": 73, "type": "text", "bbox": { "l": 71.04, "t": 81.12, "r": 531.84, "b": 35.76 }, "text": "\\log \\epsilon", "attrs": { "inline": true, "text_offset": 91, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.19.4", "order": 74, "type": "text", "bbox": { "l": 71.04, "t": 81.12, "r": 531.84, "b": 35.76 }, "text": "\\nu_{max}", "attrs": { "inline": true, "text_offset": 113, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.19.5", "order": 75, "type": "text", "bbox": { "l": 71.04, "t": 81.12, "r": 531.84, "b": 35.76 }, "text": "¹", "attrs": { "inline": true, "text_offset": 251, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.19.6", "order": 76, "type": "text", "bbox": { "l": 71.04, "t": 81.12, "r": 531.84, "b": 35.76 }, "text": "¹³", "attrs": { "inline": true, "text_offset": 288, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.19.7", "order": 77, "type": "text", "bbox": { "l": 71.04, "t": 81.12, "r": 531.84, "b": 35.76 }, "text": "¹", "attrs": { "inline": true, "text_offset": 356, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.19.8", "order": 78, "type": "text", "bbox": { "l": 71.04, "t": 81.12, "r": 531.84, "b": 35.76 }, "text": "μ", "attrs": { "inline": true, "text_offset": 398, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.19.9", "order": 79, "type": "text", "bbox": { "l": 71.04, "t": 81.12, "r": 531.84, "b": 35.76 }, "text": "×", "attrs": { "inline": true, "text_offset": 428, "text_span": 10, "bbox_estimated": true } }, { "id": "p35.19.10", "order": 80, "type": "text", "bbox": { "l": 71.04, "t": 81.12, "r": 531.84, "b": 35.76 }, "text": "×", "attrs": { "inline": true, "text_offset": 465, "text_span": 11, "bbox_estimated": true } }, { "id": "p35.19.11", "order": 81, "type": "text", "bbox": { "l": 71.04, "t": 81.12, "r": 531.84, "b": 35.76 }, "text": "×", "attrs": { "inline": true, "text_offset": 503, "text_span": 11, "bbox_estimated": true } }, { "id": "p35.19.12", "order": 82, "type": "text", "bbox": { "l": 71.04, "t": 81.12, "r": 531.84, "b": 35.76 }, "text": "×", "attrs": { "inline": true, "text_offset": 560, "text_span": 11, "bbox_estimated": true } }, { "id": "p35.19.13", "order": 83, "type": "text", "bbox": { "l": 71.04, "t": 81.12, "r": 531.84, "b": 35.76 }, "text": "×", "attrs": { "inline": true, "text_offset": 597, "text_span": 11, "bbox_estimated": true } }, { "id": "p35.19.14", "order": 84, "type": "text", "bbox": { "l": 71.04, "t": 81.12, "r": 531.84, "b": 35.76 }, "text": "×", "attrs": { "inline": true, "text_offset": 636, "text_span": 11, "bbox_estimated": true } } ] } ], "excluded_furniture": { "first": [], "last": [] } }