{ "document_id": 14408, "page": 27, "width_pt": 612, "height_pt": 792, "rotation": 0, "pipeline_version": "paddleocr-vl-1.6+paul-48", "engine": "paddleocr_vl", "source_run_id": 14519, "item_count": 215, "counts_by_type": { "formula": 23, "header": 3, "heading": 1, "table": 4, "table_cell": 96, "text": 88 }, "build_ms": 28, "items": [ { "id": "p27.1", "order": 1, "type": "header", "bbox": { "l": 53.52, "t": 765.6, "r": 70.8, "b": 756.96 }, "text": "530", "attrs": { "block_label": "number" }, "level": 2 }, { "id": "p27.2", "order": 2, "type": "header", "bbox": { "l": 75.6, "t": 766.08, "r": 264.24, "b": 756.24 }, "text": "Journal of Natural Products, 1999, Vol. 62, No. 3", "attrs": { "block_label": "header" }, "level": 2 }, { "id": "p27.3", "order": 3, "type": "header", "bbox": { "l": 501.36, "t": 766.08, "r": 559.68, "b": 756 }, "text": "Invited Review", "attrs": { "block_label": "header" }, "level": 2 }, { "id": "p27.4", "order": 4, "type": "heading", "bbox": { "l": 53.52, "t": 745.92, "r": 142.8, "b": 736.32 }, "text": "Table 4. (Continued)", "attrs": { "block_label": "paragraph_title" }, "level": 3 }, { "id": "p27.5", "order": 5, "type": "text", "bbox": { "l": 223.68, "t": 734.88, "r": 386.88, "b": 725.04 }, "text": "Adjacent Bis-THF Acetogenins (Continued)" }, { "id": "p27.6", "order": 6, "type": "formula", "bbox": { "l": 150.24, "t": 732.72, "r": 458.88, "b": 609.6 }, "text": "", "attrs": { "block_label": "image", "embedded_text": "H 68 O 8 , MW 638)", "alt": "Bond-line structure of an adjacent bis-THF acetogenin with hydroxyls at C15, C24, C28, C29 and a butenolide ring, with NMR d…", "source": "vision" } }, { "id": "p27.7", "order": 7, "type": "text", "bbox": { "l": 69.84, "t": 720.48, "r": 211.92, "b": 709.92 }, "text": "91. rollitacin[p27.7.1] (C [p27.7.2]H [p27.7.3]O[p27.7.4], MW638)", "children": [ { "id": "p27.7.1", "order": 8, "type": "text", "bbox": { "l": 69.84, "t": 720.48, "r": 211.92, "b": 709.92 }, "text": "¹²¹", "attrs": { "inline": true, "text_offset": 14, "text_span": 9, "bbox_estimated": 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187.28, "b": 634.16 }, "text": "Position", "attrs": { "row": 0, "col": 0, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.8.2", "order": 14, "type": "table_cell", "bbox": { "l": 187.28, "t": 646.08, "r": 221.2, "b": 634.16 }, "text": "15", "attrs": { "row": 0, "col": 1, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.8.3", "order": 15, "type": "table_cell", "bbox": { "l": 221.2, "t": 646.08, "r": 255.12, "b": 634.16 }, "text": "16", "attrs": { "row": 0, "col": 2, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.8.4", "order": 16, "type": "table_cell", "bbox": { "l": 255.12, "t": 646.08, "r": 289.04, "b": 634.16 }, "text": "19", "attrs": { "row": 0, "col": 3, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.8.5", "order": 17, "type": "table_cell", "bbox": { "l": 289.04, "t": 646.08, "r": 322.96, "b": 634.16 }, "text": "20", "attrs": { "row": 0, "col": 4, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.8.6", "order": 18, "type": "table_cell", "bbox": { "l": 322.96, "t": 646.08, "r": 356.88, "b": 634.16 }, "text": "23", "attrs": { "row": 0, "col": 5, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.8.7", "order": 19, "type": "table_cell", "bbox": { "l": 356.88, "t": 646.08, "r": 390.8, "b": 634.16 }, "text": "24", "attrs": { "row": 0, "col": 6, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.8.8", "order": 20, "type": "table_cell", "bbox": { "l": 390.8, "t": 646.08, "r": 424.72, "b": 634.16 }, "text": "28", "attrs": { "row": 0, "col": 7, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.8.9", "order": 21, "type": "table_cell", "bbox": { "l": 424.72, "t": 646.08, "r": 458.64, "b": 634.16 }, "text": "29", "attrs": { "row": 0, "col": 8, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.8.10", "order": 22, "type": "table_cell", "bbox": { "l": 153.36, "t": 634.16, "r": 187.28, "b": 622.24 }, "text": "¹H ( \\delta )", "attrs": { "row": 1, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.11", "order": 23, "type": "table_cell", "bbox": { "l": 187.28, "t": 634.16, "r": 221.2, "b": 622.24 }, "text": "3.40 m", "attrs": { "row": 1, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.12", "order": 24, "type": "table_cell", "bbox": { "l": 221.2, "t": 634.16, "r": 255.12, "b": 622.24 }, "text": "3.86 m", "attrs": { "row": 1, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.13", "order": 25, "type": "table_cell", "bbox": { "l": 255.12, "t": 634.16, "r": 289.04, "b": 622.24 }, "text": "3.86 m", "attrs": { "row": 1, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.14", "order": 26, "type": "table_cell", "bbox": { "l": 289.04, "t": 634.16, "r": 322.96, "b": 622.24 }, "text": "3.93 m", "attrs": { "row": 1, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.15", "order": 27, "type": "table_cell", "bbox": { "l": 322.96, "t": 634.16, "r": 356.88, "b": 622.24 }, "text": "3.93 m", "attrs": { "row": 1, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.16", "order": 28, "type": "table_cell", "bbox": { "l": 356.88, "t": 634.16, "r": 390.8, "b": 622.24 }, "text": "3.86 m", "attrs": { "row": 1, "col": 6, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.17", "order": 29, "type": "table_cell", "bbox": { "l": 390.8, "t": 634.16, "r": 424.72, "b": 622.24 }, "text": "3.60 m", "attrs": { "row": 1, "col": 7, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.18", "order": 30, "type": "table_cell", "bbox": { "l": 424.72, "t": 634.16, "r": 458.64, "b": 622.24 }, "text": "3.60 m", "attrs": { "row": 1, "col": 8, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.19", "order": 31, "type": "table_cell", "bbox": { "l": 153.36, "t": 622.24, "r": 187.28, "b": 610.32 }, "text": "¹³C ( \\delta )", "attrs": { "row": 2, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.20", "order": 32, "type": "table_cell", "bbox": { "l": 187.28, "t": 622.24, "r": 221.2, "b": 610.32 }, "text": "74.2", "attrs": { "row": 2, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.21", "order": 33, "type": "table_cell", "bbox": { "l": 221.2, "t": 622.24, "r": 255.12, "b": 610.32 }, "text": "83.4", "attrs": { "row": 2, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.22", "order": 34, "type": "table_cell", "bbox": { "l": 255.12, "t": 622.24, "r": 289.04, "b": 610.32 }, "text": "82.9", "attrs": { "row": 2, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.23", "order": 35, "type": "table_cell", "bbox": { "l": 289.04, "t": 622.24, "r": 322.96, "b": 610.32 }, "text": "82.6", "attrs": { "row": 2, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.24", "order": 36, "type": "table_cell", "bbox": { "l": 322.96, "t": 622.24, "r": 356.88, "b": 610.32 }, "text": "82.2", "attrs": { "row": 2, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.25", "order": 37, "type": "table_cell", "bbox": { "l": 356.88, "t": 622.24, "r": 390.8, "b": 610.32 }, "text": "71.5", "attrs": { "row": 2, "col": 6, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.26", "order": 38, "type": "table_cell", "bbox": { "l": 390.8, "t": 622.24, "r": 424.72, "b": 610.32 }, "text": "74.6", "attrs": { "row": 2, "col": 7, "rowspan": 1, "colspan": 1 } }, { "id": "p27.8.27", "order": 39, "type": "table_cell", "bbox": { "l": 424.72, "t": 622.24, "r": 458.64, "b": 610.32 }, "text": "74.7", "attrs": { "row": 2, "col": 8, "rowspan": 1, "colspan": 1 } } ] }, { "id": "p27.9", "order": 40, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "White waxy solid.[p27.9.1]: +15.7° (c O62, CHCl_{3}). UV ([p27.9.2], MeOH, nm): 222 ([p27.9.3] 3.54). IR ([p27.9.4], film, cm^{-1}): 3348, 2924, 1743, 1668, 1071. MS: EIMS (TMS) m/z 753, 663, 507, 489, 399, 367, 329, 173. NMR: [p27.9.5]H NMR (500 MHz, CDCl_{3}), [p27.9.6]C NMR (125 MHz, CDCl_{3}). Derivatives: formal acetal ( [p27.9.7]H NMR), TMS (EIMS). Biological activities ( [p27.9.8]g/mL): BST LC[p27.9.9] 4.3 × 10^{-1}, A-549 ED[p27.9.10] 1.6, MCF-7 ED[p27.9.11] 2.5 × 10^{-4}, HT-29 ED[p27.9.12] 4.6 × 10^{-3}, A-498 ED[p27.9.13] 1.5, PC-3 ED[p27.9.14] 1.1, PAC-2 ED[p27.9.15] 3.0. Source: Rollinia mucosa, leaves.", "children": [ { "id": "p27.9.1", "order": 41, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "[\\alpha]_{D}", "attrs": { "inline": true, "text_offset": 17, "text_span": 9, "bbox_estimated": true } }, { "id": "p27.9.2", "order": 42, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "\\lambda_{max}", "attrs": { "inline": true, "text_offset": 58, "text_span": 9, "bbox_estimated": true } }, { "id": "p27.9.3", "order": 43, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "\\log \\epsilon", "attrs": { "inline": true, "text_offset": 85, "text_span": 9, "bbox_estimated": true } }, { "id": "p27.9.4", "order": 44, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "\\nu_{max}", "attrs": { "inline": true, "text_offset": 106, "text_span": 9, "bbox_estimated": true } }, { "id": "p27.9.5", "order": 45, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "¹", "attrs": { "inline": true, "text_offset": 227, "text_span": 9, "bbox_estimated": true } }, { "id": "p27.9.6", "order": 46, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "¹³", "attrs": { "inline": true, "text_offset": 263, "text_span": 9, "bbox_estimated": true } }, { "id": "p27.9.7", "order": 47, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "¹", "attrs": { "inline": true, "text_offset": 328, "text_span": 9, "bbox_estimated": true } }, { "id": "p27.9.8", "order": 48, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "μ", "attrs": { "inline": true, "text_offset": 381, "text_span": 9, "bbox_estimated": true } }, { "id": "p27.9.9", "order": 49, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 403, "text_span": 9, "bbox_estimated": true } }, { "id": "p27.9.10", "order": 50, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 436, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.9.11", "order": 51, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 460, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.9.12", "order": 52, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 494, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.9.13", "order": 53, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 528, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.9.14", "order": 54, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 551, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.9.15", "order": 55, "type": "text", "bbox": { "l": 71.28, "t": 604.56, "r": 495.84, "b": 557.28 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 575, "text_span": 10, "bbox_estimated": true } } ] }, { "id": "p27.10", "order": 56, "type": "text", "bbox": { "l": 70.56, "t": 554.88, "r": 215.28, "b": 543.84 }, "text": "92. rollinacin[p27.10.1] (C [p27.10.2]H [p27.10.3]O[p27.10.4], MW594)", "children": [ { "id": "p27.10.1", "order": 57, "type": "text", "bbox": { "l": 70.56, "t": 554.88, "r": 215.28, "b": 543.84 }, "text": "¹²¹", "attrs": { "inline": true, "text_offset": 14, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.10.2", "order": 58, "type": "text", "bbox": { "l": 70.56, "t": 554.88, "r": 215.28, "b": 543.84 }, "text": "₃₅", "attrs": { "inline": true, "text_offset": 28, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.10.3", "order": 59, "type": "text", "bbox": { "l": 70.56, "t": 554.88, "r": 215.28, "b": 543.84 }, "text": "₆₂", "attrs": { "inline": true, "text_offset": 40, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.10.4", "order": 60, "type": "text", "bbox": { "l": 70.56, "t": 554.88, "r": 215.28, "b": 543.84 }, "text": "₇", "attrs": { "inline": true, "text_offset": 51, "text_span": 10, "bbox_estimated": true } } ] }, { "id": "p27.11", "order": 61, "type": "formula", "bbox": { "l": 158.88, "t": 539.52, "r": 450.48, "b": 442.8 }, "text": "", "attrs": { "block_label": "image", "alt": "Bond-line structure of an acetogenin-type annonaceous compound with two tetrahydrofuran rings, hydroxyls at C4, C10, C15 and…", "source": "vision" } }, { "id": "p27.12", "order": 62, "type": "table", "bbox": { "l": 159.84, "t": 480.96, "r": 395.76, "b": 444.96 }, "text": "", "attrs": { "block_label": "table", "n_rows": 3, "n_cols": 7, "integrity": { "skipped": "no_text_layer" } }, "children": [ { "id": "p27.12.1", "order": 63, "type": "table_cell", "bbox": { "l": 159.84, "t": 480.96, "r": 193.5429, "b": 468.96 }, "text": "Position", "attrs": { "row": 0, "col": 0, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.12.2", "order": 64, "type": "table_cell", "bbox": { "l": 193.5429, "t": 480.96, "r": 227.2457, "b": 468.96 }, "text": "10", "attrs": { "row": 0, "col": 1, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.12.3", "order": 65, "type": "table_cell", "bbox": { "l": 227.2457, "t": 480.96, "r": 260.9486, "b": 468.96 }, "text": "12", "attrs": { "row": 0, "col": 2, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.12.4", "order": 66, "type": "table_cell", "bbox": { "l": 260.9486, "t": 480.96, "r": 294.6514, "b": 468.96 }, "text": "15", "attrs": { "row": 0, "col": 3, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.12.5", "order": 67, "type": "table_cell", "bbox": { "l": 294.6514, "t": 480.96, "r": 328.3543, "b": 468.96 }, "text": "16", "attrs": { "row": 0, "col": 4, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.12.6", "order": 68, "type": "table_cell", "bbox": { "l": 328.3543, "t": 480.96, "r": 362.0571, "b": 468.96 }, "text": "19", "attrs": { "row": 0, "col": 5, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.12.7", "order": 69, "type": "table_cell", "bbox": { "l": 362.0571, "t": 480.96, "r": 395.76, "b": 468.96 }, "text": "20", "attrs": { "row": 0, "col": 6, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.12.8", "order": 70, "type": "table_cell", "bbox": { "l": 159.84, "t": 468.96, "r": 193.5429, "b": 456.96 }, "text": "¹H ( δ)", "attrs": { "row": 1, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p27.12.9", "order": 71, "type": "table_cell", "bbox": { "l": 193.5429, "t": 468.96, "r": 227.2457, "b": 456.96 }, "text": "3.82 m", "attrs": { "row": 1, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p27.12.10", "order": 72, "type": "table_cell", "bbox": { "l": 227.2457, "t": 468.96, "r": 260.9486, "b": 456.96 }, "text": "4.22 m", "attrs": { "row": 1, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p27.12.11", "order": 73, "type": "table_cell", "bbox": { "l": 260.9486, "t": 468.96, "r": 294.6514, "b": 456.96 }, "text": "3.97 m", "attrs": { "row": 1, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p27.12.12", "order": 74, "type": "table_cell", "bbox": { "l": 294.6514, "t": 468.96, "r": 328.3543, "b": 456.96 }, "text": "3.92 m", "attrs": { "row": 1, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p27.12.13", "order": 75, "type": "table_cell", "bbox": { "l": 328.3543, "t": 468.96, "r": 362.0571, "b": 456.96 }, "text": "3.83 m", "attrs": { "row": 1, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p27.12.14", "order": 76, "type": "table_cell", "bbox": { "l": 362.0571, "t": 468.96, "r": 395.76, "b": 456.96 }, "text": "3.38 m", "attrs": { "row": 1, "col": 6, "rowspan": 1, "colspan": 1 } }, { "id": "p27.12.15", "order": 77, "type": "table_cell", "bbox": { "l": 159.84, "t": 456.96, "r": 193.5429, "b": 444.96 }, "text": "¹³C ( δ)", "attrs": { "row": 2, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p27.12.16", "order": 78, "type": "table_cell", "bbox": { "l": 193.5429, "t": 456.96, "r": 227.2457, "b": 444.96 }, "text": "71.7", "attrs": { "row": 2, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p27.12.17", "order": 79, "type": "table_cell", "bbox": { "l": 227.2457, "t": 456.96, "r": 260.9486, "b": 444.96 }, "text": "80.5", "attrs": { "row": 2, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p27.12.18", "order": 80, "type": "table_cell", "bbox": { "l": 260.9486, "t": 456.96, "r": 294.6514, "b": 444.96 }, "text": "80.9", "attrs": { "row": 2, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p27.12.19", "order": 81, "type": "table_cell", "bbox": { "l": 294.6514, "t": 456.96, "r": 328.3543, "b": 444.96 }, "text": "81.0", "attrs": { "row": 2, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p27.12.20", "order": 82, "type": "table_cell", "bbox": { "l": 328.3543, "t": 456.96, "r": 362.0571, "b": 444.96 }, "text": "82.8", "attrs": { "row": 2, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p27.12.21", "order": 83, "type": "table_cell", "bbox": { "l": 362.0571, "t": 456.96, "r": 395.76, "b": 444.96 }, "text": "74.4", "attrs": { "row": 2, "col": 6, "rowspan": 1, "colspan": 1 } } ] }, { "id": "p27.13", "order": 84, "type": "text", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "Oil. UV ([p27.13.1], MeOH, nm): 222 ([p27.13.2] 3.52). IR ([p27.13.3], film, cm[p27.13.4]): 3446, 2938. 1731, 1670, 1079. MS: EIMS m/z 395, 377, 365, 325, 307, 289, 269, 241, 223, 205, 199, 181, 141, 123. NMR: [p27.13.5]H NMR (500MHz, CDCl[p27.13.6]), [p27.13.7]C NMR (125MHz, CDCl[p27.13.8]). Derivatives: formal acetal ( [p27.13.9]H NMR), TMS (EIMS). Biological activities ( [p27.13.10]g/mL): BST LC[p27.13.11] 3.5, A-549ED[p27.13.12] 4.6[p27.13.13] 10[p27.13.14], MCF-7ED[p27.13.15] 1.6[p27.13.16] 10[p27.13.17], HT-29ED[p27.13.18] 2.1, A-498ED[p27.13.19] 1.6, PC-3ED[p27.13.20] 2.5, PAC-2ED[p27.13.21] 2.0. Source: Rollinia mucosa, leaves.", "children": [ { "id": "p27.13.1", "order": 85, "type": "text", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "\\lambda_{max}", "attrs": { "inline": true, "text_offset": 9, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.13.2", "order": 86, "type": "text", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "log ε", "attrs": { "inline": true, "text_offset": 37, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.13.3", "order": 87, "type": "text", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "\\nu_{max}", "attrs": { "inline": true, "text_offset": 59, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.13.4", "order": 88, "type": "text", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "⁻¹", "attrs": { "inline": true, "text_offset": 79, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.13.5", "order": 89, "type": "formula", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "¹", "attrs": { "latex": "^{1}", "inline": true, "text_offset": 210, "text_span": 10, "bbox_estimated": true, "alt": "to the power of 1", "mathml": "1" } }, { "id": "p27.13.6", "order": 90, "type": "text", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "₃", "attrs": { "inline": true, "text_offset": 239, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.13.7", "order": 91, "type": "text", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "¹³", "attrs": { "inline": true, "text_offset": 252, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.13.8", "order": 92, "type": "text", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "₃", "attrs": { "inline": true, "text_offset": 281, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.13.9", "order": 93, "type": "formula", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "¹", "attrs": { "latex": "^{1}", "inline": true, "text_offset": 323, "text_span": 10, "bbox_estimated": true, "alt": "to the power of 1", "mathml": "1" } }, { "id": "p27.13.10", "order": 94, "type": "text", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "μ", "attrs": { "inline": true, "text_offset": 377, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.13.11", "order": 95, "type": "formula", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "₅₀", "attrs": { "latex": "_{50}", "inline": true, "text_offset": 401, "text_span": 11, "bbox_estimated": true, "alt": "sub 50", "mathml": "50" } }, { "id": "p27.13.12", "order": 96, "type": "formula", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "₅₀", "attrs": { "latex": "_{50}", "inline": true, "text_offset": 425, "text_span": 11, "bbox_estimated": true, "alt": "sub 50", "mathml": "50" } }, { "id": "p27.13.13", "order": 97, "type": "formula", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "\\text{Oil. UV } (\\lambda_{\\max}, \\text{MeOH, nm}): 222\\ (\\log \\epsilon\\ 3.52). \\text{IR } (\\nu_{\\max}, \\text{film, cm}^{-1}): 3446, 2938, 1731, 1670, 1079. \\text{MS: EIMS } m/z\\ 395, 377, 365, 325, 307, 289, 269, 241, 223, 205, 199, 181, 141, 123. \\text{NMR: } {}^{1}\\text{H NMR (500 MHz, CDCl}_3), {}^{13}\\text{C NMR } (125 \\text{ MHz, CDCl}_3). \\text{Derivatives: formal acetal } ({}^{1}\\text{H NMR}), \\text{TMS (EIMS). Biological activities } (\\mu\\text{g/mL}): \\text{BST LC}_{50}\\ 3.5, \\text{A-549 ED}_{50}\\ 4.6 \\times 10^{-2}, \\text{MCF-7 ED}_{50}\\ 1.6 \\times 10^{-1}, \\text{HT-29 ED}_{50}\\ 2.1, \\text{A-498 ED}_{50}\\ 1.6, \\text{PC-3 ED}_{50}\\ 2.5, \\text{PACA-2 ED}_{50}\\ 2.0. \\text{Source: } \\textit{Rollinia mucosa}, \\text{leaves.}", "attrs": { "latex": "\\text{Oil. UV } (\\lambda_{\\max}, \\text{MeOH, nm}): 222\\ (\\log \\epsilon\\ 3.52). \\text{IR } (\\nu_{\\max}, \\text{film, cm}^{-1}): 3446, 2938, 1731, 1670, 1079. \\text{MS: EIMS } m/z\\ 395, 377, 365, 325, 307, 289, 269, 241, 223, 205, 199, 181, 141, 123. \\text{NMR: } {}^{1}\\text{H NMR (500 MHz, CDCl}_3), {}^{13}\\text{C NMR } (125 \\text{ MHz, CDCl}_3). \\text{Derivatives: formal acetal } ({}^{1}\\text{H NMR}), \\text{TMS (EIMS). Biological activities } (\\mu\\text{g/mL}): \\text{BST LC}_{50}\\ 3.5, \\text{A-549 ED}_{50}\\ 4.6 \\times 10^{-2}, \\text{MCF-7 ED}_{50}\\ 1.6 \\times 10^{-1}, \\text{HT-29 ED}_{50}\\ 2.1, \\text{A-498 ED}_{50}\\ 1.6, \\text{PC-3 ED}_{50}\\ 2.5, \\text{PACA-2 ED}_{50}\\ 2.0. \\text{Source: } \\textit{Rollinia mucosa}, \\text{leaves.}", "inline": true, "text_offset": 440, "text_span": 11, "bbox_estimated": true, "alt": "Oil. UV of lambda sub max, MeOH, nm : 222 times log epsilon 3.52 . IR of nu sub max, film, cm to the power of minus 1 : 3446, 2938, 1731, 1670, 1079. MS: EIMS m over z 395, 377, 365, 325, 307, 289, 269, 241, 223, 205, 199, 181, 141, 123. NMR: to the power of 1 H NMR of 500 MHz, CDCl sub 3, to the power of 13 C NMR of 125 MHz, CDCl sub 3 . Derivatives: formal acetal of to the power of 1 H NMR, TMS of EIMS . Biological activities of mu g over mL : BST LC sub 50 3.5, A minus 549 ED sub 50 4.6 times 10 to the power of minus 2, MCF minus 7 ED sub 50 1.6 times 10 to the power of minus 1, HT minus 29 ED sub 50 2.1, A minus 498 ED sub 50 1.6, PC minus 3 ED sub 50 2.5, PACA minus 2 ED sub 50 2.0. Source: textit Rollinia mucosa, leaves.", "notation": "latex", "mathml": "Oil. UV (λmax,MeOH, nm):222 (logϵ 3.52).IR (νmax,film, cm−1):3446,2938,1731,1670,1079.MS: EIMS m/z 395,377,365,325,307,289,269,241,223,205,199,181,141,123.NMR: 1H NMR (500 MHz, CDCl3),13C NMR (125 MHz, CDCl3).Derivatives: formal acetal (1H NMR),TMS (EIMS). Biological activities (μg/mL):BST LC50 3.5,A-549 ED50 4.6×10−2,MCF-7 ED50 1.6×10−1,HT-29 ED50 2.1,A-498 ED50 1.6,PC-3 ED50 2.5,PACA-2 ED50 2.0.Source: Rollinia mucosa,leaves." } }, { "id": "p27.13.14", "order": 98, "type": "text", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "⁻²", "attrs": { "inline": true, "text_offset": 454, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.13.15", "order": 99, "type": "formula", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "₅₀", "attrs": { "latex": "_{50}", "inline": true, "text_offset": 474, "text_span": 11, "bbox_estimated": true, "alt": "sub 50", "mathml": "50" } }, { "id": "p27.13.16", "order": 100, "type": "formula", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "\\text{Oil. UV } (\\lambda_{\\max}, \\text{MeOH, nm}): 222\\ (\\log \\epsilon\\ 3.52). \\text{IR } (\\nu_{\\max}, \\text{film, cm}^{-1}): 3446, 2938, 1731, 1670, 1079. \\text{MS: EIMS } m/z\\ 395, 377, 365, 325, 307, 289, 269, 241, 223, 205, 199, 181, 141, 123. \\text{NMR: } {}^{1}\\text{H NMR (500 MHz, CDCl}_3), {}^{13}\\text{C NMR } (125 \\text{ MHz, CDCl}_3). \\text{Derivatives: formal acetal } ({}^{1}\\text{H NMR}), \\text{TMS (EIMS). Biological activities } (\\mu\\text{g/mL}): \\text{BST LC}_{50}\\ 3.5, \\text{A-549 ED}_{50}\\ 4.6 \\times 10^{-2}, \\text{MCF-7 ED}_{50}\\ 1.6 \\times 10^{-1}, \\text{HT-29 ED}_{50}\\ 2.1, \\text{A-498 ED}_{50}\\ 1.6, \\text{PC-3 ED}_{50}\\ 2.5, \\text{PACA-2 ED}_{50}\\ 2.0. \\text{Source: } \\textit{Rollinia mucosa}, \\text{leaves.}", "attrs": { "latex": "\\text{Oil. UV } (\\lambda_{\\max}, \\text{MeOH, nm}): 222\\ (\\log \\epsilon\\ 3.52). \\text{IR } (\\nu_{\\max}, \\text{film, cm}^{-1}): 3446, 2938, 1731, 1670, 1079. \\text{MS: EIMS } m/z\\ 395, 377, 365, 325, 307, 289, 269, 241, 223, 205, 199, 181, 141, 123. \\text{NMR: } {}^{1}\\text{H NMR (500 MHz, CDCl}_3), {}^{13}\\text{C NMR } (125 \\text{ MHz, CDCl}_3). \\text{Derivatives: formal acetal } ({}^{1}\\text{H NMR}), \\text{TMS (EIMS). Biological activities } (\\mu\\text{g/mL}): \\text{BST LC}_{50}\\ 3.5, \\text{A-549 ED}_{50}\\ 4.6 \\times 10^{-2}, \\text{MCF-7 ED}_{50}\\ 1.6 \\times 10^{-1}, \\text{HT-29 ED}_{50}\\ 2.1, \\text{A-498 ED}_{50}\\ 1.6, \\text{PC-3 ED}_{50}\\ 2.5, \\text{PACA-2 ED}_{50}\\ 2.0. \\text{Source: } \\textit{Rollinia mucosa}, \\text{leaves.}", "inline": true, "text_offset": 489, "text_span": 11, "bbox_estimated": true, "alt": "Oil. UV of lambda sub max, MeOH, nm : 222 times log epsilon 3.52 . IR of nu sub max, film, cm to the power of minus 1 : 3446, 2938, 1731, 1670, 1079. MS: EIMS m over z 395, 377, 365, 325, 307, 289, 269, 241, 223, 205, 199, 181, 141, 123. NMR: to the power of 1 H NMR of 500 MHz, CDCl sub 3, to the power of 13 C NMR of 125 MHz, CDCl sub 3 . Derivatives: formal acetal of to the power of 1 H NMR, TMS of EIMS . Biological activities of mu g over mL : BST LC sub 50 3.5, A minus 549 ED sub 50 4.6 times 10 to the power of minus 2, MCF minus 7 ED sub 50 1.6 times 10 to the power of minus 1, HT minus 29 ED sub 50 2.1, A minus 498 ED sub 50 1.6, PC minus 3 ED sub 50 2.5, PACA minus 2 ED sub 50 2.0. Source: textit Rollinia mucosa, leaves.", "notation": "latex", "mathml": "Oil. UV (λmax,MeOH, nm):222 (logϵ 3.52).IR (νmax,film, cm−1):3446,2938,1731,1670,1079.MS: EIMS m/z 395,377,365,325,307,289,269,241,223,205,199,181,141,123.NMR: 1H NMR (500 MHz, CDCl3),13C NMR (125 MHz, CDCl3).Derivatives: formal acetal (1H NMR),TMS (EIMS). Biological activities (μg/mL):BST LC50 3.5,A-549 ED50 4.6×10−2,MCF-7 ED50 1.6×10−1,HT-29 ED50 2.1,A-498 ED50 1.6,PC-3 ED50 2.5,PACA-2 ED50 2.0.Source: Rollinia mucosa,leaves." } }, { "id": "p27.13.17", "order": 101, "type": "text", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "⁻¹", "attrs": { "inline": true, "text_offset": 503, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.13.18", "order": 102, "type": "formula", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "₅₀", "attrs": { "latex": "_{50}", "inline": true, "text_offset": 523, "text_span": 11, "bbox_estimated": true, "alt": "sub 50", "mathml": "50" } }, { "id": "p27.13.19", "order": 103, "type": "formula", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "₅₀", "attrs": { "latex": "_{50}", "inline": true, "text_offset": 547, "text_span": 11, "bbox_estimated": true, "alt": "sub 50", "mathml": "50" } }, { "id": "p27.13.20", "order": 104, "type": "formula", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "₅₀", "attrs": { "latex": "_{50}", "inline": true, "text_offset": 570, "text_span": 11, "bbox_estimated": true, "alt": "sub 50", "mathml": "50" } }, { "id": "p27.13.21", "order": 105, "type": "formula", "bbox": { "l": 71.04, "t": 439.68, "r": 498, "b": 393.12 }, "text": "₅₀", "attrs": { "latex": "_{50}", "inline": true, "text_offset": 594, "text_span": 11, "bbox_estimated": true, "alt": "sub 50", "mathml": "50" } } ] }, { "id": "p27.14", "order": 106, "type": "text", "bbox": { "l": 70.56, "t": 389.28, "r": 218.88, "b": 378.48 }, "text": "93. glabracin A [p27.14.1](C [p27.14.2]H [p27.14.3]O[p27.14.4], MW638)", "children": [ { "id": "p27.14.1", "order": 107, "type": "formula", "bbox": { "l": 70.56, "t": 389.28, "r": 218.88, "b": 378.48 }, "text": "\\textbf{93. glabracin A}^{24} \\text{ (C}_{37}\\text{H}_{68}\\text{O}_{7}\\text{, MW 638)}", "attrs": { "latex": "\\textbf{93. glabracin A}^{24} \\text{ (C}_{37}\\text{H}_{68}\\text{O}_{7}\\text{, MW 638)}", "inline": true, "text_offset": 16, "text_span": 10, "bbox_estimated": true, "alt": "textbf 93. glabracin A to the power of 24 times C sub 37 H sub 68 O sub 7, MW 638", "notation": "latex", "mathml": "93. glabracin A24 (C37H68O7, MW 638)" } }, { "id": "p27.14.2", "order": 108, "type": "formula", "bbox": { "l": 70.56, "t": 389.28, "r": 218.88, "b": 378.48 }, "text": "\\textbf{93. glabracin A}^{24} \\, (\\mathrm{C}_{37}\\mathrm{H}_{68}\\mathrm{O}_{7}, \\mathrm{MW}\\,638)", "attrs": { "latex": "\\textbf{93. glabracin A}^{24} \\, (\\mathrm{C}_{37}\\mathrm{H}_{68}\\mathrm{O}_{7}, \\mathrm{MW}\\,638)", "inline": true, "text_offset": 29, "text_span": 10, "bbox_estimated": true, "alt": "textbf 93. glabracin A to the power of 24, C sub 37 H sub 68 O sub 7, MW, 638", "notation": "latex", "mathml": "93. glabracin A24(C37H68O7,MW638)" } }, { "id": "p27.14.3", "order": 109, "type": "formula", "bbox": { "l": 70.56, "t": 389.28, "r": 218.88, "b": 378.48 }, "text": "\\textbf{93. glabracin A}^{24} \\, (\\mathrm{C}_{37}\\mathrm{H}_{68}\\mathrm{O}_{7}, \\mathrm{MW}\\,638)", "attrs": { "latex": "\\textbf{93. glabracin A}^{24} \\, (\\mathrm{C}_{37}\\mathrm{H}_{68}\\mathrm{O}_{7}, \\mathrm{MW}\\,638)", "inline": true, "text_offset": 41, "text_span": 10, "bbox_estimated": true, "alt": "textbf 93. glabracin A to the power of 24, C sub 37 H sub 68 O sub 7, MW, 638", "notation": "latex", "mathml": "93. glabracin A24(C37H68O7,MW638)" } }, { "id": "p27.14.4", "order": 110, "type": "formula", "bbox": { "l": 70.56, "t": 389.28, "r": 218.88, "b": 378.48 }, "text": "\\textbf{93. glabracin A}^{24} \\, (\\mathrm{C}_{37}\\mathrm{H}_{68}\\mathrm{O}_{7}, \\mathrm{MW}\\,638)", "attrs": { "latex": "\\textbf{93. glabracin A}^{24} \\, (\\mathrm{C}_{37}\\mathrm{H}_{68}\\mathrm{O}_{7}, \\mathrm{MW}\\,638)", "inline": true, "text_offset": 52, "text_span": 10, "bbox_estimated": true, "alt": "textbf 93. glabracin A to the power of 24, C sub 37 H sub 68 O sub 7, MW, 638", "notation": "latex", "mathml": "93. glabracin A24(C37H68O7,MW638)" } } ] }, { "id": "p27.15", "order": 111, "type": "formula", "bbox": { "l": 153.6, "t": 370.32, "r": 456.96, "b": 274.32 }, "text": "", "attrs": { "block_label": "image", "alt": "Skeletal structure of an annonaceous acetogenin with a butenolide, two bis-tetrahydrofuran rings, and hydroxyls at C4, C10,…", "source": "vision" } }, { "id": "p27.16", "order": 112, "type": "table", "bbox": { "l": 154.8, "t": 311.28, "r": 429.6, "b": 274.56 }, "text": "", "attrs": { "block_label": "table", "n_rows": 3, "n_cols": 8, "integrity": { "skipped": "no_text_layer" } }, "children": [ { "id": "p27.16.1", "order": 113, "type": "table_cell", "bbox": { "l": 154.8, "t": 311.28, "r": 189.15, "b": 299.04 }, "text": "Position", "attrs": { "row": 0, "col": 0, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.16.2", "order": 114, "type": "table_cell", "bbox": { "l": 189.15, "t": 311.28, "r": 223.5, "b": 299.04 }, "text": "10", "attrs": { "row": 0, "col": 1, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.16.3", "order": 115, "type": "table_cell", "bbox": { "l": 223.5, "t": 311.28, "r": 257.85, "b": 299.04 }, "text": "11", "attrs": { "row": 0, "col": 2, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.16.4", "order": 116, "type": "table_cell", "bbox": { "l": 257.85, "t": 311.28, "r": 292.2, "b": 299.04 }, "text": "14", "attrs": { "row": 0, "col": 3, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": 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"heuristic" } }, { "id": "p27.16.9", "order": 121, "type": "table_cell", "bbox": { "l": 154.8, "t": 299.04, "r": 189.15, "b": 286.8 }, "text": "¹H ( δ)", "attrs": { "row": 1, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p27.16.10", "order": 122, "type": "table_cell", "bbox": { "l": 189.15, "t": 299.04, "r": 223.5, "b": 286.8 }, "text": "3.42 m", "attrs": { "row": 1, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p27.16.11", "order": 123, "type": "table_cell", "bbox": { "l": 223.5, "t": 299.04, "r": 257.85, "b": 286.8 }, "text": "3.80 m", "attrs": { "row": 1, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p27.16.12", "order": 124, "type": "table_cell", "bbox": { "l": 257.85, "t": 299.04, "r": 292.2, "b": 286.8 }, "text": "3.80 m", "attrs": { "row": 1, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p27.16.13", "order": 125, "type": "table_cell", "bbox": { "l": 292.2, "t": 299.04, "r": 326.55, "b": 286.8 }, "text": "3.80 m", "attrs": { "row": 1, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p27.16.14", "order": 126, "type": "table_cell", "bbox": { "l": 326.55, "t": 299.04, "r": 360.9, "b": 286.8 }, "text": "3.80 m", "attrs": { "row": 1, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p27.16.15", "order": 127, "type": "table_cell", "bbox": { "l": 360.9, "t": 299.04, "r": 395.25, "b": 286.8 }, "text": "3.61 m", "attrs": { "row": 1, "col": 6, "rowspan": 1, "colspan": 1 } }, { "id": "p27.16.16", "order": 128, "type": "table_cell", "bbox": { "l": 395.25, "t": 299.04, "r": 429.6, "b": 286.8 }, "text": "3.61 m", "attrs": { "row": 1, "col": 7, "rowspan": 1, "colspan": 1 } }, { "id": "p27.16.17", "order": 129, "type": "table_cell", "bbox": { "l": 154.8, "t": 286.8, "r": 189.15, "b": 274.56 }, "text": "¹³C ( δ)", "attrs": { "row": 2, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p27.16.18", "order": 130, "type": "table_cell", "bbox": { "l": 189.15, "t": 286.8, "r": 223.5, "b": 274.56 }, "text": "74.13", "attrs": { "row": 2, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p27.16.19", "order": 131, "type": "table_cell", "bbox": { "l": 223.5, "t": 286.8, "r": 257.85, "b": 274.56 }, "text": "82.65", "attrs": { "row": 2, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p27.16.20", "order": 132, "type": "table_cell", "bbox": { "l": 257.85, "t": 286.8, "r": 292.2, "b": 274.56 }, "text": "82.07", "attrs": { "row": 2, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p27.16.21", "order": 133, "type": "table_cell", "bbox": { "l": 292.2, "t": 286.8, "r": 326.55, "b": 274.56 }, "text": "82.30", "attrs": { "row": 2, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p27.16.22", "order": 134, "type": "table_cell", "bbox": { "l": 326.55, "t": 286.8, "r": 360.9, "b": 274.56 }, "text": "79.89", "attrs": { "row": 2, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p27.16.23", "order": 135, "type": "table_cell", "bbox": { "l": 360.9, "t": 286.8, "r": 395.25, "b": 274.56 }, "text": "74.48", "attrs": { "row": 2, "col": 6, "rowspan": 1, "colspan": 1 } }, { "id": "p27.16.24", "order": 136, "type": "table_cell", "bbox": { "l": 395.25, "t": 286.8, "r": 429.6, "b": 274.56 }, "text": "74.71", "attrs": { "row": 2, "col": 7, "rowspan": 1, "colspan": 1 } } ] }, { "id": "p27.17", "order": 137, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "White wax solid.[p27.17.1]: -11.6° (c QOI3, CHCl3). UV ([p27.17.2], MeOH, nm): 220 (log[p27.17.3] 3.89). IR ([p27.17.4], film, cm[p27.17.5]): 3330, 2919, 2850, 1747, 1717, 1469, 1320, 1203, 1064, 956, 758 MS: EIMS m/z 467, 449, 431, 413, 397, 379, 361, 327, 311, 309, 293, 291, 275, 241, 223, 205, 171, 141. NMR: [p27.17.6]H NMR (500MHz, CDCl[p27.17.7]), [p27.17.8]C NMR (125MHz, CDCl[p27.17.9]). Derivatives: per-MTPA esters ( [p27.17.10]H NMR). Biological activities ( [p27.17.11]g/mL): BST LC[p27.17.12] 1.3[p27.17.13] 10[p27.17.14], A-549 ED[p27.17.15] 2.8[p27.17.16] 10[p27.17.17], MCF-7 ED[p27.17.18] 4.2[p27.17.19] 10[p27.17.20], HT-29 ED[p27.17.21] 5.7[p27.17.22] 10[p27.17.23], A-498 ED[p27.17.24] 1.0, PC-3 ED[p27.17.25] 1.1, PAC-2 ED[p27.17.26] 1.8. Source: Annona glabra, leaves.", "children": [ { "id": "p27.17.1", "order": 138, "type": "formula", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "[\\alpha]_{D}: -11.6^\\circ (c\\,0.013, \\mathrm{CHCl_3}), \\text{UV} (\\lambda_{\\max}, \\mathrm{MeOH}, \\text{nm}): 220 (\\log \\epsilon\\, 3.89), \\text{IR} (\\nu_{\\max}, \\text{film}, \\text{cm}^{-1}): 3330, 2919, 2850, 1747, 1717, 1469, 1320, 1203, 1064, 956, 758. \\text{MS: EIMS } m/z\\ 467, 449, 431, 413, 397, 379, 361, 327, 311, 309, 293, 291, 275, 241, 223, 205, 171, 141. \\text{NMR: } {}^{1}\\mathrm{H NMR (500 MHz, CDCl_3)}, {}^{13}\\mathrm{C NMR (125 MHz, CDCl_3)}. \\text{Derivatives: per-MTPA esters } ({}^{1}\\mathrm{H NMR}). \\text{Biological activities } (\\mu g/mL): \\text{BST } LC_{50}\\ 1.3\\times10^{-1}, \\text{A-549 } ED_{50}\\ 2.8\\times10^{-6}, \\text{MCF-7 } ED_{50}\\ 4.2\\times10^{-6}, \\text{HT-29 } ED_{50}\\ 5.7\\times10^{-6}, \\text{A-498 } ED_{50}\\ 1.0, \\text{PC-3 } ED_{50}\\ 1.1, \\text{PACA-2 } ED_{50}\\ 1.8. \\text{Source: } \\textit{Annona glabra}, \\text{leaves.}", "attrs": { "latex": "[\\alpha]_{D}: -11.6^\\circ (c\\,0.013, \\mathrm{CHCl_3}), \\text{UV} (\\lambda_{\\max}, \\mathrm{MeOH}, \\text{nm}): 220 (\\log \\epsilon\\, 3.89), \\text{IR} (\\nu_{\\max}, \\text{film}, \\text{cm}^{-1}): 3330, 2919, 2850, 1747, 1717, 1469, 1320, 1203, 1064, 956, 758. \\text{MS: EIMS } m/z\\ 467, 449, 431, 413, 397, 379, 361, 327, 311, 309, 293, 291, 275, 241, 223, 205, 171, 141. \\text{NMR: } {}^{1}\\mathrm{H NMR (500 MHz, CDCl_3)}, {}^{13}\\mathrm{C NMR (125 MHz, CDCl_3)}. \\text{Derivatives: per-MTPA esters } ({}^{1}\\mathrm{H NMR}). \\text{Biological activities } (\\mu g/mL): \\text{BST } LC_{50}\\ 1.3\\times10^{-1}, \\text{A-549 } ED_{50}\\ 2.8\\times10^{-6}, \\text{MCF-7 } ED_{50}\\ 4.2\\times10^{-6}, \\text{HT-29 } ED_{50}\\ 5.7\\times10^{-6}, \\text{A-498 } ED_{50}\\ 1.0, \\text{PC-3 } ED_{50}\\ 1.1, \\text{PACA-2 } ED_{50}\\ 1.8. \\text{Source: } \\textit{Annona glabra}, \\text{leaves.}", "inline": true, "text_offset": 16, "text_span": 10, "bbox_estimated": true, "notation": "latex", "alt": "alpha sub D : minus 11.6 to the power of circ of c, 0.013, CHCl sub 3, UV of lambda sub max, MeOH, nm : 220 times log epsilon, 3.89, IR of nu sub max, film, cm to the power of minus 1 : 3330, 2919, 2850, 1747, 1717, 1469, 1320, 1203, 1064, 956, 758. MS: EIMS m over z 467, 449, 431, 413, 397, 379, 361, 327, 311, 309, 293, 291, 275, 241, 223, 205, 171, 141. NMR: to the power of 1 H NMR of 500 MHz, CDCl sub 3, to the power of 13 C NMR of 125 MHz, CDCl sub 3 . Derivatives: per minus MTPA esters of to the power of 1 H NMR . Biological activities of mu g over mL : BST LC sub 50 1.3 times 10 to the power of minus 1, A minus 549 ED sub 50 2.8 times 10 to the power of minus 6, MCF minus 7 ED sub 50 4.2 times 10 to the power of minus 6, HT minus 29 ED sub 50 5.7 times 10 to the power of minus 6, A minus 498 ED sub 50 1.0, PC minus 3 ED sub 50 1.1, PACA minus 2 ED sub 50 1.8. Source: textit Annona glabra, leaves.", "mathml": "[α]D:−11.6∘(c0.013,CHCl3),UV(λmax,MeOH,nm):220(logϵ3.89),IR(νmax,film,cm−1):3330,2919,2850,1747,1717,1469,1320,1203,1064,956,758.MS: EIMS m/z 467,449,431,413,397,379,361,327,311,309,293,291,275,241,223,205,171,141.NMR: 1HNMR(500MHz,CDCl3),13CNMR(125MHz,CDCl3).Derivatives: per-MTPA esters (1HNMR).Biological activities (μg/mL):BST LC50 1.3×10−1,A-549 ED50 2.8×10−6,MCF-7 ED50 4.2×10−6,HT-29 ED50 5.7×10−6,A-498 ED50 1.0,PC-3 ED50 1.1,PACA-2 ED50 1.8.Source: Annona glabra,leaves." } }, { "id": "p27.17.2", "order": 139, "type": "formula", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "\\text{White wax solid. } [\\alpha]_D: -11.6^\\circ (c\\,0.013, \\text{CHCl}_3). \\text{UV } (\\lambda_{max}, \\text{MeOH, nm}): 220 (\\log \\epsilon\\,3.89). \\text{IR } (\\nu_{max}, \\text{film, cm}^{-1}): 3330, 2919, 2850, 1747, 1717, 1469, 1320, 1203, 1064, 956, 758. \\text{MS: EIMS } m/z\\,467, 449, 431, 413, 397, 379, 361, 327, 311, 309, 293, 291, 275, 241, 223, 205, 171, 141. \\text{NMR: }{}^1\\text{H NMR (500 MHz, CDCl}_3), {}^{13}\\text{C NMR (125 MHz, CDCl}_3). \\text{Derivatives: per-MTPA esters } ({}^1\\text{H NMR}). \\text{Biological activities } (\\mu\\text{g/mL}): \\text{BST LC}_{50}\\,1.3\\times10^{-1}, \\text{A-549 ED}_{50}\\,2.8\\times10^{-6}, \\text{MCF-7 ED}_{50}\\,4.2\\times10^{-6}, \\text{HT-29 ED}_{50}\\,5.7\\times10^{-6}, \\text{A-498 ED}_{50}\\,1.0, \\text{PC-3 ED}_{50}\\,1.1, \\text{PACA-2 ED}_{50}\\,1.8. \\text{Source: } \\textit{Annona glabra}, \\text{leaves.}", "attrs": { "latex": "\\text{White wax solid. } [\\alpha]_D: -11.6^\\circ (c\\,0.013, \\text{CHCl}_3). \\text{UV } (\\lambda_{max}, \\text{MeOH, nm}): 220 (\\log \\epsilon\\,3.89). \\text{IR } (\\nu_{max}, \\text{film, cm}^{-1}): 3330, 2919, 2850, 1747, 1717, 1469, 1320, 1203, 1064, 956, 758. \\text{MS: EIMS } m/z\\,467, 449, 431, 413, 397, 379, 361, 327, 311, 309, 293, 291, 275, 241, 223, 205, 171, 141. \\text{NMR: }{}^1\\text{H NMR (500 MHz, CDCl}_3), {}^{13}\\text{C NMR (125 MHz, CDCl}_3). \\text{Derivatives: per-MTPA esters } ({}^1\\text{H NMR}). \\text{Biological activities } (\\mu\\text{g/mL}): \\text{BST LC}_{50}\\,1.3\\times10^{-1}, \\text{A-549 ED}_{50}\\,2.8\\times10^{-6}, \\text{MCF-7 ED}_{50}\\,4.2\\times10^{-6}, \\text{HT-29 ED}_{50}\\,5.7\\times10^{-6}, \\text{A-498 ED}_{50}\\,1.0, \\text{PC-3 ED}_{50}\\,1.1, \\text{PACA-2 ED}_{50}\\,1.8. \\text{Source: } \\textit{Annona glabra}, \\text{leaves.}", "inline": true, "text_offset": 56, "text_span": 10, "bbox_estimated": true, "notation": "latex", "alt": "White wax solid. alpha sub D : minus 11.6 to the power of circ of c, 0.013, CHCl sub 3 . UV of lambda sub max, MeOH, nm : 220 times log epsilon, 3.89 . IR of nu sub max, film, cm to the power of minus 1 : 3330, 2919, 2850, 1747, 1717, 1469, 1320, 1203, 1064, 956, 758. MS: EIMS m over z, 467, 449, 431, 413, 397, 379, 361, 327, 311, 309, 293, 291, 275, 241, 223, 205, 171, 141. NMR: to the power of 1 H NMR of 500 MHz, CDCl sub 3, to the power of 13 C NMR of 125 MHz, CDCl sub 3 . Derivatives: per minus MTPA esters of to the power of 1 H NMR . Biological activities of mu g over mL : BST LC sub 50, 1.3 times 10 to the power of minus 1, A minus 549 ED sub 50, 2.8 times 10 to the power of minus 6, MCF minus 7 ED sub 50, 4.2 times 10 to the power of minus 6, HT minus 29 ED sub 50, 5.7 times 10 to the power of minus 6, A minus 498 ED sub 50, 1.0, PC minus 3 ED sub 50, 1.1, PACA minus 2 ED sub 50, 1.8. Source: textit Annona glabra, leaves.", "mathml": "White wax solid. [α]D:−11.6∘(c0.013,CHCl3).UV (λmax,MeOH, nm):220(logϵ3.89).IR (νmax,film, cm−1):3330,2919,2850,1747,1717,1469,1320,1203,1064,956,758.MS: EIMS m/z467,449,431,413,397,379,361,327,311,309,293,291,275,241,223,205,171,141.NMR: 1H NMR (500 MHz, CDCl3),13C NMR (125 MHz, CDCl3).Derivatives: per-MTPA esters (1H NMR).Biological activities (μg/mL):BST LC501.3×10−1,A-549 ED502.8×10−6,MCF-7 ED504.2×10−6,HT-29 ED505.7×10−6,A-498 ED501.0,PC-3 ED501.1,PACA-2 ED501.8.Source: Annona glabra,leaves." } }, { "id": "p27.17.3", "order": 140, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "ε", "attrs": { "inline": true, "text_offset": 87, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.17.4", "order": 141, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "\\nu_{max}", "attrs": { "inline": true, "text_offset": 109, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.17.5", "order": 142, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "⁻¹", "attrs": { "inline": true, "text_offset": 129, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.17.6", "order": 143, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "¹", "attrs": { "inline": true, "text_offset": 313, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.17.7", "order": 144, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "₃", "attrs": { "inline": true, "text_offset": 342, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.17.8", "order": 145, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "¹³", "attrs": { "inline": true, "text_offset": 355, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.17.9", "order": 146, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "₃", "attrs": { "inline": true, "text_offset": 384, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.17.10", "order": 147, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "¹", "attrs": { "inline": true, "text_offset": 428, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.11", "order": 148, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "μ", "attrs": { "inline": true, "text_offset": 471, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.12", "order": 149, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 495, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.13", "order": 150, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "×", "attrs": { "inline": true, "text_offset": 510, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.14", "order": 151, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "⁻¹", "attrs": { "inline": true, "text_offset": 524, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.15", "order": 152, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 545, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.16", "order": 153, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "×", "attrs": { "inline": true, "text_offset": 560, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.17", "order": 154, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "⁻⁶", "attrs": { "inline": true, "text_offset": 574, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.18", "order": 155, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 595, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.19", "order": 156, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "×", "attrs": { "inline": true, "text_offset": 610, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.20", "order": 157, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "⁻⁶", "attrs": { "inline": true, "text_offset": 624, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.21", "order": 158, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 645, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.22", "order": 159, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "×", "attrs": { "inline": true, "text_offset": 660, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.23", "order": 160, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "⁻⁶", "attrs": { "inline": true, "text_offset": 674, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.24", "order": 161, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 695, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.25", "order": 162, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 719, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.17.26", "order": 163, "type": "text", "bbox": { "l": 73.2, "t": 269.04, "r": 537.84, "b": 222 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 744, "text_span": 11, "bbox_estimated": true } } ] }, { "id": "p27.18", "order": 164, "type": "text", "bbox": { "l": 70.32, "t": 219.84, "r": 219.12, "b": 208.8 }, "text": "94. glabracin B[p27.18.1] (C [p27.18.2]H [p27.18.3]O[p27.18.4], MW638)", "children": [ { "id": "p27.18.1", "order": 165, "type": "text", "bbox": { "l": 70.32, "t": 219.84, "r": 219.12, "b": 208.8 }, "text": "²⁴", "attrs": { "inline": true, "text_offset": 15, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.18.2", "order": 166, "type": "text", "bbox": { "l": 70.32, "t": 219.84, "r": 219.12, "b": 208.8 }, "text": "₃₇", "attrs": { "inline": true, "text_offset": 29, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.18.3", "order": 167, "type": "text", "bbox": { "l": 70.32, "t": 219.84, "r": 219.12, "b": 208.8 }, "text": "₆₈", "attrs": { "inline": true, "text_offset": 41, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.18.4", "order": 168, "type": "text", "bbox": { "l": 70.32, "t": 219.84, "r": 219.12, "b": 208.8 }, "text": "₇", "attrs": { "inline": true, "text_offset": 52, "text_span": 10, "bbox_estimated": true } } ] }, { "id": "p27.19", "order": 169, "type": "formula", "bbox": { "l": 153.12, "t": 202.8, "r": 457.2, "b": 104.88 }, "text": "", "attrs": { "block_label": "image", "alt": "Skeletal structure of an annonaceous acetogenin: bis-tetrahydrofuran butenolide with threo diol and hydroxyl groups, with NM…", "source": "vision" } }, { "id": "p27.20", "order": 170, "type": "table", "bbox": { "l": 154.32, "t": 142.8, "r": 429.84, "b": 107.04 }, "text": "", "attrs": { "block_label": "table", "n_rows": 3, "n_cols": 8, "integrity": { "skipped": "no_text_layer" } }, "children": [ { "id": "p27.20.1", "order": 171, "type": "table_cell", "bbox": { "l": 154.32, "t": 142.8, "r": 188.76, "b": 130.88 }, "text": "Position", "attrs": { "row": 0, "col": 0, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.20.2", "order": 172, "type": "table_cell", "bbox": { "l": 188.76, "t": 142.8, "r": 223.2, "b": 130.88 }, "text": "10", "attrs": { "row": 0, "col": 1, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.20.3", "order": 173, "type": "table_cell", "bbox": { "l": 223.2, "t": 142.8, "r": 257.64, "b": 130.88 }, "text": "11", "attrs": { "row": 0, "col": 2, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.20.4", "order": 174, "type": "table_cell", "bbox": { "l": 257.64, "t": 142.8, "r": 292.08, "b": 130.88 }, "text": "14", "attrs": { "row": 0, "col": 3, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.20.5", "order": 175, "type": "table_cell", "bbox": { "l": 292.08, "t": 142.8, "r": 326.52, "b": 130.88 }, "text": "15", "attrs": { "row": 0, "col": 4, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.20.6", "order": 176, "type": "table_cell", "bbox": { "l": 326.52, "t": 142.8, "r": 360.96, "b": 130.88 }, "text": "18", "attrs": { "row": 0, "col": 5, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.20.7", "order": 177, "type": "table_cell", "bbox": { "l": 360.96, "t": 142.8, "r": 395.4, "b": 130.88 }, "text": "23", "attrs": { "row": 0, "col": 6, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.20.8", "order": 178, "type": "table_cell", "bbox": { "l": 395.4, "t": 142.8, "r": 429.84, "b": 130.88 }, "text": "24", "attrs": { "row": 0, "col": 7, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p27.20.9", "order": 179, "type": "table_cell", "bbox": { "l": 154.32, "t": 130.88, "r": 188.76, "b": 118.96 }, "text": "¹H ( δ)", "attrs": { "row": 1, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p27.20.10", "order": 180, "type": "table_cell", "bbox": { "l": 188.76, "t": 130.88, "r": 223.2, "b": 118.96 }, "text": "3.42 m", "attrs": { "row": 1, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p27.20.11", "order": 181, "type": "table_cell", "bbox": { "l": 223.2, "t": 130.88, "r": 257.64, "b": 118.96 }, "text": "3.80 m", "attrs": { "row": 1, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p27.20.12", "order": 182, "type": "table_cell", "bbox": { "l": 257.64, "t": 130.88, "r": 292.08, "b": 118.96 }, "text": "3.80 m", "attrs": { "row": 1, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p27.20.13", "order": 183, "type": "table_cell", "bbox": { "l": 292.08, "t": 130.88, "r": 326.52, "b": 118.96 }, "text": "3.80 m", "attrs": { "row": 1, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p27.20.14", "order": 184, "type": "table_cell", "bbox": { "l": 326.52, "t": 130.88, "r": 360.96, "b": 118.96 }, "text": "3.80 m", "attrs": { "row": 1, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p27.20.15", "order": 185, "type": "table_cell", "bbox": { "l": 360.96, "t": 130.88, "r": 395.4, "b": 118.96 }, "text": "3.43 m", "attrs": { "row": 1, "col": 6, "rowspan": 1, "colspan": 1 } }, { "id": "p27.20.16", "order": 186, "type": "table_cell", "bbox": { "l": 395.4, "t": 130.88, "r": 429.84, "b": 118.96 }, "text": "3.43 m", "attrs": { "row": 1, "col": 7, "rowspan": 1, "colspan": 1 } }, { "id": "p27.20.17", "order": 187, "type": "table_cell", "bbox": { "l": 154.32, "t": 118.96, "r": 188.76, "b": 107.04 }, "text": "¹³C ( δ)", "attrs": { "row": 2, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p27.20.18", "order": 188, "type": "table_cell", "bbox": { "l": 188.76, "t": 118.96, "r": 223.2, "b": 107.04 }, "text": "74.18", "attrs": { "row": 2, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p27.20.19", "order": 189, "type": "table_cell", "bbox": { "l": 223.2, "t": 118.96, "r": 257.64, "b": 107.04 }, "text": "82.78", "attrs": { "row": 2, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p27.20.20", "order": 190, "type": "table_cell", "bbox": { "l": 257.64, "t": 118.96, "r": 292.08, "b": 107.04 }, "text": "82.60", "attrs": { "row": 2, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p27.20.21", "order": 191, "type": "table_cell", "bbox": { "l": 292.08, "t": 118.96, "r": 326.52, "b": 107.04 }, "text": "81.80", "attrs": { "row": 2, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p27.20.22", "order": 192, "type": "table_cell", "bbox": { "l": 326.52, "t": 118.96, "r": 360.96, "b": 107.04 }, "text": "79.31", "attrs": { "row": 2, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p27.20.23", "order": 193, "type": "table_cell", "bbox": { "l": 360.96, "t": 118.96, "r": 395.4, "b": 107.04 }, "text": "74.05", "attrs": { "row": 2, "col": 6, "rowspan": 1, "colspan": 1 } }, { "id": "p27.20.24", "order": 194, "type": "table_cell", "bbox": { "l": 395.4, "t": 118.96, "r": 429.84, "b": 107.04 }, "text": "74.35", "attrs": { "row": 2, "col": 7, "rowspan": 1, "colspan": 1 } } ] }, { "id": "p27.21", "order": 195, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "White waxy solid.[p27.21.1]: +16.9° (c Q05, CHCl_{3}). UV ([p27.21.2], MeOH, nm): 223 ([p27.21.3] 3.58). IR ([p27.21.4], film, cm^{-1}): 3382, 2926, 2854, 1748, 1540, 1456, 1318, 1270, 1199, 1072 MS: EIMS m/z 467, 449, 431, 413, 397, 379, 361, 327, 311, 309, 293, 291, 275, 241, 223, 205, 171, 141. NMR: [p27.21.5]H NMR (500 MHz, CDCl_{3}), [p27.21.6]C NMR (125 MHz, CDCl_{3}). Derivatives: per-MTPA esters ( [p27.21.7]H NMR). Biological activities ( [p27.21.8]g/mL): BST LC[p27.21.9] 3.1[p27.21.10] 10^{-1}, A-549 ED[p27.21.11] 1.6[p27.21.12] 10^{-1}, MCF-7 ED[p27.21.13] 1.8[p27.21.14] 10^{-3}, HT-29 ED[p27.21.15] 1.9[p27.21.16] 10^{-2}, A-498 ED[p27.21.17] 1.4, PC-3 ED[p27.21.18] 1.2, PACA-2 ED[p27.21.19] 2.8[p27.21.20] 10^{-1}. Source: Annona glabra. leaves.", "children": [ { "id": "p27.21.1", "order": 196, "type": "formula", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "\\text{White waxy solid.} \\; [\\alpha]_{D}: +16.9^{\\circ} (c\\,0.05, \\text{CHCl}_3). \\text{UV} (\\lambda_{\\max}, \\text{MeOH, nm}): 223 (\\log \\epsilon\\; 3.58). \\text{IR} (\\nu_{\\max}, \\text{film, cm}^{-1}): 3382, 2926, 2854, 1748, 1540, 1456, 1318, 1270, 1199, 1072. \\text{MS: EIMS } m/z\\ 467, 449, 431, 413, 397, 379, 361, 327, 311, 309, 293, 291, 275, 241, 223, 205, 171, 141. \\text{NMR: } {}^{1}\\text{H NMR (500 MHz, CDCl}_3), {}^{13}\\text{C NMR (125 MHz, CDCl}_3). \\text{Derivatives: per-MTPA esters } ({}^{1}\\text{H NMR}). \\text{Biological activities } (\\mu\\text{g/mL}): \\text{BST LC}_{50}\\ 3.1 \\times 10^{-1}, \\text{A-549 ED}_{50}\\ 1.6 \\times 10^{-1}, \\text{MCF-7 ED}_{50}\\ 1.8 \\times 10^{-3}, \\text{HT-29 ED}_{50}\\ 1.9 \\times 10^{-2}, \\text{A-498 ED}_{50}\\ 1.4, \\text{PC-3 ED}_{50}\\ 1.2, \\text{PACA-2 ED}_{50}\\ 2.8 \\times 10^{-1}. \\text{Source: } \\textit{Annona glabra}, \\text{leaves.}", "attrs": { "latex": "\\text{White waxy solid.} \\; [\\alpha]_{D}: +16.9^{\\circ} (c\\,0.05, \\text{CHCl}_3). \\text{UV} (\\lambda_{\\max}, \\text{MeOH, nm}): 223 (\\log \\epsilon\\; 3.58). \\text{IR} (\\nu_{\\max}, \\text{film, cm}^{-1}): 3382, 2926, 2854, 1748, 1540, 1456, 1318, 1270, 1199, 1072. \\text{MS: EIMS } m/z\\ 467, 449, 431, 413, 397, 379, 361, 327, 311, 309, 293, 291, 275, 241, 223, 205, 171, 141. \\text{NMR: } {}^{1}\\text{H NMR (500 MHz, CDCl}_3), {}^{13}\\text{C NMR (125 MHz, CDCl}_3). \\text{Derivatives: per-MTPA esters } ({}^{1}\\text{H NMR}). \\text{Biological activities } (\\mu\\text{g/mL}): \\text{BST LC}_{50}\\ 3.1 \\times 10^{-1}, \\text{A-549 ED}_{50}\\ 1.6 \\times 10^{-1}, \\text{MCF-7 ED}_{50}\\ 1.8 \\times 10^{-3}, \\text{HT-29 ED}_{50}\\ 1.9 \\times 10^{-2}, \\text{A-498 ED}_{50}\\ 1.4, \\text{PC-3 ED}_{50}\\ 1.2, \\text{PACA-2 ED}_{50}\\ 2.8 \\times 10^{-1}. \\text{Source: } \\textit{Annona glabra}, \\text{leaves.}", "inline": true, "text_offset": 17, "text_span": 10, "bbox_estimated": true, "notation": "latex", "alt": "White waxy solid. ; alpha sub D : plus 16.9 to the power of circ of c, 0.05, CHCl sub 3 . UV of lambda sub max, MeOH, nm : 223 times log epsilon ; 3.58 . IR of nu sub max, film, cm to the power of minus 1 : 3382, 2926, 2854, 1748, 1540, 1456, 1318, 1270, 1199, 1072. MS: EIMS m over z 467, 449, 431, 413, 397, 379, 361, 327, 311, 309, 293, 291, 275, 241, 223, 205, 171, 141. NMR: to the power of 1 H NMR of 500 MHz, CDCl sub 3, to the power of 13 C NMR of 125 MHz, CDCl sub 3 . Derivatives: per minus MTPA esters of to the power of 1 H NMR . Biological activities of mu g over mL : BST LC sub 50 3.1 times 10 to the power of minus 1, A minus 549 ED sub 50 1.6 times 10 to the power of minus 1, MCF minus 7 ED sub 50 1.8 times 10 to the power of minus 3, HT minus 29 ED sub 50 1.9 times 10 to the power of minus 2, A minus 498 ED sub 50 1.4, PC minus 3 ED sub 50 1.2, PACA minus 2 ED sub 50 2.8 times 10 to the power of minus 1 . Source: textit Annona glabra, leaves.", "mathml": "White waxy solid.[α]D:+16.9∘(c0.05,CHCl3).UV(λmax,MeOH, nm):223(logϵ3.58).IR(νmax,film, cm−1):3382,2926,2854,1748,1540,1456,1318,1270,1199,1072.MS: EIMS m/z 467,449,431,413,397,379,361,327,311,309,293,291,275,241,223,205,171,141.NMR: 1H NMR (500 MHz, CDCl3),13C NMR (125 MHz, CDCl3).Derivatives: per-MTPA esters (1H NMR).Biological activities (μg/mL):BST LC50 3.1×10−1,A-549 ED50 1.6×10−1,MCF-7 ED50 1.8×10−3,HT-29 ED50 1.9×10−2,A-498 ED50 1.4,PC-3 ED50 1.2,PACA-2 ED50 2.8×10−1.Source: Annona glabra,leaves." } }, { "id": "p27.21.2", "order": 197, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "\\lambda_{max}", "attrs": { "inline": true, "text_offset": 59, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.21.3", "order": 198, "type": "formula", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "\\text{White waxy solid. } [\\alpha]_D: +16.9^\\circ (c\\ 0.05, \\text{CHCl}_3). \\text{UV } (\\lambda_{\\max}, \\text{MeOH, nm}): 223 (\\log \\epsilon\\ 3.58). \\text{IR } (\\nu_{\\max}, \\text{film, cm}^{-1}): 3382, 2926, 2854, 1748, 1540, 1456, 1318, 1270, 1199, 1072. \\text{MS: EIMS } m/z\\ 467, 449, 431, 413, 397, 379, 361, 327, 311, 309, 293, 291, 275, 241, 223, 205, 171, 141. \\text{NMR: } {}^1\\text{H NMR (500 MHz, CDCl}_3), {}^{13}\\text{C NMR (125 MHz, CDCl}_3). \\text{Derivatives: per-MTPA esters (}^1\\text{H NMR). Biological activities } (\\mu\\text{g/mL}): \\text{BST LC}_{50}\\ 3.1 \\times 10^{-1}, \\text{A-549 ED}_{50}\\ 1.6 \\times 10^{-1}, \\text{MCF-7 ED}_{50}\\ 1.8 \\times 10^{-3}, \\text{HT-29 ED}_{50}\\ 1.9 \\times 10^{-2}, \\text{A-498 ED}_{50}\\ 1.4, \\text{PC-3 ED}_{50}\\ 1.2, \\text{PACA-2 ED}_{50}\\ 2.8 \\times 10^{-1}. \\text{Source: } \\textit{Annona glabra}, \\text{leaves}.", "attrs": { "latex": "\\text{White waxy solid. } [\\alpha]_D: +16.9^\\circ (c\\ 0.05, \\text{CHCl}_3). \\text{UV } (\\lambda_{\\max}, \\text{MeOH, nm}): 223 (\\log \\epsilon\\ 3.58). \\text{IR } (\\nu_{\\max}, \\text{film, cm}^{-1}): 3382, 2926, 2854, 1748, 1540, 1456, 1318, 1270, 1199, 1072. \\text{MS: EIMS } m/z\\ 467, 449, 431, 413, 397, 379, 361, 327, 311, 309, 293, 291, 275, 241, 223, 205, 171, 141. \\text{NMR: } {}^1\\text{H NMR (500 MHz, CDCl}_3), {}^{13}\\text{C NMR (125 MHz, CDCl}_3). \\text{Derivatives: per-MTPA esters (}^1\\text{H NMR). Biological activities } (\\mu\\text{g/mL}): \\text{BST LC}_{50}\\ 3.1 \\times 10^{-1}, \\text{A-549 ED}_{50}\\ 1.6 \\times 10^{-1}, \\text{MCF-7 ED}_{50}\\ 1.8 \\times 10^{-3}, \\text{HT-29 ED}_{50}\\ 1.9 \\times 10^{-2}, \\text{A-498 ED}_{50}\\ 1.4, \\text{PC-3 ED}_{50}\\ 1.2, \\text{PACA-2 ED}_{50}\\ 2.8 \\times 10^{-1}. \\text{Source: } \\textit{Annona glabra}, \\text{leaves}.", "inline": true, "text_offset": 87, "text_span": 10, "bbox_estimated": true, "notation": "latex", "alt": "White waxy solid. alpha sub D : plus 16.9 to the power of circ of c 0.05, CHCl sub 3 . UV of lambda sub max, MeOH, nm : 223 times log epsilon 3.58 . IR of nu sub max, film, cm to the power of minus 1 : 3382, 2926, 2854, 1748, 1540, 1456, 1318, 1270, 1199, 1072. MS: EIMS m over z 467, 449, 431, 413, 397, 379, 361, 327, 311, 309, 293, 291, 275, 241, 223, 205, 171, 141. NMR: to the power of 1 H NMR of 500 MHz, CDCl sub 3, to the power of 13 C NMR of 125 MHz, CDCl sub 3 . Derivatives: per minus MTPA esters of to the power of 1 H NMR . Biological activities of mu g over mL : BST LC sub 50 3.1 times 10 to the power of minus 1, A minus 549 ED sub 50 1.6 times 10 to the power of minus 1, MCF minus 7 ED sub 50 1.8 times 10 to the power of minus 3, HT minus 29 ED sub 50 1.9 times 10 to the power of minus 2, A minus 498 ED sub 50 1.4, PC minus 3 ED sub 50 1.2, PACA minus 2 ED sub 50 2.8 times 10 to the power of minus 1 . Source: textit Annona glabra, leaves .", "mathml": "White waxy solid. [α]D:+16.9∘(c 0.05,CHCl3).UV (λmax,MeOH, nm):223(logϵ 3.58).IR (νmax,film, cm−1):3382,2926,2854,1748,1540,1456,1318,1270,1199,1072.MS: EIMS m/z 467,449,431,413,397,379,361,327,311,309,293,291,275,241,223,205,171,141.NMR: 1H NMR (500 MHz, CDCl3),13C NMR (125 MHz, CDCl3).Derivatives: per-MTPA esters (1H NMR). Biological activities (μg/mL):BST LC50 3.1×10−1,A-549 ED50 1.6×10−1,MCF-7 ED50 1.8×10−3,HT-29 ED50 1.9×10−2,A-498 ED50 1.4,PC-3 ED50 1.2,PACA-2 ED50 2.8×10−1.Source: Annona glabra,leaves." } }, { "id": "p27.21.4", "order": 199, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "\\nu_{max}", "attrs": { "inline": true, "text_offset": 109, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.21.5", "order": 200, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "¹", "attrs": { "inline": true, "text_offset": 304, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.21.6", "order": 201, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "¹³", "attrs": { "inline": true, "text_offset": 341, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.21.7", "order": 202, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "¹", "attrs": { "inline": true, "text_offset": 409, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.21.8", "order": 203, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "μ", "attrs": { "inline": true, "text_offset": 451, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.21.9", "order": 204, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 474, "text_span": 10, "bbox_estimated": true } }, { "id": "p27.21.10", "order": 205, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "×", "attrs": { "inline": true, "text_offset": 488, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.21.11", "order": 206, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 517, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.21.12", "order": 207, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "×", "attrs": { "inline": true, "text_offset": 532, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.21.13", "order": 208, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 561, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.21.14", "order": 209, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "×", "attrs": { "inline": true, "text_offset": 576, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.21.15", "order": 210, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 605, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.21.16", "order": 211, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "×", "attrs": { "inline": true, "text_offset": 620, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.21.17", "order": 212, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 649, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.21.18", "order": 213, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 673, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.21.19", "order": 214, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "₅₀", "attrs": { "inline": true, "text_offset": 699, "text_span": 11, "bbox_estimated": true } }, { "id": "p27.21.20", "order": 215, "type": "text", "bbox": { "l": 71.52, "t": 101.52, "r": 540.96, "b": 54.72 }, "text": "×", "attrs": { "inline": true, "text_offset": 714, "text_span": 11, "bbox_estimated": true } } ] } ], "excluded_furniture": { "first": [], "last": [] } }