{ "document_id": 13701, "page": 18, "width_pt": 612, "height_pt": 792, "rotation": 0, "pipeline_version": "paddleocr-vl-1.6+paul-48", "engine": "paddleocr_vl", "source_run_id": 13812, "item_count": 188, "counts_by_type": { "footnote": 1, "formula": 22, "header": 4, "list": 1, "list_item": 2, "table": 4, "table_cell": 102, "text": 52 }, "build_ms": 24, "items": [ { "id": "p18.1", "order": 1, "type": "header", "bbox": { "l": 53.76, "t": 766.08, "r": 112.32, "b": 756.24 }, "text": "Invited Review", "attrs": { "block_label": "header" }, "level": 2 }, { "id": "p18.2", "order": 2, "type": "header", "bbox": { "l": 349.92, "t": 766.32, "r": 558, "b": 756 }, "text": "Journal of Natural Products, 1999, Vol. 62, No. 3 521", "attrs": { "block_label": "header" }, "level": 2 }, { "id": "p18.3", "order": 3, "type": "header", "bbox": { "l": 53.52, "t": 746.16, "r": 142.8, "b": 736.08 }, "text": "Table 4. (Continued)", "attrs": { "block_label": "figure_title" }, "level": 2 }, { "id": "p18.4", "order": 4, "type": "header", "bbox": { "l": 236.88, "t": 732, "r": 374.16, "b": 720.96 }, "text": "Mono-THF Acetogenins (Continued)", "attrs": { "block_label": "figure_title" }, "level": 2 }, { "id": "p18.5", "order": 5, "type": "text", "bbox": { "l": 56.64, "t": 719.28, "r": 211.68, "b": 708.24 }, "text": "45. annoglacin A [p18.5.1](C [p18.5.2]H [p18.5.3]O[p18.5.4], MW624)", "children": [ { "id": "p18.5.1", "order": 6, "type": "formula", "bbox": { "l": 56.64, "t": 719.28, "r": 211.68, "b": 708.24 }, "text": "²⁶", "attrs": { "latex": "^{26}", "inline": true, "text_offset": 17, "text_span": 9, "bbox_estimated": true, "alt": "to the power of 26", "mathml": "26" } }, { "id": "p18.5.2", "order": 7, "type": "text", "bbox": { "l": 56.64, "t": 719.28, "r": 211.68, "b": 708.24 }, "text": "₃₇", "attrs": { "inline": true, "text_offset": 29, "text_span": 9, "bbox_estimated": true } }, { "id": "p18.5.3", 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"order": 12, "type": "table_cell", "bbox": { "l": 155.28, "t": 655.68, "r": 189.16, "b": 643.84 }, "text": "Position", "attrs": { "row": 0, "col": 0, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.7.2", "order": 13, "type": "table_cell", "bbox": { "l": 189.16, "t": 655.68, "r": 223.04, "b": 643.84 }, "text": "12", "attrs": { "row": 0, "col": 1, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.7.3", "order": 14, "type": "table_cell", "bbox": { "l": 223.04, "t": 655.68, "r": 256.92, "b": 643.84 }, "text": "17", "attrs": { "row": 0, "col": 2, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.7.4", "order": 15, "type": "table_cell", "bbox": { "l": 256.92, "t": 655.68, "r": 290.8, "b": 643.84 }, "text": "18", "attrs": { "row": 0, "col": 3, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.7.5", 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"row": 2, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p18.7.15", "order": 26, "type": "table_cell", "bbox": { "l": 223.04, "t": 632, "r": 256.92, "b": 620.16 }, "text": "74.28", "attrs": { "row": 2, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p18.7.16", "order": 27, "type": "table_cell", "bbox": { "l": 256.92, "t": 632, "r": 290.8, "b": 620.16 }, "text": "83.18", "attrs": { "row": 2, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p18.7.17", "order": 28, "type": "table_cell", "bbox": { "l": 290.8, "t": 632, "r": 324.68, "b": 620.16 }, "text": "82.15", "attrs": { "row": 2, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p18.7.18", "order": 29, "type": "table_cell", "bbox": { "l": 324.68, "t": 632, "r": 358.56, "b": 620.16 }, "text": "71.54", "attrs": { "row": 2, "col": 5, "rowspan": 1, "colspan": 1 } } ] }, { "id": "p18.8", "order": 30, "type": "text", "bbox": { "l": 58.56, "t": 616.8, "r": 536.4, "b": 567.84 }, "text": "White waxy solid.[p18.8.1]: +15.0° (CHCl₃). UV ([p18.8.2], MeOH, nm): 21.5 (log[p18.8.3] 3.62). IR ([p18.8.4], film, cm[p18.8.5]): 3413, 2920, 2850, 2280, 1742, 1657, 1630, 1551, 1528, 1467, 1321, 1075, 850, 791. MS: EIMS m/z 425, 407, 355, 337, 319, 301, 269, 251, 233, 141. NMR: [p18.8.6]H NMR (500 MHz, CDCl[p18.8.7]), [p18.8.8]C NMR (125 MHz, CDCl[p18.8.9]). Derivatives: per-MTPA esters (1H NMR). Biological activities ( [p18.8.10]g/mL): BST LC[p18.8.11] 4.9[p18.8.12] 10[p18.8.13], A-549 ED[p18.8.14] 5.3[p18.8.15] 10[p18.8.16], MCF-7 ED[p18.8.17] 9.6[p18.8.18] 10[p18.8.19], HT-29 ED[p18.8.20] 5.3[p18.8.21] 10[p18.8.22], A-498 ED[p18.8.23] 9.0[p18.8.24] 10[p18.8.25], PC-3 ED[p18.8.26] 2.0[p18.8.27] 10[p18.8.28], PAC-2 ED[p18.8.29] 5.1[p18.8.30] 10[p18.8.31]. Source: Annona glabra, leaves.", "children": [ { "id": "p18.8.1", "order": 31, "type": "formula", "bbox": { "l": 58.56, "t": 616.8, "r": 536.4, "b": 567.84 }, "text": "[\\alpha]_{D}: +15.0^{\\circ} (\\text{CHCl}_3). \\text{UV} (\\lambda_{\\max}, \\text{MeOH}, \\text{nm}): 219 (\\log \\epsilon\\, 3.62). \\text{IR} (\\nu_{\\max}, \\text{film}, \\text{cm}^{-1}): 3413, 2920, 2850, 2280, 1742, 1657, 1630, 1551, 1528, 1467, 1321, 1075, 850, 791. \\text{MS: EIMS } m/z\\ 425, 407, 355, 337, 319, 301, 269, 251, 233, 141. \\text{NMR: } {}^{1}\\text{H NMR (500 MHz, CDCl}_3), {}^{13}\\text{C NMR (125 MHz, CDCl}_3). \\text{Derivatives: per-MTPA esters } ({}^{1}\\text{H NMR}). \\text{Biological activities } (\\mu\\text{g/mL}): \\text{BST LC}_{50}\\ 4.9 \\times 10^{-1}, \\text{A-549 ED}_{50}\\ 5.3 \\times 10^{-3}, \\text{MCF-7 ED}_{50}\\ 9.6 \\times 10^{-4}, \\text{HT-29 ED}_{50}\\ 5.3 \\times 10^{-3}, \\text{A-498 ED}_{50}\\ 9.0 \\times 10^{-1}, \\text{PC-3 ED}_{50}\\ 2.0 \\times 10^{-3}, \\text{PACA-2 ED}_{50}\\ 5.1 \\times 10^{-7}. \\text{Source: } \\textit{Annona glabra}, \\text{leaves.}", "attrs": { "latex": "[\\alpha]_{D}: +15.0^{\\circ} (\\text{CHCl}_3). \\text{UV} (\\lambda_{\\max}, \\text{MeOH}, \\text{nm}): 219 (\\log \\epsilon\\, 3.62). \\text{IR} (\\nu_{\\max}, \\text{film}, \\text{cm}^{-1}): 3413, 2920, 2850, 2280, 1742, 1657, 1630, 1551, 1528, 1467, 1321, 1075, 850, 791. \\text{MS: EIMS } m/z\\ 425, 407, 355, 337, 319, 301, 269, 251, 233, 141. \\text{NMR: } {}^{1}\\text{H NMR (500 MHz, CDCl}_3), {}^{13}\\text{C NMR (125 MHz, CDCl}_3). \\text{Derivatives: per-MTPA esters } ({}^{1}\\text{H NMR}). \\text{Biological activities } (\\mu\\text{g/mL}): \\text{BST LC}_{50}\\ 4.9 \\times 10^{-1}, \\text{A-549 ED}_{50}\\ 5.3 \\times 10^{-3}, \\text{MCF-7 ED}_{50}\\ 9.6 \\times 10^{-4}, \\text{HT-29 ED}_{50}\\ 5.3 \\times 10^{-3}, \\text{A-498 ED}_{50}\\ 9.0 \\times 10^{-1}, \\text{PC-3 ED}_{50}\\ 2.0 \\times 10^{-3}, \\text{PACA-2 ED}_{50}\\ 5.1 \\times 10^{-7}. \\text{Source: } \\textit{Annona glabra}, \\text{leaves.}", "inline": true, "text_offset": 17, "text_span": 9, "bbox_estimated": true, "notation": "latex", "alt": "alpha sub D : plus 15.0 to the power of circ of CHCl sub 3 . UV of lambda sub max, MeOH, nm : 219 times log epsilon, 3.62 . IR of nu sub max, film, cm to the power of minus 1 : 3413, 2920, 2850, 2280, 1742, 1657, 1630, 1551, 1528, 1467, 1321, 1075, 850, 791. MS: EIMS m over z 425, 407, 355, 337, 319, 301, 269, 251, 233, 141. NMR: to the power of 1 H NMR of 500 MHz, CDCl sub 3, to the power of 13 C NMR of 125 MHz, CDCl sub 3 . Derivatives: per minus MTPA esters of to the power of 1 H NMR . Biological activities of mu g over mL : BST LC sub 50 4.9 times 10 to the power of minus 1, A minus 549 ED sub 50 5.3 times 10 to the power of minus 3, MCF minus 7 ED sub 50 9.6 times 10 to the power of minus 4, HT minus 29 ED sub 50 5.3 times 10 to the power of minus 3, A minus 498 ED sub 50 9.0 times 10 to the power of minus 1, PC minus 3 ED sub 50 2.0 times 10 to the power of minus 3, PACA minus 2 ED sub 50 5.1 times 10 to the power of minus 7 . Source: textit Annona glabra, leaves.", "mathml": "[α]D:+15.0∘(CHCl3).UV(λmax,MeOH,nm):219(logϵ3.62).IR(νmax,film,cm−1):3413,2920,2850,2280,1742,1657,1630,1551,1528,1467,1321,1075,850,791.MS: EIMS m/z 425,407,355,337,319,301,269,251,233,141.NMR: 1H NMR (500 MHz, CDCl3),13C NMR (125 MHz, CDCl3).Derivatives: per-MTPA esters (1H NMR).Biological activities (μg/mL):BST LC50 4.9×10−1,A-549 ED50 5.3×10−3,MCF-7 ED50 9.6×10−4,HT-29 ED50 5.3×10−3,A-498 ED50 9.0×10−1,PC-3 ED50 2.0×10−3,PACA-2 ED50 5.1×10−7.Source: Annona glabra,leaves." } }, { "id": "p18.8.2", "order": 32, "type": "formula", "bbox": { "l": 58.56, "t": 616.8, "r": 536.4, "b": 567.84 }, "text": "\\lambda_{max}", "attrs": { "latex": "\\lambda_{max}", "inline": true, "text_offset": 48, "text_span": 9, "bbox_estimated": true, "notation": "latex", "alt": "lambda sub max", "mathml": "λmax" } }, { "id": "p18.8.3", "order": 33, "type": "text", "bbox": { "l": 58.56, "t": 616.8, "r": 536.4, "b": 567.84 }, "text": "ε", "attrs": { "inline": 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"type": "text", "bbox": { "l": 57.36, "t": 568.8, "r": 212.64, "b": 557.28 }, "text": "₃₇", "attrs": { "inline": true, "text_offset": 29, "text_span": 9, "bbox_estimated": true } }, { "id": "p18.9.3", "order": 65, "type": "text", "bbox": { "l": 57.36, "t": 568.8, "r": 212.64, "b": 557.28 }, "text": "₆₉", "attrs": { "inline": true, "text_offset": 40, "text_span": 9, "bbox_estimated": true } }, { "id": "p18.9.4", "order": 66, "type": "text", "bbox": { "l": 57.36, "t": 568.8, "r": 212.64, "b": 557.28 }, "text": "₇", "attrs": { "inline": true, "text_offset": 50, "text_span": 9, "bbox_estimated": true } } ] }, { "id": "p18.10", "order": 67, "type": "formula", "bbox": { "l": 151.92, "t": 551.52, "r": 457.44, "b": 459.36 }, "text": "", "attrs": { "block_label": "image", "alt": "Skeletal structure of an acetogenin-type annonaceous lactone with a butenolide, a bis-THF ring fragment and hydroxyls at C-4…", "source": "vision" } }, { "id": "p18.11", "order": 68, "type": "table", "bbox": { "l": 154.32, "t": 496.32, "r": 354.96, "b": 460.56 }, "text": "", "attrs": { "block_label": "table", "n_rows": 3, "n_cols": 6, "integrity": { "skipped": "no_text_layer" } }, "children": [ { "id": "p18.11.1", "order": 69, "type": "table_cell", "bbox": { "l": 154.32, "t": 496.32, "r": 187.76, "b": 484.4 }, "text": "Position", "attrs": { "row": 0, "col": 0, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.11.2", "order": 70, "type": "table_cell", "bbox": { "l": 187.76, "t": 496.32, "r": 221.2, "b": 484.4 }, "text": "12", "attrs": { "row": 0, "col": 1, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.11.3", "order": 71, "type": "table_cell", "bbox": { "l": 221.2, "t": 496.32, "r": 254.64, "b": 484.4 }, "text": "17", "attrs": { "row": 0, "col": 2, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.11.4", "order": 72, "type": "table_cell", "bbox": { "l": 254.64, "t": 496.32, "r": 288.08, "b": 484.4 }, "text": "18", "attrs": { "row": 0, "col": 3, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.11.5", "order": 73, "type": "table_cell", "bbox": { "l": 288.08, "t": 496.32, "r": 321.52, "b": 484.4 }, "text": "21", "attrs": { "row": 0, "col": 4, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.11.6", "order": 74, "type": "table_cell", "bbox": { "l": 321.52, "t": 496.32, "r": 354.96, "b": 484.4 }, "text": "22", "attrs": { "row": 0, "col": 5, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.11.7", "order": 75, "type": "table_cell", "bbox": { "l": 154.32, "t": 484.4, "r": 187.76, "b": 472.48 }, "text": "¹H ( \\delta )", "attrs": { "row": 1, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p18.11.8", "order": 76, "type": "table_cell", "bbox": { "l": 187.76, "t": 484.4, "r": 221.2, "b": 472.48 }, "text": "3.60 m", "attrs": { "row": 1, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p18.11.9", "order": 77, "type": "table_cell", "bbox": { "l": 221.2, "t": 484.4, "r": 254.64, "b": 472.48 }, "text": "3.41 m", "attrs": { "row": 1, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p18.11.10", "order": 78, "type": "table_cell", "bbox": { "l": 254.64, "t": 484.4, "r": 288.08, "b": 472.48 }, "text": "3.80 m", "attrs": { "row": 1, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p18.11.11", "order": 79, "type": "table_cell", "bbox": { "l": 288.08, "t": 484.4, "r": 321.52, "b": 472.48 }, "text": "3.80 m", "attrs": { "row": 1, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p18.11.12", "order": 80, "type": "table_cell", "bbox": { "l": 321.52, "t": 484.4, "r": 354.96, "b": 472.48 }, "text": "3.41 m", "attrs": { "row": 1, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p18.11.13", "order": 81, "type": "table_cell", "bbox": { "l": 154.32, "t": 472.48, "r": 187.76, "b": 460.56 }, "text": "¹³C ( \\delta )", "attrs": { "row": 2, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p18.11.14", "order": 82, "type": "table_cell", "bbox": { "l": 187.76, "t": 472.48, "r": 221.2, "b": 460.56 }, "text": "71.83", "attrs": { "row": 2, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p18.11.15", "order": 83, "type": "table_cell", "bbox": { "l": 221.2, "t": 472.48, "r": 254.64, "b": 460.56 }, "text": "74.00", "attrs": { "row": 2, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p18.11.16", "order": 84, "type": "table_cell", "bbox": { "l": 254.64, "t": 472.48, "r": 288.08, "b": 460.56 }, "text": "82.57", "attrs": { "row": 2, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p18.11.17", "order": 85, "type": "table_cell", "bbox": { "l": 288.08, "t": 472.48, "r": 321.52, "b": 460.56 }, "text": "82.64", "attrs": { "row": 2, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p18.11.18", "order": 86, "type": "table_cell", "bbox": { "l": 321.52, "t": 472.48, "r": 354.96, "b": 460.56 }, "text": "74.08", "attrs": { "row": 2, "col": 5, "rowspan": 1, "colspan": 1 } } ] }, { "id": "p18.12", "order": 87, "type": "text", "bbox": { "l": 59.04, "t": 457.68, "r": 553.68, "b": 409.68 }, "text": "White waxy solid.[p18.12.1]: +15.7° (CHCl_{3}). UV ([p18.12.2], MeOH, nm): 218 ([p18.12.3] 3.48). IR ([p18.12.4], film, cm^{-1}): 3453, 2920, 2851, 1735, 1548, 1530, 1512, 1462, 1409, 1318, 1275, 1106, 1075, 1022, 965, 855, 673. MS: EIMS m/z 425, 407, 355, 337, 319, 301, 269, 251, 233, 141. NMR: [p18.12.5]H NMR (500MHz, CDCl_{3}), [p18.12.6]C NMR (125MHz, CDCl_{3}). Derivatives: per-MTPA esters (^{1}H NMR). Biological activities ( [p18.12.7]g/mL): BST LC_{50} 1.7[p18.12.8] 10^{-1}, A-549 ED_{50} 2.8[p18.12.9] 10^{-3}, MCF-7 ED_{50} 6.2[p18.12.10] 10^{-4}, HT-29 ED_{50} 5.3[p18.12.11] 10^{-3}, A-498 ED_{50} 4.0[p18.12.12] 10^{-1}, PC-3 ED_{50} 8.4[p18.12.13] 10^{-4}, PACA-2 ED_{50} 1.2[p18.12.14] 10^{-6}. Source: Annona glabra, leaves.", "children": [ { "id": "p18.12.1", "order": 88, "type": "formula", "bbox": { "l": 59.04, "t": 457.68, "r": 553.68, "b": 409.68 }, "text": "[\\alpha]_{D}", "attrs": { "latex": "[\\alpha]_{D}", "inline": true, "text_offset": 17, "text_span": 10, "bbox_estimated": true, "notation": "latex", "alt": "alpha sub D", "mathml": "[α]D" } }, { "id": "p18.12.2", "order": 89, "type": "text", "bbox": { "l": 59.04, "t": 457.68, "r": 553.68, "b": 409.68 }, "text": "\\lambda_{max}", "attrs": { "inline": true, "text_offset": 52, "text_span": 10, "bbox_estimated": true } }, { "id": "p18.12.3", "order": 90, "type": "formula", "bbox": { "l": 59.04, "t": 457.68, "r": 553.68, "b": 409.68 }, "text": "\\log \\epsilon", "attrs": { "latex": "\\log \\epsilon", "inline": true, "text_offset": 80, "text_span": 10, "bbox_estimated": true, "notation": "latex", "alt": "log epsilon", "mathml": "logϵ" } }, { "id": "p18.12.4", "order": 91, "type": "formula", "bbox": { "l": 59.04, "t": 457.68, "r": 553.68, "b": 409.68 }, "text": "\\nu_{max}", "attrs": { "latex": "\\nu_{max}", "inline": true, "text_offset": 102, "text_span": 10, "bbox_estimated": true, "notation": "latex", "alt": "nu sub max", "mathml": "νmax" } }, { "id": "p18.12.5", "order": 92, "type": "text", "bbox": { "l": 59.04, "t": 457.68, "r": 553.68, "b": 409.68 }, "text": "¹", "attrs": { "inline": true, "text_offset": 297, "text_span": 10, "bbox_estimated": true } }, { "id": "p18.12.6", "order": 93, "type": "text", "bbox": { "l": 59.04, "t": 457.68, "r": 553.68, "b": 409.68 }, "text": "¹³", "attrs": { "inline": true, "text_offset": 333, "text_span": 10, "bbox_estimated": true } }, { "id": "p18.12.7", "order": 94, "type": "text", "bbox": { "l": 59.04, "t": 457.68, "r": 553.68, "b": 409.68 }, "text": "μ", "attrs": { "inline": true, "text_offset": 435, "text_span": 10, "bbox_estimated": true } }, { "id": "p18.12.8", "order": 95, "type": "text", "bbox": { "l": 59.04, "t": 457.68, "r": 553.68, "b": 409.68 }, "text": "×", "attrs": { "inline": true, "text_offset": 467, "text_span": 10, "bbox_estimated": true } }, { "id": "p18.12.9", "order": 96, "type": "text", "bbox": { "l": 59.04, "t": 457.68, "r": 553.68, "b": 409.68 }, "text": "×", "attrs": { "inline": true, "text_offset": 504, "text_span": 10, "bbox_estimated": true } }, { "id": "p18.12.10", "order": 97, "type": "text", "bbox": { "l": 59.04, "t": 457.68, "r": 553.68, "b": 409.68 }, "text": "×", "attrs": { "inline": true, "text_offset": 541, "text_span": 11, "bbox_estimated": true } }, { "id": "p18.12.11", "order": 98, "type": "text", "bbox": { "l": 59.04, "t": 457.68, "r": 553.68, "b": 409.68 }, "text": "×", "attrs": { "inline": true, "text_offset": 579, "text_span": 11, "bbox_estimated": true } }, { "id": "p18.12.12", "order": 99, "type": "text", "bbox": { "l": 59.04, "t": 457.68, "r": 553.68, "b": 409.68 }, "text": "×", "attrs": { "inline": true, "text_offset": 617, "text_span": 11, "bbox_estimated": true } }, { "id": "p18.12.13", "order": 100, "type": "text", "bbox": { "l": 59.04, "t": 457.68, "r": 553.68, "b": 409.68 }, "text": "×", "attrs": { "inline": true, "text_offset": 654, "text_span": 11, "bbox_estimated": true } }, { "id": "p18.12.14", "order": 101, "type": "text", "bbox": { "l": 59.04, "t": 457.68, "r": 553.68, "b": 409.68 }, "text": "×", "attrs": { "inline": true, "text_offset": 693, "text_span": 11, "bbox_estimated": true } } ] }, { "id": "p18.13", "order": 102, "type": "text", "bbox": { "l": 57.84, "t": 408.72, "r": 324.48, "b": 398.64 }, "text": "mosinone[p18.13.1] (reported as a cis and trans mixture) (C [p18.13.2]H [p18.13.3]O[p18.13.4], MW620)", "children": [ { "id": "p18.13.1", "order": 103, "type": "text", "bbox": { "l": 57.84, "t": 408.72, "r": 324.48, "b": 398.64 }, "text": "¹⁰⁵", "attrs": { "inline": true, "text_offset": 8, "text_span": 10, "bbox_estimated": true } }, { "id": "p18.13.2", "order": 104, "type": "formula", "bbox": { "l": 57.84, "t": 408.72, "r": 324.48, "b": 398.64 }, "text": "₃₇", "attrs": { "latex": "_{37}", "inline": true, "text_offset": 60, "text_span": 10, "bbox_estimated": true, "alt": "sub 37", "mathml": "37" } }, { "id": "p18.13.3", "order": 105, "type": "formula", "bbox": { "l": 57.84, "t": 408.72, "r": 324.48, "b": 398.64 }, "text": "₆₄", "attrs": { "latex": "_{64}", "inline": true, "text_offset": 72, "text_span": 10, "bbox_estimated": true, "alt": "sub 64", "mathml": "64" } }, { "id": "p18.13.4", "order": 106, "type": "text", "bbox": { "l": 57.84, "t": 408.72, "r": 324.48, "b": 398.64 }, "text": "₇", "attrs": { "inline": true, "text_offset": 83, "text_span": 10, "bbox_estimated": true } } ] }, { "id": "p18.14", "order": 107, "type": "formula", "bbox": { "l": 152.64, "t": 394.56, "r": 456.72, "b": 348.96 }, "text": "", "attrs": { "block_label": "image", "alt": "Skeletal structure of a polyketide-type macrolactone with a tetrahydrofuran ring, two hydroxyls, a ketone, a cis/trans alken…", "source": "vision" } }, { "id": "p18.15", "order": 108, "type": "list", "bbox": { "l": 57.12, "t": 343.44, "r": 160.08, "b": 281.04 }, "text": "", "attrs": { "item_count": 2 }, "children": [ { "id": "p18.15.1", "order": 109, "type": "list_item", "bbox": { "l": 57.36, "t": 343.44, "r": 149.04, "b": 333.36 }, "text": "(2,4-cis)-mosinone", "marker": "47.", "attrs": { "block_label": "paragraph_title" } }, { "id": "p18.15.2", "order": 110, "type": "list_item", "bbox": { "l": 57.12, "t": 291.12, "r": 160.08, "b": 281.04 }, "text": "(2,4-trans)-mosinone", "marker": "48." } ] }, { "id": "p18.16", "order": 111, "type": "table", "bbox": { "l": 169.68, "t": 332.4, "r": 441.6, "b": 241.68 }, "text": "", "attrs": { "block_label": "table", "n_rows": 6, "n_cols": 8, "integrity": { "skipped": "no_text_layer" } }, "children": [ { "id": "p18.16.1", "order": 112, "type": "table_cell", "bbox": { "l": 169.68, "t": 332.4, "r": 203.67, "b": 317.28 }, "text": "Position", "attrs": { "row": 0, "col": 0, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.16.2", "order": 113, "type": "table_cell", "bbox": { "l": 203.67, "t": 332.4, "r": 237.66, "b": 317.28 }, "text": "9", "attrs": { "row": 0, "col": 1, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.16.3", "order": 114, "type": "table_cell", "bbox": { "l": 237.66, "t": 332.4, "r": 271.65, "b": 317.28 }, "text": "15", "attrs": { "row": 0, "col": 2, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.16.4", "order": 115, "type": "table_cell", "bbox": { "l": 271.65, "t": 332.4, "r": 305.64, "b": 317.28 }, "text": "16", "attrs": { "row": 0, "col": 3, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.16.5", "order": 116, "type": "table_cell", "bbox": { "l": 305.64, "t": 332.4, "r": 339.63, "b": 317.28 }, "text": "19", "attrs": { "row": 0, "col": 4, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.16.6", "order": 117, "type": "table_cell", "bbox": { "l": 339.63, "t": 332.4, "r": 373.62, "b": 317.28 }, "text": "20", "attrs": { "row": 0, "col": 5, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.16.7", "order": 118, "type": "table_cell", "bbox": { "l": 373.62, "t": 332.4, "r": 407.61, "b": 317.28 }, "text": "23", "attrs": { "row": 0, "col": 6, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.16.8", "order": 119, "type": "table_cell", "bbox": { "l": 407.61, "t": 332.4, "r": 441.6, "b": 317.28 }, "text": "24", "attrs": { "row": 0, "col": 7, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.16.9", "order": 120, "type": "table_cell", "bbox": { "l": 169.68, "t": 317.28, "r": 203.67, "b": 302.16 }, "text": "¹H ( \\delta )", "attrs": { "row": 1, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.10", "order": 121, "type": "table_cell", "bbox": { "l": 203.67, "t": 317.28, "r": 237.66, "b": 302.16 }, "text": "--", "attrs": { "row": 1, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.11", "order": 122, "type": "table_cell", "bbox": { "l": 237.66, "t": 317.28, "r": 271.65, "b": 302.16 }, "text": "3.40 m", "attrs": { "row": 1, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.12", "order": 123, "type": "table_cell", "bbox": { "l": 271.65, "t": 317.28, "r": 305.64, "b": 302.16 }, "text": "3.80 m", "attrs": { "row": 1, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.13", "order": 124, "type": "table_cell", "bbox": { "l": 305.64, "t": 317.28, "r": 339.63, "b": 302.16 }, "text": "3.80 m", "attrs": { "row": 1, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.14", "order": 125, "type": "table_cell", "bbox": { "l": 339.63, "t": 317.28, "r": 373.62, "b": 302.16 }, "text": "3.41 m", "attrs": { "row": 1, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.15", "order": 126, "type": "table_cell", "bbox": { "l": 373.62, "t": 317.28, "r": 407.61, "b": 302.16 }, "text": "5.36 m", "attrs": { "row": 1, "col": 6, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.16", "order": 127, "type": "table_cell", "bbox": { "l": 407.61, "t": 317.28, "r": 441.6, "b": 302.16 }, "text": "5.39 m", "attrs": { "row": 1, "col": 7, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.17", "order": 128, "type": "table_cell", "bbox": { "l": 169.68, "t": 302.16, "r": 203.67, "b": 287.04 }, "text": "¹³C ( \\delta )", "attrs": { "row": 2, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.18", "order": 129, "type": "table_cell", "bbox": { "l": 203.67, "t": 302.16, "r": 237.66, "b": 287.04 }, "text": "210.80", "attrs": { "row": 2, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.19", "order": 130, "type": "table_cell", "bbox": { "l": 237.66, "t": 302.16, "r": 271.65, "b": 287.04 }, "text": "73.49", "attrs": { "row": 2, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.20", "order": 131, "type": "table_cell", "bbox": { "l": 271.65, "t": 302.16, "r": 305.64, "b": 287.04 }, "text": "82.63", "attrs": { "row": 2, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.21", "order": 132, "type": "table_cell", "bbox": { "l": 305.64, "t": 302.16, "r": 339.63, "b": 287.04 }, "text": "82.63", "attrs": { "row": 2, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.22", "order": 133, "type": "table_cell", "bbox": { "l": 339.63, "t": 302.16, "r": 373.62, "b": 287.04 }, "text": "73.91", "attrs": { "row": 2, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.23", "order": 134, "type": "table_cell", "bbox": { "l": 373.62, "t": 302.16, "r": 407.61, "b": 287.04 }, "text": "128.92", "attrs": { "row": 2, "col": 6, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.24", "order": 135, "type": "table_cell", "bbox": { "l": 407.61, "t": 302.16, "r": 441.6, "b": 287.04 }, "text": "130.78", "attrs": { "row": 2, "col": 7, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.25", "order": 136, "type": "table_cell", "bbox": { "l": 169.68, "t": 287.04, "r": 203.67, "b": 271.92 }, "text": "Position", "attrs": { "row": 3, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.26", "order": 137, "type": "table_cell", "bbox": { "l": 203.67, "t": 287.04, "r": 237.66, "b": 271.92 }, "text": "9", "attrs": { "row": 3, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.27", "order": 138, "type": "table_cell", "bbox": { "l": 237.66, "t": 287.04, "r": 271.65, "b": 271.92 }, "text": "15", "attrs": { "row": 3, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.28", "order": 139, "type": "table_cell", "bbox": { "l": 271.65, "t": 287.04, "r": 305.64, "b": 271.92 }, "text": "16", "attrs": { "row": 3, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.29", "order": 140, "type": "table_cell", "bbox": { "l": 305.64, "t": 287.04, "r": 339.63, "b": 271.92 }, "text": "19", "attrs": { "row": 3, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.30", "order": 141, "type": "table_cell", "bbox": { "l": 339.63, "t": 287.04, "r": 373.62, "b": 271.92 }, "text": "20", "attrs": { "row": 3, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.31", "order": 142, "type": "table_cell", "bbox": { "l": 373.62, "t": 287.04, "r": 407.61, "b": 271.92 }, "text": "23", "attrs": { "row": 3, "col": 6, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.32", "order": 143, "type": "table_cell", "bbox": { "l": 407.61, "t": 287.04, "r": 441.6, "b": 271.92 }, "text": "24", "attrs": { "row": 3, "col": 7, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.33", "order": 144, "type": "table_cell", "bbox": { "l": 169.68, "t": 271.92, "r": 203.67, "b": 256.8 }, "text": "¹H ( \\delta )", "attrs": { "row": 4, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.34", "order": 145, "type": "table_cell", "bbox": { "l": 203.67, "t": 271.92, "r": 237.66, "b": 256.8 }, "text": "--", "attrs": { "row": 4, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.35", "order": 146, "type": "table_cell", "bbox": { "l": 237.66, "t": 271.92, "r": 271.65, "b": 256.8 }, "text": "3.40 m", "attrs": { "row": 4, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.36", "order": 147, "type": "table_cell", "bbox": { "l": 271.65, "t": 271.92, "r": 305.64, "b": 256.8 }, "text": "3.80 m", "attrs": { "row": 4, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.37", "order": 148, "type": "table_cell", "bbox": { "l": 305.64, "t": 271.92, "r": 339.63, "b": 256.8 }, "text": "3.80 m", "attrs": { "row": 4, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.38", "order": 149, "type": "table_cell", "bbox": { "l": 339.63, "t": 271.92, "r": 373.62, "b": 256.8 }, "text": "3.41 m", "attrs": { "row": 4, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.39", "order": 150, "type": "table_cell", "bbox": { "l": 373.62, "t": 271.92, "r": 407.61, "b": 256.8 }, "text": "5.36 m", "attrs": { "row": 4, "col": 6, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.40", "order": 151, "type": "table_cell", "bbox": { "l": 407.61, "t": 271.92, "r": 441.6, "b": 256.8 }, "text": "5.39 m", "attrs": { "row": 4, "col": 7, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.41", "order": 152, "type": "table_cell", "bbox": { "l": 169.68, "t": 256.8, "r": 203.67, "b": 241.68 }, "text": "¹³C ( \\delta )", "attrs": { "row": 5, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.42", "order": 153, "type": "table_cell", "bbox": { "l": 203.67, "t": 256.8, "r": 237.66, "b": 241.68 }, "text": "210.80", "attrs": { "row": 5, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.43", "order": 154, "type": "table_cell", "bbox": { "l": 237.66, "t": 256.8, "r": 271.65, "b": 241.68 }, "text": "73.49", "attrs": { "row": 5, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.44", "order": 155, "type": "table_cell", "bbox": { "l": 271.65, "t": 256.8, "r": 305.64, "b": 241.68 }, "text": "82.63", "attrs": { "row": 5, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.45", "order": 156, "type": "table_cell", "bbox": { "l": 305.64, "t": 256.8, "r": 339.63, "b": 241.68 }, "text": "82.63", "attrs": { "row": 5, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.46", "order": 157, "type": "table_cell", "bbox": { "l": 339.63, "t": 256.8, "r": 373.62, "b": 241.68 }, "text": "73.91", "attrs": { "row": 5, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.47", "order": 158, "type": "table_cell", "bbox": { "l": 373.62, "t": 256.8, "r": 407.61, "b": 241.68 }, "text": "128.92", "attrs": { "row": 5, "col": 6, "rowspan": 1, "colspan": 1 } }, { "id": "p18.16.48", "order": 159, "type": "table_cell", "bbox": { "l": 407.61, "t": 256.8, "r": 441.6, "b": 241.68 }, "text": "130.78", "attrs": { "row": 5, "col": 7, "rowspan": 1, "colspan": 1 } } ] }, { "id": "p18.17", "order": 160, "type": "text", "bbox": { "l": 60.48, "t": 239.28, "r": 506.4, "b": 199.44 }, "text": "White waxy solid.[p18.17.1]: +4.8° (c 0.016, CH₂Cl₂). UV (λmax, MeOH, nm): 202 (log ε 2.96). MS: EIMS m/z 395, 377, 359, 323–307, 289, 225, 207. NMR: ¹H NMR (500 MHz, CDCl₃), ¹³C NMR (125 MHz, CDCl₃). Derivatives: per-MTPA esters (¹H NMR). Biological activities (μg/mL): BST LC₅₀ 4.4 × 10⁻¹, A-549 ED₅₀ > 1, MCF-7 ED₅₀ > 1, HT-29 ED₅₀ > 1, A-498 ED₅₀ > 1, PC-3 ED₅₀ 3.2 × 10⁻², PACA-2 ED₅₀ 2.2 × 10⁻¹. Source: Annona squamosa, stem bark.", "children": [ { "id": "p18.17.1", "order": 161, "type": "formula", "bbox": { "l": 60.48, "t": 239.28, "r": 506.4, "b": 199.44 }, "text": "[\\alpha]_{D}", "attrs": { "latex": "[\\alpha]_{D}", "inline": true, "text_offset": 17, "text_span": 10, "bbox_estimated": true, "notation": "latex", "alt": "alpha sub D", "mathml": "[α]D" } } ] }, { "id": "p18.18", "order": 162, "type": "text", "bbox": { "l": 57.36, "t": 199.92, "r": 198.48, "b": 189.36 }, "text": "49. mosin B[p18.18.1] (C [p18.18.2]H [p18.18.3]O[p18.18.4], MW594)", "children": [ { "id": "p18.18.1", "order": 163, "type": "formula", "bbox": { "l": 57.36, "t": 199.92, "r": 198.48, "b": 189.36 }, "text": "^{*105}", "attrs": { "latex": "^{*105}", "inline": true, "text_offset": 11, "text_span": 10, "bbox_estimated": true, "notation": "latex", "alt": "to the power of *105", "mathml": "*105" } }, { "id": "p18.18.2", "order": 164, "type": "formula", "bbox": { "l": 57.36, "t": 199.92, "r": 198.48, "b": 189.36 }, "text": "₃₅", "attrs": { "latex": "_{35}", "inline": true, "text_offset": 25, "text_span": 10, "bbox_estimated": true, "alt": "sub 35", "mathml": "35" } }, { "id": "p18.18.3", "order": 165, "type": "formula", "bbox": { "l": 57.36, "t": 199.92, "r": 198.48, "b": 189.36 }, "text": "₆₂", "attrs": { "latex": "_{62}", "inline": true, "text_offset": 37, "text_span": 10, "bbox_estimated": true, "alt": "sub 62", "mathml": "62" } }, { "id": "p18.18.4", "order": 166, "type": "text", "bbox": { "l": 57.36, "t": 199.92, "r": 198.48, "b": 189.36 }, "text": "₇", "attrs": { "inline": true, "text_offset": 48, "text_span": 10, "bbox_estimated": true } } ] }, { "id": "p18.19", "order": 167, "type": "formula", "bbox": { "l": 155.76, "t": 186.96, "r": 454.08, "b": 89.76 }, "text": "", "attrs": { "block_label": "image", "alt": "Skeletal structure of an annonaceous acetogenin: butenolide with a bis-THF core, C-9 ketone, C-4 hydroxyl and C-15/C-20 hydr…", "source": "vision" } }, { "id": "p18.20", "order": 168, "type": "table", "bbox": { "l": 157.2, "t": 128.64, "r": 359.04, "b": 91.92 }, "text": "", "attrs": { "block_label": "table", "n_rows": 3, "n_cols": 6, "integrity": { "skipped": "no_text_layer" } }, "children": [ { "id": "p18.20.1", "order": 169, "type": "table_cell", "bbox": { "l": 157.2, "t": 128.64, "r": 190.84, "b": 116.4 }, "text": "Position", "attrs": { "row": 0, "col": 0, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.20.2", "order": 170, "type": "table_cell", "bbox": { "l": 190.84, "t": 128.64, "r": 224.48, "b": 116.4 }, "text": "9", "attrs": { "row": 0, "col": 1, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.20.3", "order": 171, "type": "table_cell", "bbox": { "l": 224.48, "t": 128.64, "r": 258.12, "b": 116.4 }, "text": "15", "attrs": { "row": 0, "col": 2, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.20.4", "order": 172, "type": "table_cell", "bbox": { "l": 258.12, "t": 128.64, "r": 291.76, "b": 116.4 }, "text": "16", "attrs": { "row": 0, "col": 3, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.20.5", "order": 173, "type": "table_cell", "bbox": { "l": 291.76, "t": 128.64, "r": 325.4, "b": 116.4 }, "text": "19", "attrs": { "row": 0, "col": 4, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.20.6", "order": 174, "type": "table_cell", "bbox": { "l": 325.4, "t": 128.64, "r": 359.04, "b": 116.4 }, "text": "20", "attrs": { "row": 0, "col": 5, "rowspan": 1, "colspan": 1, "column_header": true, "header_source": "heuristic" } }, { "id": "p18.20.7", "order": 175, "type": "table_cell", "bbox": { "l": 157.2, "t": 116.4, "r": 190.84, "b": 104.16 }, "text": "¹H ( δ)", "attrs": { "row": 1, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p18.20.8", "order": 176, "type": "table_cell", "bbox": { "l": 190.84, "t": 116.4, "r": 224.48, "b": 104.16 }, "text": "--", "attrs": { "row": 1, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p18.20.9", "order": 177, "type": "table_cell", "bbox": { "l": 224.48, "t": 116.4, "r": 258.12, "b": 104.16 }, "text": "3.38 m", "attrs": { "row": 1, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p18.20.10", "order": 178, "type": "table_cell", "bbox": { "l": 258.12, "t": 116.4, "r": 291.76, "b": 104.16 }, "text": "3.81 m", "attrs": { "row": 1, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p18.20.11", "order": 179, "type": "table_cell", "bbox": { "l": 291.76, "t": 116.4, "r": 325.4, "b": 104.16 }, "text": "3.82 m", "attrs": { "row": 1, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p18.20.12", "order": 180, "type": "table_cell", "bbox": { "l": 325.4, "t": 116.4, "r": 359.04, "b": 104.16 }, "text": "3.87 m", "attrs": { "row": 1, "col": 5, "rowspan": 1, "colspan": 1 } }, { "id": "p18.20.13", "order": 181, "type": "table_cell", "bbox": { "l": 157.2, "t": 104.16, "r": 190.84, "b": 91.92 }, "text": "¹³C ( δ)", "attrs": { "row": 2, "col": 0, "rowspan": 1, "colspan": 1 } }, { "id": "p18.20.14", "order": 182, "type": "table_cell", "bbox": { "l": 190.84, "t": 104.16, "r": 224.48, "b": 91.92 }, "text": "211.38", "attrs": { "row": 2, "col": 1, "rowspan": 1, "colspan": 1 } }, { "id": "p18.20.15", "order": 183, "type": "table_cell", "bbox": { "l": 224.48, "t": 104.16, "r": 258.12, "b": 91.92 }, "text": "74.21", "attrs": { "row": 2, "col": 2, "rowspan": 1, "colspan": 1 } }, { "id": "p18.20.16", "order": 184, "type": "table_cell", "bbox": { "l": 258.12, "t": 104.16, "r": 291.76, "b": 91.92 }, "text": "83.18", "attrs": { "row": 2, "col": 3, "rowspan": 1, "colspan": 1 } }, { "id": "p18.20.17", "order": 185, "type": "table_cell", "bbox": { "l": 291.76, "t": 104.16, "r": 325.4, "b": 91.92 }, "text": "82.14", "attrs": { "row": 2, "col": 4, "rowspan": 1, "colspan": 1 } }, { "id": "p18.20.18", "order": 186, "type": "table_cell", "bbox": { "l": 325.4, "t": 104.16, "r": 359.04, "b": 91.92 }, "text": "71.51", "attrs": { "row": 2, "col": 5, "rowspan": 1, "colspan": 1 } } ] }, { "id": "p18.21", "order": 187, "type": "footnote", "bbox": { "l": 59.28, "t": 88.08, "r": 497.52, "b": 50.4 }, "text": "White waxy solid.[p18.21.1]: +11.5° (c 0.005, CH₂Cl₂). UV (λmax, MeOH, nm): 222 (log ε 3.57). MS: EIMS m/z 325, 307, 289, 225, 207. NMR: ¹H NMR (500MHz, CDCl₃), ¹³C NMR (125MHz, CDCl₃). Derivatives: per-MTPA esters (¹H NMR). Biological activities (μg/mL): BST LC₅₀ 2.9 × 10⁻¹, A-549 ED₅₀ 9.4 × 10⁻¹, MCF-7 ED₅₀ > 1, HT-29 ED₅₀ > 1, A-498 ED₅₀ > 1 × 10⁻¹, PC-3 ED₅₀ > 1, PACA-2 ED₅₀ 1.2 × 10⁻⁴. Source: Annona squamosa, stem bark.", "attrs": { "block_label": "vision_footnote" }, "children": [ { "id": "p18.21.1", "order": 188, "type": "text", "bbox": { "l": 59.28, "t": 88.08, "r": 497.52, "b": 50.4 }, "text": "[\\alpha]_{D}", "attrs": { "inline": true, "text_offset": 17, "text_span": 10, "bbox_estimated": true } } ] } ], "excluded_furniture": { "first": [], "last": [] } }