{
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    "source_run_id": 11603,
    "item_count": 9,
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            "id": "p2.1",
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            "text": "Dissected brain tissue must include a complete cross section of the brain stem and either cerebellum or hippocampus. All material submitted with a sample, including the carcass, should be held frozen until the test is completed and results reported. A single additional freeze-thaw cycle will have no effect on rabies-specific staining if repeat testing of the sample should be required, and the freeze-thaw cycle may eliminate or reduce some non-specific staining. Retention of the carcass is necessary to verify the identity of an animal in the case of unusual test results, and to identify a wild animal to species. Sample identifiers (accession numbers) should be used to label boxes and all items accompanying the sample. All necropsy and tissue processing must include proper identification of each sample and avoidance of any practice that could lead to cross contamination of samples. Each specimen should be handled on a clean work surface with new disposable gloves. All instruments used during necropsy, dissection, and slide preparation must be thoroughly disinfected by boiling or autoclaving followed by thorough washing before reuse. Instruments not in use should be kept in closed storage. Only those instruments in use for processing a single sample should be exposed. Frozen reference material taken at necropsy should be retained in the laboratory for all test samples. Most laboratories maintain test samples for 2 to 6 months, but representative positive samples should be maintained for longer periods for use as controls, for epidemiologic typing, and for other purposes. Storage containers for reference material must be large enough that reserved portions of brain stem and cerebellum (and hippocampus, if desired) remain as recognizably separate pieces and allow complete cross sections to be made if repeat testing is required. A video describing necropsy procedures is available from the CDC."
        },
        {
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            "type": "heading",
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            "text": "V. Preparation of Impression Slides / Smears",
            "attrs": {
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        {
            "id": "p2.3",
            "order": 3,
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            "text": "A. Sampling. While a positive finding of rabies virus antigen in any tissue is diagnostic of rabies infection, a negative finding for rabies can be made only if the diagnostic test includes examination of at least two areas of the brain: brain stem and preferably cerebellum (Figures 2,3,4,5,6,7,8,9,10,11,12,13). A complete cross section of the brain stem is required. If brain stem is unavailable and other brain tissues are negative, the sample must be considered unsatisfactory for testing. If cerebellum is unavailable, a diagnosis may be made by examination of brain stem and hippocampus (Figures 14 and 15). Each brain area is tested"
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        {
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            "type": "figure",
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            "text": "",
            "attrs": {
                "block_label": "image"
            }
        },
        {
            "id": "p2.5",
            "order": 5,
            "type": "caption",
            "bbox": {
                "l": 311.28,
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            "text": "Figure 2. Dorsal view of brain",
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        },
        {
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            "type": "figure",
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            "text": "",
            "attrs": {
                "block_label": "image",
                "embedded_text": "Hindbrain Midbrain\nMedulla Pons\nBrainstem"
            }
        },
        {
            "id": "p2.7",
            "order": 7,
            "type": "caption",
            "bbox": {
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            "text": "Figure 3. Ventral view of brain showing areas of brain stem suitable for rabies testing",
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            "type": "figure",
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            "text": "",
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        },
        {
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            "text": "Figure 4. Lateral view of brain with cerebrum removed to show the extension of brain stem beneath the cerebellum. A rabies diagnosis should include an observation of the cut surface of a cross section of the brain stem (through the medulla, pons, or midbrain area) and the cerebellum (through each hemisphere and the vermis). For example, a cross section of the midbrain area (dashed line) would include all tissues necessary for rabies diagnosis",
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